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Biomarkers - Technologies, Markets and Companies
Date:11/30/2011

30

Metabolomics 30

Glycomics 30

Single nucleotide polymorphisms 31

Haplotyping 31

Cell biomarkers of disease 32

Stem cell biomarkers 32

Association of stem cell biomarkers with disease 32

Cancer stem cell biomarkers 33

Endoglin as a functional biomarker of stem cells 33

p75NTR as a biomarker to isolate adipose tissue-derived stem cells 33

Protein expression profile as biomarker of stem cells 33

STEMPRO? EZChek? for analysis of biomarkers of hESCs 34

SSEA-4 as biomarker of MSCs 34

Gaseous mediators as biomarkers of disease 34

Autoantibodies as biomarkers of autoimmune diseases 34

Comparison of various types of biomarkers 35

Biomarkers and systems biology 36

Systems biology approach to biomarker identification 37

Relation of biomarkers to other technologies and healthcare 37

Biomarkers and translational medicine 38

Limitations of use of biomarkers in healthcare 38

2. Technologies for Discovery of Biomarkers 41

Introduction 41

The ideal biomarker 41

Genomic technologies 41

Gene expression 41

Whole genome expression array 42

Gene expression profiling on whole blood samples 43

Profiling gene expression patterns of white blood cells 43

Tissue microarrays for study of biomarkers 43

Epigenomic technologies 44

Discovery of methylation biomarkers 44

Proteomic technologies 45

2D GE 46

Biomarker Amplification Filter 47

CellCarta® proteomics platform 47

Isotope-coded affinity tags 48

Liquid chromatography-MS/MS 48

Lucid Proteomics System 48

Magnetics beads for protein biomarker discovery 49

MASStermind™ 49

Mass spectrometry 49

2D PAGE and mass spectrometry 50

Imaging mass spectrometry 50

MALDI mass spectrometry for biomarker discovery 51

Quantitative t
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