Navigation Links
Breakthrough gene therapy prevents retinal degeneration
Date:8/16/2010

BOSTON (August 16, 2010) In one of only two studies of its kind, a study from researchers at Tufts University School of Medicine and the Sackler School of Graduate Biomedical Sciences at Tufts demonstrates that non-viral gene therapy can delay the onset of some forms of eye disease and preserve vision. The team developed nanoparticles to deliver therapeutic genes to the retina and found that treated mice temporarily retained more eyesight than controls. The study, published online in advance of print in Molecular Therapy, brings researchers closer to a non-viral gene therapy treatment for degenerative eye disorders.

"Our work shows that it is possible to attain therapeutic results using non-viral gene delivery methods, specifically, nanoparticles. Nanoparticles, which are small enough to penetrate cells and stable enough to protect DNA, are capable of preventing retinal cell death and preserving vision," said senior author Rajendra Kumar-Singh, PhD, associate professor of ophthalmology at Tufts University School of Medicine (TUSM) and member of the genetics; neuroscience; and cell, molecular, and developmental biology program faculties at the Sackler School of Graduate Biomedical Sciences at Tufts.

"The most common approach to gene therapy involves using a virus to deliver DNA to cells. While viruses are very efficient carriers, they can prompt immune responses that may lead to inflammation, cancer, or even death. Non-viral methods offer a safer alternative, but until now, efficiency has been a significant barrier," said Kumar-Singh.

In a model simulating the progression of human retinal degeneration, the researchers treated mice with nanoparticles carrying a gene for GDNF (Glial Cell Line-Derived Neurotrophic Factor), a protein known to protect the photoreceptor cells in the eye. Retinas treated with the GDNF-carrying nanoparticles showed significantly less photoreceptor cell death than controls. Preservation of these cel
'/>"/>

Contact: Siobhan Gallagher
617-636-6586
Tufts University, Health Sciences
Source:Eurekalert  

Page: 1 2

Related biology technology :

