Navigation Links
Breakthrough gene therapy prevents retinal degeneration
Date:8/16/2010

BOSTON (August 16, 2010) In one of only two studies of its kind, a study from researchers at Tufts University School of Medicine and the Sackler School of Graduate Biomedical Sciences at Tufts demonstrates that non-viral gene therapy can delay the onset of some forms of eye disease and preserve vision. The team developed nanoparticles to deliver therapeutic genes to the retina and found that treated mice temporarily retained more eyesight than controls. The study, published online in advance of print in Molecular Therapy, brings researchers closer to a non-viral gene therapy treatment for degenerative eye disorders.

"Our work shows that it is possible to attain therapeutic results using non-viral gene delivery methods, specifically, nanoparticles. Nanoparticles, which are small enough to penetrate cells and stable enough to protect DNA, are capable of preventing retinal cell death and preserving vision," said senior author Rajendra Kumar-Singh, PhD, associate professor of ophthalmology at Tufts University School of Medicine (TUSM) and member of the genetics; neuroscience; and cell, molecular, and developmental biology program faculties at the Sackler School of Graduate Biomedical Sciences at Tufts.

"The most common approach to gene therapy involves using a virus to deliver DNA to cells. While viruses are very efficient carriers, they can prompt immune responses that may lead to inflammation, cancer, or even death. Non-viral methods offer a safer alternative, but until now, efficiency has been a significant barrier," said Kumar-Singh.

In a model simulating the progression of human retinal degeneration, the researchers treated mice with nanoparticles carrying a gene for GDNF (Glial Cell Line-Derived Neurotrophic Factor), a protein known to protect the photoreceptor cells in the eye. Retinas treated with the GDNF-carrying nanoparticles showed significantly less photoreceptor cell death than controls. Preservation of these cel
'/>"/>

Contact: Siobhan Gallagher
617-636-6586
Tufts University, Health Sciences
Source:Eurekalert  

Page: 1 2

Related biology technology :

