Navigation Links
Breakthrough in spinal injury treatment
Date:9/19/2008

Manipulating embryo-derived stem cells before transplanting them may hold the key to optimizing stem cell technologies for repairing spinal cord injuries in humans. Research published in BioMed Central's open access Journal of Biology, may lead to cell based therapies for victims of paralysis to recover the use of their bodies without the risk of transplant induced pain syndromes.

Dr. Stephen Davies, Associate Professor of Neurosurgery at the University of Colorado Denver School of Medicine, reported that in collaboration with researchers at the University of Rochester, NY his research team has transplanted two types of the major support cells of the brain and spinal cord, cells called astrocytes. These two types of astrocytes, which are both made from the same embryo-derived stem cell-like precursor cell, have remarkably different effects on the spinal repair process.

Using signal molecules known to be involved in the generation of embryonic astrocytes during spinal cord development, the researchers were able to make pure cultures of two different types of astrocytes from the GRP cells.

When Dr. Davies and his team transplanted these two types of astrocytes into the injured spinal cord, they had dramatically different effects. One type of astrocyte called GDAsBMP was remarkably effective at promoting nerve regeneration and recovery of limb motion when transplanted into spinal cord injuries. However, the other type of astrocyte cell generated called GDAsCNTF, not only failed to promote nerve fiber regeneration or functional recovery but also caused neuropathic pain, a severe side effect that was not seen in rats treated with GDAsBMP.

"To our knowledge, this is the first time that two distinct sub-types of astrocyte support cells generated from a common stem cell-like precursor cell have been shown to have robustly different effects when transplanted into the injured adult nervous system," co-author Dr. Mayer-Prosch
'/>"/>

Contact: Graeme Baldwin
graeme.baldwin@biomedcentral.com
44-079-205-86437
BioMed Central
Source:Eurekalert

Page: 1 2

Related biology technology :

1. Sigma-Aldrich Launches Breakthrough Genome-Editing Tools
2. Stoppert Named as President and CEO at Breakthrough Renewable Technology Firm Segetis, Inc
3. iZumi Bio, Inc. Recruits Leading iPS Scientist, John Dimos, to Translate Stem Cell Breakthrough Into Patient Benefits
4. Breakthrough Technology Makes High Octane Fuel Obsolete
5. Pharmaceutical Institute, in Collaboration With Campbell Alliance, Releases Second Edition of Breakthrough Book on the Inner Workings of the Pharmaceutical Industry
6. BioElectronics ActiPatch(TM) Product Chosen as One of 9 Medical Breakthroughs That May Change Your Life
7. Quantum computing breakthrough arises from unknown molecule
8. Breakthrough Slashes $7 Corn Over Half for Cattle Feeders
9. Breakthroughs Ahead, Endocrine Society Tells Security Analysts
10. BioNeutral Announces a BREAKTHROUGH in the Fight Against Bioterrorism
11. NC State breakthrough results in super-hard nanocrystalline iron that can take the heat
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/19/2014)... , September 19, 2014 , ... European Society for Paediatric Endocrinology (ESPE) Meeting  ... and medical research in the field of growth  , ... Darmstadt, Germany , today announced the ... for 2014. The awards were announced during a Satellite ...
(Date:9/18/2014)... -- About POCT POCT, also ... laboratory. It helps in making fast clinical decisions, ... POCT is gaining popularity due to the increasing ... diabetes, heart disease, and obesity. It is generally ... minimize errors during the diagnosis of patients. POCT ...
(Date:9/18/2014)... DUBLIN, Ireland , September 18, ... ,Research and Markets ( http://www.researchandmarkets.com/research/czvg3s/biocompatible ) ... "Biocompatible Materials - Global Strategic ... offering. ,     (Logo: http://photos.prnewswire.com/prnh/20130307/600769) ,This report ... Materials in US$ Million by the ...
(Date:9/18/2014)... , Sept. 18, 2014 Research ... the "Global N-acetylcysteine Industry Report 2014" ... Global N-acetylcysteine Industry Report 2014 is a professional ... the global N-acetylcysteine industry. The report ... definitions, classifications, applications and industry chain structure. The ...
Breaking Biology Technology:EMD Serono Awards Grant for Growth Innovation (GGI) for the First Time 2EMD Serono Awards Grant for Growth Innovation (GGI) for the First Time 3POCT Market in China 2014-2018 2Biocompatible Materials - Global Strategic Business Report 2014 2Biocompatible Materials - Global Strategic Business Report 2014 3Global N-acetylcysteine Industry Report 2014 2
... Johnson Controls , responding to increasing global demand ... a new business division to develop and service alternative ... unit will focus on geothermal, solar, biomass, wind, and ... Controls expects increased demand for these alternative forms of ...
... RedPrairie Corp. has signed a definitive agreement ... software based in Quebec City, Canada. , ,Terms of ... expected to close by the end of February. ... combined companies will operate under the RedPrairie name, and ...
... rather see - a shrinkage of one percent in the global ... question posed in Madison during a briefing on global climate change, ... cost of taking action to stabilize greenhouse gas emissions ... usual, according to British economist Lorraine Hamid. , ,The briefing was ...
Cached Biology Technology:Economist calls for an end to "business as usual" on climate change 2Economist calls for an end to "business as usual" on climate change 3
(Date:9/18/2014)... a world-leading provider of scientific, technical and medical ... Management Society (ARMS), recognized the academic research achievements ... Young Researcher of the Year Awards. , The ... Convention Centre and in conjunction with the ARMS ... Australia,s and New Zealand,s scientific community. Guest of ...
(Date:9/18/2014)... clownfish larvae can swim up to 400 kilometres in search ... with environmental change. , Clownfish spend their entire adult lives ... they must wander the open ocean, says study co-author, Dr ... Reef Studies (Coral CoE) at James Cook University. , "In ... we,ve been given a rare glimpse into how far they ...
(Date:9/17/2014)... Arts and Humanities has received a $260,000 grant from ... "The Boundaries of the Human in the Age of ... wide-ranging series of events aimed at exploring two compelling ... and researchers who are exploring the boundaries of our ... and the other involves the increasingly influential hypothesis that ...
Breaking Biology News(10 mins):Elsevier and Australasian Research Management Society award scientists at Scopus ceremony 2Nemo's epic journey to find a new home 2Mellon Foundation awards grant for major project in the humanities and sciences 2
... the piano, first you have to learn notes, scales and chords ... of music. The same principle applies to speech and to reading, ... the rules of grammar. But how do separate small ... It has been shown that a specific area of the ...
... portable, wireless cameras and monitoring equipment for recording and ... who watches nature programs on TV. However, common to ... life, which becomes particularly troublesome when using such equipment ... the International Journal of Computational Science and Engineering ...
... that determine the size of plants have fascinated plant ... understood. An international research team led by plant scientists ... in the scientific journal The Plant Cell . ... from cell division to cell specialization. By extending the ...
Cached Biology News:How does the brain create sequences? 2A good tern deserves another 2Plant scientists unravel a molecular switch to stimulate leaf growth 2
... Varioskan is a high performance ... dispenser and incubator. With the advanced ... and reliability for drug discovery assay ... for fluorescence intensity, time-resolved fluorescence and ...
Strip Removal Tool 25/Box...
Oven mesh sheets, large, 23 x 23cm, pack of 5...
... Lambda Protein Phosphatase ... Mn2+-dependent protein phosphatase with ... threonine and tyrosine residues. ... amino-acid product of the ...
Biology Products: