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Biomarkers of caloric restriction 180
Biomarkers of malnutrition 180
Proteomic biomarkers and nutrition 180
Vitamin deficiency as biomarker of disease 181
Vitamin D as a biomarker of disease 181
Vitamin B12 deficiency 181
Biomarkers of gene-environmental interactions in human disease 182
6. Biomarkers of Cancer 183
Introduction 183
The ideal biomarker for cancer 183
Single vs multiple biomarkers of cancer 184
Types of cancer biomarkers 184
HER3 as biomarker of cancer 185
DNA repair biomarkers 185
miRNAs as biomarkers in cancer 185
Circulating miRNAs for cancer detection 187
Diagnostic value of miRNA in cancer 187
Biomarkers of epigenetic gene silencing in cancer 187
Immunologic biomarkers of cancer 188
Molecular diagnostic techniques for cancer 188
Technologies for detection of cancer biomarkers 189
Genomic technologies for cancer biomarkers 189
Cold-PCR 189
Genome analysis at the molecular level 190
Sequencing-based approaches for detection of cancer biomarkers 190
Early detection of tumor suppressor gene mutations 190
Biomarkers of PTEN tumor suppressor gene status 191
HAAH as a biomarker for cancer 191
KRAS as a biomarker of cancer 192
Telomerase as a biomarker of cancer 192
Digital karyotyping for cancer biomarkers 192
LigAmp for detection of gene mutations in cancer 193
Mitochondrial DNA as a cancer biomarker 193
Tissue microarrays for study of cancer biomarkers 193
Molecular fingerprinting of cancer 194
Biomarkers of inflammation in cancer 195
Proteomic technologies for detecting biomarkers of cancer 195
2D PAGE 196
Antibody-based detection of protein biomarkers 196
Aptamer-based molecular probes for cancer biomarker discovery 197
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