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Brain Cancer Researcher Eric Holland, One Of The World's Top Neurosurgeons, To Join Fred Hutch And UW Medicine
Date:4/1/2013

esearch focuses on developing mouse models of brain cancer that mimic the behavior of the disease in patients. His work with mouse models has led to clinical trials in glioma patients. He also has developed imaging strategies to follow mouse brain tumors as they develop – a powerful system that is used to test promising new drugs with potential benefit for patients.

Among Holland's discoveries:

  • He was the first to use a system of postnatal gene transfer to study brain cancer formation in mice, providing a model for the development of gliomas and medulloblastomas.
  • His laboratory was the first to demonstrate that stem cells are more sensitive to changes that can lead to cancer, providing clues to cancer development and its ability to evade treatment.
  • He was the first to demonstrate that the activity of a protein called Akt is elevated in human glioblastomas – a finding that provided major insights into the development of this cancer.

Holland received his medical degree from Stanford University and his doctorate in molecular biology from the University of Chicago. His postdoctoral training included work with two Nobel laureates: Paul Berg , Ph.D., a pioneer of recombinant DNA technology at Stanford University; and Harold Varmus, M.D., director of the National Cancer Institute and former director of the National Institutes of Health. Prior to Holland's arrival at Sloan-Kettering in 2001 he conducted brain surgery and basic research at the University of Texas MD Anderson Cancer Center. He is a member of the National Academy of Sciences' prestigious Institute of Medicine.

About Fred Hutchinson Cancer Research Center
At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovati
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