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Boston Scientific Announces Exclusive Sponsorship and First Enrollments of MADIT-RIT Clinical Trial
Date:10/5/2009

NATICK, Mass., Oct. 5 /PRNewswire-FirstCall/ -- Boston Scientific Corporation (NYSE: BSX) today announced its exclusive sponsorship and first enrollments of the MADIT-RIT clinical trial. This new trial follows in the tradition of three previous landmark trials: MADIT, MADIT II and MADIT-CRT, each exclusively sponsored by Boston Scientific and conducted under the leadership of Principal Investigator Arthur J. Moss, M.D., Professor of Medicine at the University of Rochester.

MADIT-RIT is designed to determine which device programming strategy best minimizes the occurrence of unnecessary therapy in patients who have received an implantable cardioverter defibrillator (ICD) or cardiac resynchronization therapy defibrillator (CRT-D) and have no history of cardiac arrest. Unnecessary therapy has a significant impact on quality of life, especially for patients with no history of cardiac arrest.

The MADIT-RIT trial is a prospective, randomized study that will enroll 1,500 patients at approximately 75 centers globally.

"Clinical science has proved time and again that ICDs are highly effective in reducing death due to arrhythmias in high-risk cardiac patients," said Dr. Moss. "However, some patients receive unnecessary therapy, partly due to the programming of these devices at implant. MADIT-RIT will study the effects of programming on the occurrence of unnecessary therapy in these patients."

The first enrollments in this worldwide trial occurred last month in Graz, Austria at the Medizinische Universitatsklinik Graz (Burkert M. Pieske, M.D., and Daniel Scherr, M.D.); Basel, Switzerland at the Universitatsspital Basel (Beat Schaer, M.D., and Christian Sticherling, M.D.); Detroit, Michigan at the St. John Hospital and Medical Center (Luis Pires, M.D.); and Little Rock, Arkansas at Arkansas Cardiology (Steven Gree
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