1. Stoppert Named as President and CEO at Breakthrough Renewable Technology Firm Segetis, Inc
2. Sigma-Aldrich Launches Breakthrough Genome-Editing Tools
3. Breakthrough in spinal injury treatment
4. Upcoming Energy Psychology Event - New Breakthrough Do It Yourself Healing
5. Upcoming Energy Psychology Event in Chapel Hill Will Provide Training in New Breakthrough Do It Yourself Healing
6. Pharma Opinions Site Reviews the Breakthrough Drugs of Pharmaceutical Companies
7. Breakthrough Technology Takes Egg Freezing from Myth to Dependable Reality
8. Singapore Medicine - Breakthrough Development of Cell Therapy Treatment for Cancer
9. Prominent Urologist Dr. David B. Samadi Presents Breakthrough Robotic Surgery Techniques on OR Live Webcast
10. Osteotechs Next Generation Grafting Material, MagniFuse(TM) Bone Graft, a Breakthrough in Bone Regeneration; MagniFuse(TM) Bone Graft seeks to redefine the standard of care in the U.S. bone graft substitute market estimated to be in excess of $1.2 billio
11. Michigan Company Founded upon What Could Be History's Most Important Breakthrough in AI and Robotics
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Breakthrough gene therapy prevents retinal degeneration
(Date:8/28/2014)... A new research platform uses a ... tiny structures undergoing stress and heating, an ... designs for microelectronics and batteries., This new ... about how heating and the surface stress ... Researchers have discussed the merits of surface-stress ...
(Date:8/28/2014)... The ability for organizations to attract top ... individuals to perform at the highest of levels, are ... to compete in this post–recession era. The pharmaceutical ... the sector increasingly focuses on the importance of employee-fit ... real results on the organization's development and the innovation ...
(Date:8/28/2014)... Kent, WA (PRWEB) August 28, 2014 ... Synder Filtration’s polymeric membranes to its stable of ... of available molecular weight cut-offs and include membrane filters ... a steady increase in customer demand for our membrane ... a greater variety of flat sheet membranes,” explains Sterlitech ...
(Date:8/28/2014)... USA (PRWEB) August 27, 2014 Scientists, ... month for SPIE Laser Damage 2014 symposium. ... materials for high-power lasers will run 14-17 September. The ... for optics and photonics . , The premier conference ... understanding laser damage to optical materials will engage researchers ...
Breaking Biology Technology:New analytical technology reveals 'nanomechanical' surface traits 2New analytical technology reveals 'nanomechanical' surface traits 3Klein Hersh International Leads Philadelphia Area Life Science Industry in Company Culture 2Klein Hersh International Leads Philadelphia Area Life Science Industry in Company Culture 3Sterlitech Corporation Enhances Its Selection of Flat Sheet Membrane Filters 2Laser Damage to Draw Researchers, Engineers, Scientists to 46th Annual Conference 2Laser Damage to Draw Researchers, Engineers, Scientists to 46th Annual Conference 3
... the diuretic hydrochlorothiazide (HCTZ) in ... in significant additional blood pressure reductions compared to either drug alone ... or more, medicines - single-tablet combinations simplify treatment by reducing ... number of pills patients take, EAST ...
... Named ,Illinois Rising Stars, CHICAGO, Jan. 18 ... property law firms in the United States, is,pleased to ... "Illinois,Super Lawyers" for 2008 in a survey conducted by ... designated "Rising Stars" in,Illinois., Meredith Martin Addy, chair ...
... Jan. 18 Abbott (NYSE: ABT ),announced today ... for its fully automated HTLV-I/HTLV-II blood screening test,for use ... for use by,laboratories to screen individual donations of blood ... Type I and/or human T --,lymphotropic virus Type II ...
Cached Biology Technology:Video and Photo: Tekturna HCT(R), a Single-tablet Combination of Tekturna(R)* and a Diuretic, Receives US Approval for Treatment of High Blood Pressure 2Video and Photo: Tekturna HCT(R), a Single-tablet Combination of Tekturna(R)* and a Diuretic, Receives US Approval for Treatment of High Blood Pressure 3Video and Photo: Tekturna HCT(R), a Single-tablet Combination of Tekturna(R)* and a Diuretic, Receives US Approval for Treatment of High Blood Pressure 4Video and Photo: Tekturna HCT(R), a Single-tablet Combination of Tekturna(R)* and a Diuretic, Receives US Approval for Treatment of High Blood Pressure 5Twenty-One Brinks Hofer Gilson & Lione Attorneys Named 2008 'Illinois Super Lawyers' 2Abbott Announces Approval of First Fully Automated Blood Screening Test for HTLV-I/HTLV-II 2Abbott Announces Approval of First Fully Automated Blood Screening Test for HTLV-I/HTLV-II 3
(Date:8/28/2014)... (August 28, 2014) Researchers at the University of ... muscular dystrophy (FSHD) to be used for muscle regeneration ... potential therapies for FSHD. , The research is published ... Reports . , There is no treatment for FSHD, ... common type of muscular dystrophy. FSHD is an unusual ...
(Date:8/28/2014)... , Aug. 28, 2014  Privacy Advocate and Senior ... Jennifer Lynch , joins the lineup of biometric and ... annual Biometrics UnPlugged Executive Summit in Tampa, ... Previously announced speakers include Steven Rahman, Director, Technology and ... Sector at Experian. The theme of this year,s event ...
(Date:8/28/2014)... and imaging how quickly blood flows in the brain ... abuse affects the brain, which may aid in improving ... treatment options for recovering drug addicts. The new method, ... University in New York, USA and the U.S. National ... Society,s (OSA) open-access journal Biomedical Optics Express ...
Breaking Biology News(10 mins):UMN researchers find animal model for understudied type of muscular dystrophy 2Biometrics UnPlugged Welcomes the Electronic Frontier Foundation's Jennifer Lynch to the Mobility at the Crossroads of Commerce and Privacy Summit 2This is your brain's blood vessels on drugs 2This is your brain's blood vessels on drugs 3
... palo verde, mesquite and acacia trees throughout the Southwestern U.S., ... of their offspring against the parasitic wasp species that attacks ... the seed beetles Mimosestes amicus , living all around ... but invisible to our eyes or nearly so. ...
... Carlos Mendes Santos (a.k.a. Louro) is a handyman in rural ... world with the highest biodiversity. Two years ago, he found ... of the off-the-grid house of amateur botanist and local plant ... be grown on a window sill for closer observation. In ...
... N.C. -- The number of sea turtles accidentally caught and ... declined by an estimated 90 percent since 1990, according to ... and Conservation International. The report, published in the scientific ... measures that have been put into place over the last ...
Cached Biology News:This beetle uses eggs as shields against wasps 2This beetle uses eggs as shields against wasps 3This beetle uses eggs as shields against wasps 4This beetle uses eggs as shields against wasps 5Amateur botanists in Brazil discover a genuflexing plant 2Amateur botanists in Brazil discover a genuflexing plant 3Accidental sea turtle deaths drop 90 percent in US fisheries 2Accidental sea turtle deaths drop 90 percent in US fisheries 3
Mixing speed from 750-3200RPM, small vortexing orbit of1.0mm...
Request Info...
Autoclavable, variable volumefitted w./ an anti-drip safety valve; borosilicate glass barrelprotected with transparentpolypropylene sleeve; spring-lock cursor design ensuresfine adjustment for exact ...
Spaced cover glasses to promote effective hybridization...
Biology Products: