Navigation Links
Bioprinting has promising future

Writing in the journal Science, Professor Derby of The School of Materials, looks at how the concept of using printer technology to build structures in which to grow cells, is helping to regenerate tissue.

Both inkjet and laser printer technology can be used to build the 3D scaffolds that cells can be grown in and also place the cells in these structures simultaneously. Professor Derby explains how bioprinting works: "Inkjet technology places the structure's material in small droplets, which then solidify. More droplets are then placed on top of the previous ones in a specific pattern. The structure is built using this method which is generally referred to as additive manufacture.

"Laser printing uses light to solidify the structure's material layer upon layer. These methods have allowed us to develop very complex scaffolds which better mimic the conditions inside the body."

The scaffold provides a surface for the cells to adhere, thrive and multiply. Both the scaffold material, composition and its internal architecture control the behaviour and well-being of the cells inside.

In his review article Professor Derby looks at experiments where porous structures have been made through bioprinting. They are then placed in the body to help act as a scaffold to encourage cell growth. The cells colonize the structure and it either dissolves or becomes part of the body.

This type of treatment can help patients suffering from problems such as cavity wounds. Clinical trials are currently taking place around the world to perfect this technology, and Professor Derby says it is moving towards becoming an established form of science.

Professor Derby also looks at how stem cells are being grown in printed structures that have been impregnated with certain chemicals. The chemicals are inserted during the printing process and can determine the type of cell the stem cells develop into. For example stem cells could be programmed to become cells that make up bone tissue or cartilage.

But there are limitations to the technology which is holding back breakthroughs such as the ability to grow an entire organ. Studies have found that it is very difficult to actually print the cells at the same time as making the structure that will house them. The stress on the cell as it goes through both the inkjet and laser process can damage the cell membrane. Cell survival rates have also been variable, ranging from between 40 to 95%.

The technology is also some way off progressing from an experimental platform to clinical practice. Whilst scaffolds are being clinically trialled, actually transplanting cells grown in an external structure into a patient is a more advanced process. It is still not possible at present to guarantee a consistent quality, which is required by medical device regulations.

But research is being carried out to grow external cells into tissue, such as a patch of skin, and transplant that into a patient. Professor Derby is currently working with Ear, Nose and Throat surgeons at the Manchester Royal Infirmary. He wants to use bioprinting to print cells without using a scaffold. The printed cells form a sheet that can be used for grafts inside the body, for example in the mouth or nose.

Professor Derby says: "It is very difficult to transplant even a small patch of tissue to repair the inside of the nose or mouth. Current practice, to transplant the patient's skin to these areas, is regarded as unsatisfactory because the transplants do not possess mucous generating cells or salivary glands. We are working on techniques to print sheets of cells that are suitable for implantation in the mouth and nose."

One area which Professor Derby's review article highlights for the future is the ability to grow structures which can model cancerous tumours. These could then be used to test new drugs, which it's hoped will advance the search for more effective treatments.

Writing the review article has encouraged Professor Derby that there is a strong future for bioprinting and whilst growing organs is still a long way off, the advances being made in this area are very promising.


Contact: Daniel Cochlin
University of Manchester

Related biology technology :

1. Organovo Announces Close of $15.2 Million Private Placement to Advance 3D Bioprinting for Medical Applications
2. Promising Data Presented on GenVec Malaria Program
3. University of Miami study finds RBAC to possess promising immunomodulating effects with respect to natural killer cell and cytokine activity
4. Founder of National Childrens Leukemia Unveiled Non-Embryonic Stem Cell Treatment Promising Cure for Cancer at GIL 2012: Europe
5. New 3-D transistors promising future chips, lighter laptops
6. S*BIOs Novel JAK2 Inhibitor Pacritinib (SB1518) and Histone Deacetylase Inhibitor Pracinostat (SB939) Demonstrate Promising Activity in Phase 2 Studies for Patients with Myelofibrosis (MF)
7. SAHYOG: Future of Bio-based Economy in India and European Union
8. New study reveals challenge facing designers of future computer chips
9. New discovery shows promise in future speed of synthesizing high-demand nanomaterials
10. ViThera Novel Approach Using Probiotics to Deliver Elafin Shows Promise as a Future Inflammatory Bowel Disease (IBD) Treatment
11. Epigenetics Holds Key to Healthier Future
Post Your Comments:
(Date:11/24/2015)... SHPG ) announced today that Jeff Poulton , ... Annual Healthcare Conference in New York City ... (1:30 p.m. GMT). --> SHPG ) announced today that ... Piper Jaffray 27 th Annual Healthcare Conference in ... at 8:30 a.m. EST (1:30 p.m. GMT). --> Shire ...
(Date:11/24/2015)... , Nov. 24, 2015  Twist Bioscience, ... that Emily Leproust, Ph.D., Twist Bioscience chief executive ... Healthcare Conference on December 1, 2015 at 3:10 ... in New York City. --> ... . Twist Bioscience is on Twitter. Sign ...
(Date:11/24/2015)... Nov. 24, 2015 /CNW Telbec/ - ProMetic Life Sciences Inc. ... that Mr. Pierre Laurin , President and Chief Executive ... the upcoming Piper Jaffray 27 th Annual Healthcare Conference ... December 1-2, 2015. st , at 8.50am ... meetings throughout the day. The presentation will be available live ...
(Date:11/24/2015)... MUNICH and NEW YORK , ... irst investment by Bristol-Myers Squibb in a ... Bristol-Myers Squibb Company in which the companies ... products in immuno-oncology and other areas of unmet medical need. ... Squibb in LSP 5, the latest LSP fund. This is ...
Breaking Biology Technology:
(Date:11/10/2015)...  In this report, the biomarkers market ... type, application, disease indication, and geography. The ... consumables, services, software. The type segments included ... biomarkers, and validation biomarkers. The applications segments ... drug discovery and development, personalized medicine, disease ...
(Date:11/9/2015)... Calif. , Nov. 9, 2015  Synaptics Inc. ... interface solutions, today announced broader entry into the automotive ... solutions that match the pace of consumer electronics human ... biometric sensors are ideal for the automotive industry and ... Europe , ...
(Date:10/29/2015)...   MedNet Solutions , an innovative SaaS-based eClinical ... research, is pleased to announce that it has been ... one of only three finalists for a 2015 ... Growing" category. The Tekne Awards honor Minnesota ... innovation and leadership. iMedNet™ eClinical ...
Breaking Biology News(10 mins):