Navigation Links
Brain inflammation likely key initiator to prion and Parkinson's disease
Date:12/4/2012

Prion diseases represent a family of neurodegenerative disorders associated with the loss of brain cells and caused by proteins called prions (derived from 'protein' and 'infection'). The diseases are found in both humans and animals, such as Creutzfeld-Jakob disease and mad cow disease respectively. Although mostly harmless, prions can transform into infectious agents, which accumulate in the brain and destroy the nervous tissue.

But how exactly does the accumulation of prions cause destruction of the brain? "Understanding the process by which prions destroy neurons is critical for finding a cure for prion disease", says Isaac Crespo, first author of the publication. He and his colleagues tackled this question with a computational approach: They ran their own computer programmes on experimental data generated by other research groups, and identified a set of 16 proteins that seems to control the onset of the disease. Interestingly, almost all of these proteins have known functions in neuro-inflammation.

"What we consider remarkable and constitutes our main finding, is the key role that neuro-inflammation plays in initiating prion disease. This finding is not only relevant for prion diseases, but also for other 'protein misfolding diseases' such as Parkinson's and Alzheimer diseases" says Prof. Dr. Antonio del Sol, group leader of the Computational Biology group.

Since its publication on October 15th, Crespo's paper was accessed so frequently, that it received the mark 'Highly Accessed', only awarded to articles that are downloaded very frequently. The strong interest that scientists are showing for these research findings reflects the urgency with which researchers are trying to understand prion diseases for which there is no cure until today.


'/>"/>

Contact: Isaac Crespo
isaac.crespo@uni.lu
352-466-644-6197
University of Luxembourg
Source:Eurekalert

Page: 1

Related biology technology :

1. Precisely engineering 3-D brain tissues
2. Remixed brain waves reveal soundtrack of the human brain
3. First Effective Treatment For Traumatic Brain Injury Reported by Institute of Neurological Recovery, Even Years After Injury
4. A better brain implant: Slim electrode cozies up to single neurons
5. Human brains share a consistent genetic blueprint and possess enormous biochemical complexity
6. MRI Interventions and Brainlab Launch European Commercialization Effort with First ClearPoint Case in Europe
7. Blue Brain Project accurately predicts connections between neurons
8. $1 Million Global B.R.A.I.N. Prize Announced by Israel Brain Technologies
9. Conference Challenges Left-brain, Right-brain Dichotomy
10. First detailed timeline established for brains descent into Alzheimers
11. Beyond Batten Disease Foundation and American Brain Foundation Launch First Clinical Research Fellowship to Treat and Cure Juvenile Batten Disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/19/2017)... ... September 19, 2017 , ... A best-selling ... early-stage tech companies. “Grit” author Angela Duckworth and her team at Character Lab ... is Cooley, an international law firm with decades of experience supporting high-growth companies ...
(Date:9/19/2017)... ValGenesis Inc., the global leader in Enterprise ... the strategic partnership with VTI Life Sciences (VTI). This ... using the latest technology available in the ValGenesis VLMS ... efficient and cost-effective validation services using ValGenesis VLMS. VTI ... VLMS system. The ...
(Date:9/19/2017)... ... September 19, 2017 , ... Band-LOK, LLC, an orthopedic medical ... two new patents have been allowed by the USPTO on the proprietary Tether ... continue to explore additional clinically-relevant designs for both the implants and the instrumentation. ...
(Date:9/18/2017)... (PRWEB) , ... September 18, 2017 , ... ... innovation and business process optimization firm for the life sciences and healthcare industries, ... ServiceMax Maximize 2017 conference. , What: Digital Transformation in Medical Device – The ...
Breaking Biology Technology:
(Date:4/17/2017)... , April 17, 2017 NXT-ID, Inc. (NASDAQ: ... announces the filing of its 2016 Annual Report on Form 10-K ... Commission. ... 10-K is available in the Investor Relations section of the Company,s ... the SEC,s website at http://www.sec.gov . 2016 Year ...
(Date:4/11/2017)... 11, 2017 No two people are ... the New York University Tandon School of Engineering ... found that partial similarities between prints are common ... mobile phones and other electronic devices can be ... vulnerability lies in the fact that fingerprint-based authentication ...
(Date:4/5/2017)... , April 4, 2017 KEY FINDINGS ... to expand at a CAGR of 25.76% during the ... is the primary factor for the growth of the ... https://www.reportbuyer.com/product/4807905/ MARKET INSIGHTS The global stem ... technology, application, and geography. The stem cell market of ...
Breaking Biology News(10 mins):