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Bionovo to Present Recent Findings of BN107, its Anticancer Agent, at the 31st Annual San Antonio Breast Cancer Symposium
Date:12/12/2008

EMERYVILLE, Calif., Dec. 12 /PRNewswire-FirstCall/ -- Bionovo, Inc. (Nasdaq: BNVI) will present findings on the mechanism of action of its anti-cancer agent BN107 at the 31st Annual San Antonio Breast Cancer Symposium being held at the Henry B. Gonzalez Convention Center, San Antonio TX, December 10-14, 2008.

Bionovo's poster presentation will describe the pathway for cancer cell apoptosis (cell death) induced by BN107. As explained by Dr. Emma Shtivelman, Director of Cancer Research at Bionovo, the ability of BN107 to induce cancer cell death is distinct. BN107 induces apoptosis through the mitochondrial pathway. BN107 induces death only in estrogen receptor negative breast cancer cells. Our studies show that cholesterol depletion and disruption of lipid raft-mediated signaling is most likely responsible for the pro-apoptotic effect of BN107.

"BN107 mechanism of action and unique selective properties are a result of some of the biological differences exhibited uniquely by cancer cells. We believe BN107 will result in better selectivity to hormone independent tumors. Currently the only available treatment for this group, constituting 40% of women diagnosed with breast cancer, is chemotherapy. BN107, an oral drug candidate, should provide a chronic treatment option with a low toxicity profile," said Dr. Isaac Cohen, Chairman and CEO of Bionovo

Bionovo, Inc.

Bionovo is a pharmaceutical company focused on the discovery and development of safe and effective treatments for women's health and cancer, markets with significant unmet needs and billions in potential annual revenue. The company applies its expertise in the biology of menopause and cancer to design new drugs derived from botanical sources which have novel mechanisms of action. Based on the results of early and mid-stage clinical trials,
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SOURCE Bionovo, Inc.
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