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Biomarkers - Technologies, Markets and Companies
Date:11/30/2011

rs play a role in use of pharmacogenetics, pharmacogenomics and pharmacoproteomics for development of personalized medicine.

Many of the regulatory issues concerning biomarkers are related to genomics, proteomics, molecular diagnostics and pharmacogenomics/pharmacogenetics. Validation of biomarkers and their role in clinical trials is discussed.

Biomarker markets are estimated from 2010 to 2020 according to share of markets for various technologies and applications: proteomics, metabolomics, molecular diagnostics, drug discovery, clinical trials, and bioinformatics. Market values are further split according to therapeutic applications and major geographical areas. Unfulfilled needs in biomarkers are identified as well as the drivers for biomarker markets. Challenges facing the biomarker industry and strategies for developing biomarker markets are discussed.

A large number of companies with varying technical backgrounds are involved in biomarkers and 277 of these are profiled in part 2 of the report with classification into various categories.These also include major pharmaceutical companies. There is tabulation of 514 collaborations between companies and additional academic collaborations are mentioned in the individual profiles of companies. The report is supplemented by 1,000 references, 66 tables and 13 figures

TABLE OF CONTENTS

0. Executive Summary 21

1. Introduction 23

Definitions 23

Historical aspects of biomarkers 23

Classification of biomarkers 24

Biological marker as response to therapeutic intervention 25

Pharmacokinetic/pharmacodynamics biomarkers 25

Predictive biomarkers 25

Valid biomarkers 26

Types of biomarkers 26

Genes as biomarkers 26

Proteins as biomarkers 27

Proteomics 27

DNA biomarkers 28

Mitochondrial DNA 28

Mitochondrial mutations 28

RNA biomarkers 28

Transcriptomics 29

MicroRNAs
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