Navigation Links
Brain inflammation likely key initiator to prion and Parkinson's disease
Date:12/4/2012

Prion diseases represent a family of neurodegenerative disorders associated with the loss of brain cells and caused by proteins called prions (derived from 'protein' and 'infection'). The diseases are found in both humans and animals, such as Creutzfeld-Jakob disease and mad cow disease respectively. Although mostly harmless, prions can transform into infectious agents, which accumulate in the brain and destroy the nervous tissue.

But how exactly does the accumulation of prions cause destruction of the brain? "Understanding the process by which prions destroy neurons is critical for finding a cure for prion disease", says Isaac Crespo, first author of the publication. He and his colleagues tackled this question with a computational approach: They ran their own computer programmes on experimental data generated by other research groups, and identified a set of 16 proteins that seems to control the onset of the disease. Interestingly, almost all of these proteins have known functions in neuro-inflammation.

"What we consider remarkable and constitutes our main finding, is the key role that neuro-inflammation plays in initiating prion disease. This finding is not only relevant for prion diseases, but also for other 'protein misfolding diseases' such as Parkinson's and Alzheimer diseases" says Prof. Dr. Antonio del Sol, group leader of the Computational Biology group.

Since its publication on October 15th, Crespo's paper was accessed so frequently, that it received the mark 'Highly Accessed', only awarded to articles that are downloaded very frequently. The strong interest that scientists are showing for these research findings reflects the urgency with which researchers are trying to understand prion diseases for which there is no cure until today.


'/>"/>

Contact: Isaac Crespo
isaac.crespo@uni.lu
352-466-644-6197
University of Luxembourg
Source:Eurekalert

Page: 1

Related biology technology :

1. Precisely engineering 3-D brain tissues
2. Remixed brain waves reveal soundtrack of the human brain
3. First Effective Treatment For Traumatic Brain Injury Reported by Institute of Neurological Recovery, Even Years After Injury
4. A better brain implant: Slim electrode cozies up to single neurons
5. Human brains share a consistent genetic blueprint and possess enormous biochemical complexity
6. MRI Interventions and Brainlab Launch European Commercialization Effort with First ClearPoint Case in Europe
7. Blue Brain Project accurately predicts connections between neurons
8. $1 Million Global B.R.A.I.N. Prize Announced by Israel Brain Technologies
9. Conference Challenges Left-brain, Right-brain Dichotomy
10. First detailed timeline established for brains descent into Alzheimers
11. Beyond Batten Disease Foundation and American Brain Foundation Launch First Clinical Research Fellowship to Treat and Cure Juvenile Batten Disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/2/2016)... 2, 2016 Amgen (NASDAQ: AMGN ) ... the submission of a Marketing Authorization Application (MAA) to the ... to Avastin ® (bevacizumab). The companies believe this submission ... "The submission of ABP 215 to the ... our oncology portfolio," said Sean E. Harper , M.D., ...
(Date:12/2/2016)... ... December 01, 2016 , ... ... findings demonstrating the value of DNA microarray comparative genomic hybridization (array CGH) ... Antonio Breast Cancer Symposium. Using molecular test results from tumors with previously ...
(Date:12/2/2016)... ... December 01, 2016 , ... DrugDev believes ... standardization and a beautiful technology experience. All three tenets were on display at the ... trial leaders from over 40 sponsor, CRO and site organizations to discuss innovation and ...
(Date:12/2/2016)... , Dec. 1, 2016   SurePure, Inc. ... today that the Company has concluded an agreement with ... for a 90-day period to acquire units of the ... approximately USD 3.7 million.  Concurrently with ... Tamarack under which Tamarack will seek regulatory approvals in ...
Breaking Biology Technology:
(Date:11/30/2016)... CHICAGO , Nov. 30, 2016  higi ... a new partnership initiative targeting national brands, industry ... and reward their respective audiences for taking steps ... Since its inception in 2012, higi has built ... US, impacting over 38 million people who have ...
(Date:11/29/2016)... , Nov. 29, 2016   Neurotechnology ... and object recognition technologies, today released FingerCell ... fingerprint recognition solutions that run on low-power, ... template using less than 128KB of memory, ... devices that have limited on-board resources, such ...
(Date:11/28/2016)... 28, 2016 "The biometric ... 16.79%" The biometric system market is in the ... the near future. The biometric system market is expected ... at a CAGR of 16.79% between 2016 and 2022. ... biometric technology in smartphones, rising use of biometric technology ...
Breaking Biology News(10 mins):