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Biomarkers - Technologies, Markets and Companies

andem MS 52

Single-molecule mass spectrometry using a nanopore 52

Requirements for MS-based proteomic biomarker development 53

Protein tomography 53

Protein biochips/microarrays and biomarkers 53

Antibody-based biomarker discovery 54

Detection of biomarkers using peptide array technology 54

Discovery of biomarkers by MAb microarray profiling 54

Protein nanobiochip 55

Gene expression microarray data as a source of protein biomarkers 55

Quantification of protein biomarkers 55

Mass spectrometry for quantification of protein biomarkers 55

Real-time PCR for quantification of protein biomarkers 56

CyTOF for quantification of biomarkers 56

Search for biomarkers in body fluids 56

Challenges and strategies for discovey of protein biomarkers in plasma 57

3-D structure of CD38 as a biomarker 58

BD™ Free Flow Electrophoresis System 58

Isotope tags for relative and absolute quantification 58

Plasma protein microparticles as biomarkers 59

Proteome partitioning 59

Stable isotope tagging methods 60

Technology to measure both the identity and size of the biomarker 60

Targeted proteomic approaches 61

Biomarkers in the urinary proteome 61

Peptides in body fluids and tissues as biomarkers of disease 61

Analysis of peptides in bodily fluids 62

Serum peptidome patterns 62

SISCAPA method for quantitating proteins and peptides in plasma 63

Comparison of proteomic profiling technologies for discovery of biomarkers 63

Verification for interlaboratory reproducibility of protein biomarkers 63

Significance of similar protein biomarkers in different tissues 64

Glycomic technologies 65

Metabolomic technologies 65

Genome-wide association studies for identification of metabolic biomarkers 66

Lipid profiling 66

Mass spectrometry-based kits for di

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