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Boston Scientific Begins PLATINUM PLUS Trial for PROMUS(R) Element(TM) Stent System
Date:5/25/2010

NATICK, Massachussetts, May 26, 2010 /PRNewswire-FirstCall/ --

- Randomized Study of Nearly 3,000 Patients to Evaluate Company's Third-Generation Drug-Eluting Stent Technology

Boston Scientific Corporation (NYSE: BSX) today announced the initiation of the PLATINUM PLUS clinical trial, an investigator-sponsored research (ISR) study designed to compare the performance of the PROMUS(R) Element(TM) Everolimus-Eluting Coronary Stent System to the XIENCE PRIME(TM) Everolimus-Eluting Coronary Stent System. The PROMUS Element Stent, which received CE Mark in October 2009, is Boston Scientific's third-generation drug-eluting stent technology and incorporates a platinum chromium alloy with an innovative stent design and an advanced catheter delivery system.

PLATINUM PLUS is a prospective, randomized, multi-center clinical trial with planned enrollment of 2,980 patients at 50 sites in France, Germany, Italy, Spain and the U.K. It will evaluate coronary revascularization outcomes in an unrestricted patient population randomized (2:1) to receive a PROMUS Element Stent or XIENCE PRIME Stent. The primary endpoint is 12-month target vessel failure with planned follow-up out to 34 months. The trial is funded by a research grant from Boston Scientific and led by Principal Investigator Jean Fajadet, M.D., Clinic Pasteur, Toulouse, France and Co-Principal Investigator Eulogio Garcia, M.D., Clinico San Carlos,
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