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Biomarkers - Technologies, Markets and Companies
Date:11/30/2011

>Microarrays for analysis of miRNA gene expression 96

4. Biomarkers for Drug Discovery & Development 97

Introduction 97

Biomarker technologies for drug discovery 98

Proteomics-based biomarkers for drug discovery 98

Chemoproteomics 98

Activity-based chemical proteomics 98

Transcriptomics for drug discovery 99

AvalonRx® drug discovery platform 99

Metabolomics for drug discovery 99

Biomarkers and drug safety 100

Biomarkers of adverse drug reactions 100

Applications of biomarkers in drug safety studies 101

Genomic technologies for toxicology biomarkers 101

Proteomic technologies for toxicology biomarkers 102

Metabonomic technologies for toxicology biomarkers 102

Integration of genomic and metabonomic data to develop toxicity biomarkers 102

Toxicology studies based on biomarkers 103

Biomarkers of hepatotoxicity 104

Biomarkers of nephrotoxicity 105

Cardiotoxicity 106

Neurotoxicity 107

Applications of biomarkers for drug development 107

Application of metabonomics/metabolomics for drug development 107

Role of pharmacokinetic/pharmacodynamic biomarkers in drug development 108

Molecular imaging as a biomarker in drug development 109

Molecular imaging in preclinical studies 109

Molecular imaging in clinical trials 110

Prospects of molecular imaging in drug discovery and development 111

Biomarkers in clinical trials 111

NIH recommendations on the use of biomarkers in clinical trials 112

Advantages of biomarkers for drug development 113

Limitations and problems with use of biomarkers in clinical trials 113

Application of biomarkers by the pharmaceutical companies 114

Use of biomarkers in relation to stage of drug discovery and development 115

Drug development in cardiovascular disorders 115

Drug development in neurologica
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