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Boston Scientific Platinum Chromium ION™ Stent Demonstrates Positive Outcomes in PERSEUS Clinical Program
Date:11/8/2011

ividual safety measures of cardiac death, myocardial infarction (MI), and stent thrombosis remained low at two-year follow-up, demonstrating durable outcomes and successful transfer of the paclitaxel drug and polymer technology to the platinum chromium thin-strut platform.

Results were also presented from the PERSEUS Small Vessel trial, which compared the ION Stent in 223 patients with small vessels (greater than or equal to 2.25 to <2.75 mm diameter) to a matched historical control group of 125 patients treated with the Express® bare-metal stent.  The ION Stent demonstrated similar safety and superior performance at two years compared to the Express Stent with significantly lower propensity-adjusted rates of target lesion revascularization (TLR, 7.1 percent vs. 20.8 percent, p=0.009) in patients with lesions in small vessels.

PERSEUS-ATLAS Trial ComparisonIn an analysis of the PERSEUS and TAXUS ATLAS clinical trial programs, Dr. Kereiakes presented results that demonstrated safety outcomes favoring the ION (TAXUS Element) Stent compared to the Boston Scientific second-generation TAXUS® Liberte® Paclitaxel-Eluting Stent.  The study compared pooled patient-level data from 2,298 patients enrolled in the PERSEUS (ION Stent) and TAXUS ATLAS (TAXUS Liberte Stent) trials.  Propensity-matched results revealed that the ION Stent achieved significantly lower rates of MACE at two years (11.5 percent vs. 15.1 percent, p=0.04) and a numerically lower rate of TLF (8.2 percent vs. 11.0 percent, p=0.07), driven mainly by a reduction in MI (2.5 percent vs. 4.9 percent, p=0.02).  

"The significantly lower rates of MACE and MI in this propensity-matched analysis demonstrate that the platinum chromium alloy, new stent design and thinner struts of the ION Stent may favorably influence clinical outcomes," said Dr. Kereiakes.  "The PERSEUS trial results build confidence in this next-gener
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