Navigation Links
Biological tooth replacement -- a step closer
Date:3/8/2013

Scientists have developed a new method of replacing missing teeth with a bioengineered material generated from a person's own gum cells. Current implant-based methods of whole tooth replacement fail to reproduce a natural root structure and as a consequence of the friction from eating and other jaw movement, loss of jaw bone can occur around the implant. The research is led by Professor Paul Sharpe, an expert in craniofacial development and stem cell biology at King's College London and published in the Journal of Dental Research.

Research towards achieving the aim of producing bioengineered teeth bioteeth has largely focussed on the generation of immature teeth (teeth primordia) that mimic those in the embryo that can be transplanted as small cell 'pellets' into the adult jaw to develop into functional teeth.

Remarkably, despite the very different environments, embryonic teeth primordia can develop normally in the adult mouth and thus if suitable cells can be identified that can be combined in such a way to produce an immature tooth, there is a realistic prospect bioteeth can become a clinical reality. Subsequent studies have largely focussed on the use of embryonic cells and although it is clear that embryonic tooth primordia cells can readily form immature teeth following dissociation into single cell populations and subsequent recombination, such cell sources are impractical to use in a general therapy.

Professor Sharpe says: 'What is required is the identification of adult sources of human epithelial and mesenchymal cells that can be obtained in sufficient numbers to make biotooth formation a viable alternative to dental implants.'

In this new work, the researchers isolated adult human gum tissue from patients at the Dental Institute at King's College London, grew more of it in the lab, and then combined it with the cells of mice that form teeth. By transplanting this combination of cells into mice the resea
'/>"/>

Contact: Katherine Barnes
katherine.barnes@kcl.ac.uk
44-207-848-3076
King's College London
Source:Eurekalert

Page: 1 2

Related biology technology :

