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Boost for Malaria Vaccine Development by Combining Strengths of Dutch and American Researchers
Date:1/16/2008

f parasites treated with radiation, which renders the parasites unable to cause disease, but able to trigger a high, long-lasting degree of protection against malaria in the recipient."

According to Prof. Robert Sauerwein of Radboud University Nijmegen Medical Centre and principal investigator and coordinator of this project, Sanaria's methods for vaccine production are based on exceptional technological advances. The clinical tests will take place in Nijmegen, the Netherlands. Sauerwein: "The research being carried out by the groups at Radboud University Nijmegen Medical Centre and Leiden University Medical Center (research led by Dr. Chris Janse) will add a powerful new tool to the approach of rendering the parasite harmless, or attenuated. As opposed to weakening the parasites by radiation we wish to weaken them by genetically modifying them, leading to a similar result: an effective protection against malaria for humans."

Daan Crommelin, scientific director of TI Pharma states that this project will make a difference. "An effective malaria vaccine is important for millions of people in developing countries, especially for infants and children. Therefore this is a very important project based on the WHO Priority Medicines Program, in which malaria is specifically prioritized. With this unique cooperation between a front-running company such as Sanaria Inc. and two excellent Dutch medical centers, both leaders in the field, we expect major steps in the fight against malaria."

About Sanaria

Sanaria Inc. was founded in 2003. The company's primary mission is to develop and commercialize a malaria sporozoite vaccine against Plasmodium falciparum, the parasite responsible for more than 95 percent of malaria associated severe illness and death world-wide, and the malaria parasite for which there is the most significant drug resistance. Sanaria has overcome the initial technological and regulatory barriers and launched a clinical manufacturing
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SOURCE TI Pharma
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