1. Stoppert Named as President and CEO at Breakthrough Renewable Technology Firm Segetis, Inc
2. Sigma-Aldrich Launches Breakthrough Genome-Editing Tools
3. Breakthrough in spinal injury treatment
4. Upcoming Energy Psychology Event - New Breakthrough Do It Yourself Healing
5. Upcoming Energy Psychology Event in Chapel Hill Will Provide Training in New Breakthrough Do It Yourself Healing
6. Pharma Opinions Site Reviews the Breakthrough Drugs of Pharmaceutical Companies
7. Breakthrough Technology Takes Egg Freezing from Myth to Dependable Reality
8. Singapore Medicine - Breakthrough Development of Cell Therapy Treatment for Cancer
9. Prominent Urologist Dr. David B. Samadi Presents Breakthrough Robotic Surgery Techniques on OR Live Webcast
10. Osteotechs Next Generation Grafting Material, MagniFuse(TM) Bone Graft, a Breakthrough in Bone Regeneration; MagniFuse(TM) Bone Graft seeks to redefine the standard of care in the U.S. bone graft substitute market estimated to be in excess of $1.2 billio
11. Michigan Company Founded upon What Could Be History's Most Important Breakthrough in AI and Robotics
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Breakthrough gene therapy prevents retinal degeneration
(Date:7/13/2014)... Dallas, TX (PRWEB) July 13, 2014 ... Silver Industry” is a professional and in-depth study on ... Global and China. , The report provides a basic ... chain structure. Global market analysis and Chinese domestic market ... trends and competitive landscape of the market. A comparison ...
(Date:7/11/2014)... BCC Research ( http://www.bccresearch.com ) reveals ... REACTION (PCR) TECHNOLOGY: GLOBAL MARKETS , the global market ... $140 billion in 2013. This is estimated to grow ... annual growth rate (CAGR) of 28.6%. , New digital ... exciting possibilities within the broader PCR field. The opportunities ...
(Date:7/10/2014)... 10, 2014 Women in the ... to an additional family planning option. Sayana® Press ... at all levels of the health system and ... a widely used contraceptive—Pfizer’s Depo-Provera® (depot medroxyprogesterone acetate)—with ... is the first of four African countries expected ...
(Date:7/10/2014)... July 10, 2014 Unraveling life’s mysteries ... The Archer Family purchased a DNA test ... but ended up with a lifetime of memories, sharing, ... the family members’ DNA genuinely brought the family closer ... search deeper into genetic history and prior to taking ...
Breaking Biology Technology:2014 Nano Silver Industry in Global and China Regions Development Proposals Analysis Available at DeepResearchReports.com 22014 Nano Silver Industry in Global and China Regions Development Proposals Analysis Available at DeepResearchReports.com 3Global Market for Digital Polymerase Chain Reaction Technology to Reach $490 Billion by 2018; Equipment Sector Accounts for the Fastest Growing Segment With 33% CAGR 2Global Market for Digital Polymerase Chain Reaction Technology to Reach $490 Billion by 2018; Equipment Sector Accounts for the Fastest Growing Segment With 33% CAGR 3Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 2Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 3Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 4Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 5Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 6Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 2Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 3Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 4Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 5
... YORK, Oct. 6, 2011 A new invention could ... is a portable, rapid pathogen screener that could ... in processing plants, before it is delivered to the ... as a single bacteria, and is approximately 50 times ...
... 6, 2011 ProteinSimple today announced the launch ... control monitoring of protein-based therapeutics. The iCE3 platform ... conference, October 9-13, 2011, at Amelia Island, FL. ... product purity closely. Imaged capillary electrophoresis (iCE) systems ...
... Luminex Corporation (NASDAQ: LMNX ) announced today that ... – Be The Match to raise awareness of the need ... match for the growing number of patients awaiting life-saving bone ... National Marrow Donor Registry in an effort to assist patients ...
Cached Biology Technology:Breakthrough in Preventing Food-borne Illnesses Wins $20,000 Grand Prize in Global Design Contest 2Breakthrough in Preventing Food-borne Illnesses Wins $20,000 Grand Prize in Global Design Contest 3Breakthrough in Preventing Food-borne Illnesses Wins $20,000 Grand Prize in Global Design Contest 4ProteinSimple Launches New System for Protein Biologics 2Luminex Corporation Joins Forces With the National Marrow Donor Program - Be The Match® 2Luminex Corporation Joins Forces With the National Marrow Donor Program - Be The Match® 3Luminex Corporation Joins Forces With the National Marrow Donor Program - Be The Match® 4
(Date:7/11/2014)... Research awarded Michael F. Holick, PhD, MD, of Boston ... V. Avioli Award. Holick, a professor of medicine, physiology ... the understanding of vitamin D and its role in ... of the American Society for Bone and Mineral Research ... research. It is named for ASBMR,s first president and ...
(Date:7/11/2014)... is available in German . ... method that uses the refraction of X-rays through a ... produced with this method are often of much higher ... the team of Prof. Franz Pfeiffer are particularly interested ... therapy including X-ray phase-contrast imaging. One main goal ...
(Date:7/11/2014)... researchers at the National Institute of Standards and ... their work more effectively, they often prove that ... was the case recently for M. Lorna De ... the growing specialization of glycomics. Glycomics is the ... glycans that are attached to proteins and lipids ...
Breaking Biology News(10 mins):BUSM's Michael F. Holick receives American Society for Bone and Mineral Research award 2New simple setup for X-ray phase contrast 2
... derivative, and was approved for the treatment of neuropathic ... 2002. However, little evidence is available on the effects ... attack period. A recent study by Yanbo Zhang and ... showed that excitatory amino acids and protein kinase C ...
... Ectobius is a major textbook example of an invasive ... region from northernmost Europe to southernmost Africa. Ectobius ... amber that is about 44 million years old, and its lineage ... a shocking new discovery has uprooted that view. In fact, it ...
... stink bugs as pests, especially as the brown marmorated stink ... beneficial, such as Podisus nigrispinus (Dallas), a predatory ... for various insect pests of cotton, soybean, tomato, corn, kale, ... Annals of the Entomological Society of America called ...
Cached Biology News:After a 49-million-year hiatus, a cockroach reappears in North America 2New study may aid rearing of stink bugs for biological control 2
BD BioCoat Collagen IV 35 mm Culture Dishes, tissue-culture treated polystyrene with a uniform application of mouse collagen type IV....
... are designed for sequencing inserts cloned into ... or T3 RNA polymerase promoters, or lambda ... at a concentration of 0.1 µg/µl in ... DNA sequencing reactions using SequiTherm™ EXCEL™ II ...
BD BioCoat Matrigel Matrix 35 mm Culture Dishes Coating : BD MatrigelTM Basement Membrane Matrix ,Surface : ECM/attachment factors ,Surface area : 9.6 cm2 ,Dim nominal : 35 mm x 10 mm ,Vo...
BD BioCoat Collagen I 35 mm Culture Dishes, tissue-culture treated polystyrene with a uniform application of rat tail collagen type I....
Biology Products: