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Botanical compound could prove crucial to healing influenza
Date:7/18/2012

Building on previous work with the botanical abscisic acida, researchers in the Nutritional Immunology and Molecular Medicine Laboratory (NIMML) have discovered that abscisic acid has anti-inflammatory effects in the lungs as well as in the gut. The results will be published in the Journal of Nutritional Biochemistry.

"While the immune effects of abscisic acid are well understood in the gut, less was known about its effects in the respiratory tract. We've shown definitively that not only does abscisic acid ameliorate disease activity and lung inflammatory pathology, it also aids recovery and survival in influenza-infected mice," said Raquel Hontecillas, Ph.D., study leader, assistant professor of immunology at Virginia Bioinformatics Institute, and co-director of NIMML.

Influenza accounts for anywhere from 3,000 to 49,000 deaths per year in the United States alone, according to the Centers for Disease Control. It is difficult to treat if not caught immediately; antivirals usually become ineffective after the virus incubation period has passed and resistance to antiviral drugs poses a serious public health problem in the face of outbreaks. Abscisic acid, however, has been shown to be most effective at about seven to ten days into the infection, targeting the immune response rather than the virus itself, which many researchers feel is a safer way to reduce flu-associated fatalities.

"Most drugs for respiratory infections target the virus itself, rather than the inflammatory responses caused by the virus. Abscisic acid activates peroxisome proliferator-activated receptor-gamma, a receptor that aids in reducing inflammation, through a newly identified pathwaya but it does so without the side effects of other agonists like thiazolidinediones, which are known to have strong adverse side effects. The development of complementary and alternative Medicine approaches that modulate the host response has great promise in decreasing respir
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Contact: Tiffany Trent
ttrent@vbi.vt.edu
540-231-6822
Virginia Tech
Source:Eurekalert

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