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Breakthrough Technology Takes Egg Freezing from Myth to Dependable Reality
Date:10/24/2008

lect only chromosomally normal eggs for safe cryobanking are paradigm shifters. They give women a realistic fertility preservation alternative they can count on."

Normal Egg, Healthy Baby

In essence, ECT, focuses on a relatively new DNA test called Comparative Genomic Hybridization (CGH) to determine which eggs are chromosomally normal (euploid). It's well established that, barring other compromising medical factors or male infertility, it is euploid eggs that are most likely to yield chromosomally sound embryos, which in turn are the ones most likely to develop into healthy babies.

Indeed, ReproCure/SIRM investigators were able to illustrate that in the vast majority of cases, the transfer of one or two chromosomally normal (competent) embryos to a receptive uterine environment produced a baby almost 70% of the time.

The ECT process involves handpicking chromosomally normal eggs for preservation. Researchers now know that most eggs, even in young healthy women, are chromosomally abnormal (aneuploid). Further complicating things is the fact that the incidence of aneupolidy is random. One month a woman opting for egg freezing may be stimulated to produce 12 eggs and none will be normal. The next month, the same woman might produce six that are normal. The key to a successful outcome is freezing only the euploid eggs. In contrast to the scattershot approach of freezing every egg harvested - a minimum of 20 at most centers, ReproCure's technique requires that only four or five normal eggs be frozen and banked.

The CGH Factor

CGH is a delicate and complex test that screens the full complement of chromosomes in each egg. ReproCure/SIRM's dedicated team has an expertise and experience in egg/embryo CGH that is unmatched by any other center in the world, giving it an unbeatable track record in identifying chromosomally normal eggs. Only these are selected for vitrification (ultra-rapid freezing) and banking.

Once frozen, the
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SOURCE Sher Institutes for Reproductive Medicine
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