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Biomarkers - Technologies, Markets and Companies
Date:11/30/2011

l disorders 115

Future prospects of biomarker-based drug development 116

The Biomarker Alliance 116

Molecular Libraries and Imaging Roadmap of NIH 117

Biomarkers Consortium 117

Pharmacogenomic biomarker information in drug labels 118

Concluding remarks on the future trends in biomarker development 118

5. Role of Biomarkers in Healthcare 121

Introduction 121

Biomarkers of inflammation 121

ESR and CRP as biomarkers of inflammation 122

Biomarkers of oxidative stress 122

1,4-dihydroxynonane-mercapturic acid 122

Oxidative DNA damage 123

Proteins as biomarkers of oxidative stress in diseases 123

Testing for oxidative stress 123

Biomarkers in metabolic disorders 123

Biomarkers of acute intermittent porphyria 123

Liver X receptors 124

Biomarkers of diabetes mellitus 124

Biomarkers of hyperglycemia 125

Biomarkers of diabetes-associated oxidative stress 125

Biomarkers of inflammation associated with diabetes 126

Biomarkers of renal complications in diabetes mellitus type 2 126

Biomarkers of diabesity 126

Glycosylated hemoglobin in diabetes mellitus 126

Glycated albumin as a biomarker of diabetes mellitus 127

Lack of C-peptide as biomarker of complications of diabetes type 1 127

Serum retinol binding protein 4 as biomarker of insulin resistance 127

Biomarkers of metabolic syndrome 128

Adiponectin 128

Biomarkers in immune disorders 129

Biomarkers relevant to organ transplantation 129

Biomarkers of graft versus host disease 129

Biomarkers of renal allograft failure 130

Biomarkers of renal transplant tolerance 131

Biomarkers of lung transplant rejection 132

Systemic lupus erythematosus 132

Current management and need for biomarkers 132

Role of collaborative efforts and databases of SLE biomarkers 133

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