1. Tissue Culture Biologicals, Inc. Hires James D. Titus to Lead New Expansion and Branding Development Effort
2. Rigaku introduces the world’s most comprehensive biological SAXS system for the home lab
3. A possible answer for protection against chemical/biological agents, fuel leaks, and coffee stains
4. Novus Biologicals Hires David Eansor to Lead New Corporate-Development Effort
5. Uncovering the Meaning in Your NGS Data: Tackling the Biological Analysis and Interpretation of Sequence Variation
6. GenScript Announces Collaboration with AMDeC: Seeks to Decrease Biological Research Costs at NYC Area Institutions
7. Three Hertz Foundation Fellows Receive Presidential Honors; Leaders in Applied Physical, Biological and Engineering Sciences
8. Society of Biological Psychiatry and Elsevier Renew Publishing Agreement
9. PhoenixSongs Biologicals, Inc. Announces Enhanced Neural Lineage-specific Cell Culture Media Products Release
10. "Biological Control Industry Overview: Companies & Products" Edition 2 is Here. Critical information for Understanding the Global Biopesticide/Biocontrol Market
11. Biodetection 2012 Conference Brings Together Leading Organizations from Around the World to Address Challenges & Technology Advances in Detection and Identification of Biological Threats in Washington, DC from June 28-29, 2012
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/15/2014)... RedBrick Health , a fast-growing leader in consumer health ... EmblemHealth , the New York -based ... RedBrick Compass health assessment, combined with the RedBrick Journeys ... EmblemHealth is among the first health plans in the ...
(Date:1/15/2014)... The Microcompetition with Foreign DNA theory explains how ... latent viruses is the Epstein Barr Virus (EBV), and one ... is a chronic inflammatory disease that destroys the body’s joints. ... patients have high concentrations of EBV DNA in their bodies ...
(Date:1/15/2014)... TAIPEI , Jan. 15, 2014 TaiGen Biotechnology ... an exclusive agreement with R-Pharm, a leading Russian pharmaceutical ... in the Russian Federation , ... Commonwealth Independent States (CIS). Nemonoxacin is a novel antibiotic for ...
(Date:1/14/2014)... , Jan. 14, 2014 As pet owners drew up their ... of them wrote: "Take better care of my furry companion." Nowadays ... clothes and top-brand carrying cases to take the little canine or ... also feel compelled to buy some pricey toys at the pet ...
Breaking Biology Technology:EmblemHealth Selects RedBrick Health to Power its Next-Generation Health Engagement and Behavior Change System 2EmblemHealth Selects RedBrick Health to Power its Next-Generation Health Engagement and Behavior Change System 3Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 2Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 3TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 2TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 3TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 4New Year's Resolution: Give Pets the Gift of Top-Notch Health Care 2
... Sequenom, Inc. (NASDAQ: SQNM ), a ... announced the acceptance for publication of the manuscript, "Clinical ... of Developing Choroidal Neovascular Age-related Macular Degeneration." The article ... Genomics . The study, conducted by the company,s wholly-owned ...
... who design new materials often struggle to understand ... including polymers and biological materials change upon cooling ... a tar-like consistency at intermediate temperatures, then become ... lower temperatures. Scientists have long sought a molecular-level ...
... Researchers at Northwestern University have created a new ... invisible in the terahertz range. Though this ... the visible spectrum, it could have implications in ... by Cheng Sun, assistant professor of mechanical engineering ...
Cached Biology Technology:Sequenom Announces Publication Acceptance of Manuscript From Age-related Macular Degeneration Validation Study 2Sequenom Announces Publication Acceptance of Manuscript From Age-related Macular Degeneration Validation Study 3Sequenom Announces Publication Acceptance of Manuscript From Age-related Macular Degeneration Validation Study 4Sequenom Announces Publication Acceptance of Manuscript From Age-related Macular Degeneration Validation Study 5Sequenom Announces Publication Acceptance of Manuscript From Age-related Macular Degeneration Validation Study 6Understanding how glasses 'relax' provides some relief for manufacturers 2Researchers create terahertz invisibility cloak 2
(Date:7/9/2014)... nature,s ability to split the water molecule during ... artificial photosynthesis for clean, green and renewable energy ... scientists led by researchers with the Lawrence Berkeley ... Accelerator Laboratory. , Working at SLAC,s Linac ... x-ray laser, the researchers were able to take ...
(Date:7/9/2014)... about the prevalence of antibiotic-resistant illness, Case Western ... to disabling disease: blocking bacteria,s access to iron ... bacterial siderophore, a small molecule, captures iron from ... as well as how the body launches ... findings appear in a recent edition of ...
(Date:7/9/2014)... first-ever global census of Adlie penguins shows that ... 53 percent larger than previously estimated. Adlie penguins ... to monitor and understand the effects of climate ... By using high-resolution satellite imagery, researchers from Stony ... a new method that permits regular monitoring of ...
Breaking Biology News(10 mins):Postcards from the photosynthetic edge 2Postcards from the photosynthetic edge 3Bacteria hijack plentiful iron supply source to flourish 2New study finds that Adélie penguin population is on the rise 2New study finds that Adélie penguin population is on the rise 3
... researchers report that common assumptions employed in the generation ... can lead to seriously flawed conclusions about gene activity ... biological research. "Expression analysis is one of the ... Member Richard Young. "So we are concerned that flawed ...
... new collaborative project among researchers from Uppsala University in ... first time, demonstrated experimentally the evolutionary force behind the ... of seed beetle. This mechanism is revealed ... Current Biology . The experiments leading to this ...
... PITTSBURGHWhile Omega-3 essential fatty acidsfound in foods like wild ... their effects on the working memory of healthy young ... the first study of its kind, researchers at the ... ages 18-25 can improve their working memory even further ...
Cached Biology News:Whitehead scientists identify major flaw in standard approach to global gene expression analysis 2Size does matter in sexual selection, at least among beetles 2Omega-3 intake heightens working memory in healthy young adults 2Omega-3 intake heightens working memory in healthy young adults 3
Adhesion Molecule Antibodies...
Mouse monoclonal [7C6] to Bcr-abl ( Abpromise for all tested applications). SwissProtID: P11274...
Anti-Bcl-G (CT) Host: rabbit polyclonal Species Reactivity: human, mouse, rat Applications: WB, IHC Storage: 4C...
Anti-Mouse IgM Heavy Chain:FITC, Clone LO-MM-9, Monoclonal Antibody...
Biology Products: