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Biotech Hot in July Driven by Positive Drug Data and Acquisitions

SAN FRANCISCO, Aug. 3 /PRNewswire/ -- Biotech was "hot" in July driven by drug data, positive drug sales/earnings and partnering and M&A deals. As a result, the Burrill Biotech Select Index posted a solid monthly gain of 6.5 percent, mirroring the Dow and Nasdaq, which closed the month up 8.6 percent and 7.8 percent respectively marking their best performance for a July in years.

Helping fuel investors' enthusiasm was Human Genome Sciences whose shares jumped a whopping 395 percent in July on news of positive results for its experimental lupus injectable drug Benlysta, confounding all analysts' expectations and potentially clearing the way for the first new treatment against the inflammatory disease for over 50 years. Patients taking Benlysta plus a standard treatment for one year had reduced symptoms - including pain, rashes and infections - compared with patients taking standard treatment plus placebo. The study involved more than 860 patients in Asia, South America and Eastern Europe. Taking advantage of its strong share value, the company is planning a public offering of over $310 million.

Other major biotech movers included:

- Targacept closed out July up a whopping 338 percent on news that its drug candidate, TC-5214, significantly improved symptoms of major depressive disorder for patients who did not respond to an older drug, Forest Laboratories Inc.'s Celexa. TC-5214 was better than a placebo at improving an overall depression measurement, as well as reducing depression, irritability and severity of illness, and leading to better cognition and overall improvement.

- Orexigen Therapeutics shares jumped 54 percent in July after revealing that Contrave, a longer lasting form of two generic diet drug compounds, helped people lose weight in all three of its major clinical trials. That should clear the way for the San Diego biotech to file for approval to market the drug with the FDA.

- A marquee acquisition also caught the headlines as Medarex's shares soared 90 percent in July on news that Bristol-Myers Squibb was buying the Princeton, New Jersey-based biotech for $2.4 billion, or $16 per share in cash, representing a 90 percent premium. With the acquisition Bristol-Myers Squibb gains full rights to ipilimumab, an experimental drug for metastatic melanoma in late stage testing. The companies together have been developing the drug, which is also being studied in lung and prostate cancers. Bristol also gains rights to seven antibodies in clinical trials under Medarex's sole sponsorship and three other antibodies being co-developed with other partners, and rights to pre-clinical assets in various stages of development by Medarex - in particular, monoclonal antibodies focused in oncology and immunology.

It wasn't all good news for biotechs. Genzyme shares tumbled more than 6 percent in July following an announcement that the FDA plans to re-inspect a key manufacturing plant because the company did not take sufficient action to correct equipment maintenance and process control problems. Genzyme received an FDA warning letter in February citing manufacturing deficiencies at its Allston Landing manufacturing plant in Boston. The company said it took corrective action, and the FDA inspected the plant in May.

"The general markets have now experienced four excellent months of gains," said G. Steven Burrill, CEO, Burrill & Company, a San Francisco based global leader in life sciences with activities in Private Equity, Venture Capital, Merchant Banking and Media, "but while this month has been very encouraging for the health and biotech sector it is important to realize that this strong performance has been driven in large part by the tremendous stock gains of Human Genome Science, Targacept and Medarex.

"We don't yet believe biotech is fully back on track as many companies are still struggling to find the necessary funding to maintain their operations, almost half of US public biotechs have market caps below $100 million and we are seeing companies still consistently turning off their lights for the last time. It is important to remind ourselves that the biotech industry is undergoing a major transition, a process that will likely continue for many months yet.

"This is because we do not know how President Barack Obama's proposal for health care reform will fully impact the biotechnology industry and the status of biosimiliar legislation (follow-on biologics) is also still unresolved," noted Burrill, "and there are fears that these issues will drive the prices of innovative drugs lower and eat away at biotech company profits."

Biotech Industry Statistics for July

The monthly, subscription-based Burrill Report ( provides ongoing statistics and analysis on the 342 biotechs that are publicly traded on major US markets. Among the current data the publication reports that at the end of July this group of companies had an aggregate market cap of $345 billion (up 7 percent for the month). Also:

- There are 48 companies that have market caps greater than $1B (an increase of 11 percent since June)

- 152 public biotech companies (44%) have a market cap below $100 million

- Over 112 companies have announced a corporate restructuring by slashing staff and/or putting promising projects in the refrigerator. Recent announcements included:

- Celera cut 80 employees or 13 percent of its workforce

- Epix Pharmaceuticals entered bankruptcy and is winding down its operations.

- YTD the Burrill Biotech Select Index is up 4 percent

    July Biotech Indices

                                                           %        %
                     12/31    12/31   6/30    7/31      change    change
                     2007     2008    2009    2009      Month      YTD
     Select         331.52  300.33    294.09  313.23     6.51%     4.30%
     Cap  Biotech   437.71   379.7    424.71  452.87     6.63%    19.27%
     Mid-Cap        201.89  139.39    173.97  178.77     2.76%    28.25%
     Small Cap
                     137.6   78.35     82.51   96.13    16.51%    22.69%
     Genomics       104.29   59.69     65.73  106.28    61.69%    78.05%
     AgBio          198.83  127.72    135.12  151.35    12.01%    18.50%
     BioGreentech   158.66  106.12    133.21  142.45     6.94%    34.23%
     Diagnostic     159.43   138.3    131.47  131.89     0.32%    -4.63%

     Nutraceutical  593.04  369.24     408.08  461.84   13.17%    25.08%
    NASDAQ         2652.28 1577.03    1835.04  1978.5    7.82%    25.46%
    DJIA          13264.82 8776.39       8447 9171.61    8.58%     4.50%
     2000           766.03  499.95     508.28  556.94    9.57%    11.40%
     Biotech        786.5   647.15     697.17  870.25   24.83%    34.47%
     Pharma         338.52  272.84     262.11  278.82    6.38%     2.19%

About Burrill & Company

Founded in 1994, Burrill & Company is a San Francisco-based global leader in life sciences with activities in Venture Capital, Private Equity, Merchant Banking and Media. The Burrill family of venture capital funds has over $950 million under management and its merchant banking business is one of the industry leaders in life sciences transactions. Burrill is also the creator, sponsor and facilitator of over a dozen leading industry conferences worldwide and publisher of a range of bio-intelligence reports including the monthly Burrill Report, which tracks the progress of the global biotechnology industry and annual "State of the Industry" report the latest of which is Biotech 2009-Life Sciences: Navigating the Sea Change, the 23rd annual report on the industry. The 470-plus page book contains analysis and perspectives on the performance of the industry in 2008 and projections for 2009 and beyond. (

SOURCE Burrill & Company
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