Navigation Links
Biological electron transfer captured in real time
Date:3/3/2008

Two research teams led by Dr. Michael Verkhovsky and Prof. Mrten Wikstrm of the Institute of Biotechnology of the University of Helsinki have for the first time succeeded in monitoring electron transfer by Complex I in real time. In the future, this work might, for example, have medical relevance, because most of the maternally inherited so-called mitochondrial diseases are caused by dysfunction of Complex I.

This achievement required developing and building of a special device by which the enzyme-catalysed electron transfer could be captured at different time points by stopping the reaction at liquid nitrogen temperatures, on a microsecond (one millionth of a second) time scale. The electrons are very small elementary particles, which is why their transfer is very fast. This work is published this week in the prestigious journal of the American National Academy of Sciences (Proc. Natl. Acad. Sci.). The results give certain hints of the function of Complex I at the molecular level.

Electron transfer is central to many chemical reactions in the cell. It has particular functional importance in cell respiration, which in eukaryotes takes place in the inner mitochondrial membrane, and in the cell membrane of prokaryotes. In cellular respiration molecules stemming from food are oxidised to carbon dioxide, and the electrons liberated in the process are "fed" into the so-called respiratory chain, which consists of three successive membrane-bound enzyme complexes, finally to react with the oxygen we breathe, which is reduced to water using these electrons.

The purpose of electron transfer in cellular respiration is to release the major part of the energy of foodstuffs and to conserve it in a suitable form, ATP (adenosine triphosphate), which the cell may use in its energy-requiring reactions (e.g. biosynthesis, active transport, mechanical work), which are essential e.g. during fetal development and growth, in neural and kidney function, m
'/>"/>

Contact: Mrten Wikstrm
marten.wikstrom@helsinki.fi
358-919-158-000
University of Helsinki
Source:Eurekalert

Page: 1 2

Related biology technology :

1. Neurobiological Technologies, Inc. Reports Receipt of Notice From Nasdaq
2. Tutogen Medical, Inc. and Zimmer Holdings, Inc. Announce Agreement for International Distribution of Biological Products
3. Zimmer and Tutogen Announce Agreement for International Distribution of Biological Products
4. Sigma-Aldrich and Ingenuity Systems Announce Partnership to Create E-Commerce Search Solution Based on Biological Knowledge
5. Midwest Research Institute Launches Center for Biological Safety and Security (CBS2)
6. Neurobiological Technologies, Inc. Reports Fourth Quarter and Fiscal Year-End Financial Results for 2007 Announces 1-for-7 Reverse Stock Split
7. BioReliance Corporation Launches iNet(TM) for Online Results Tracking of Biological Safety Tests
8. Neurobiological Technologies, Inc. (Nasdaq: NTIID)
9. When proteins, antibodies and other biological molecules kiss, a new kind of biosensor can tell
10. When proteins, antibodies and other biological molecules kiss, a new kind of biosensor can tell
11. Microtest Offers Free White Paper: Virus Testing for Biological Products: Partnering With a Contract Lab
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/11/2014)... MD (PRWEB) September 12, 2014 ... (LIMS), radio-frequency identification (RFID) solutions and sample management ... 5.1. , RURO completed work on the most ... August and it has already seen mass adoption, ... major release of version 5.0 brought an entirely ...
(Date:9/11/2014)... this week in Science , the collaboration led ... laureate Sir Andre Geim report a material in which ... similar to sailboats driven diagonally to the wind. , ... made from carbon but with a difference. It ... placing it on top of boron nitride, also known ...
(Date:9/11/2014)... Francisco, California (PRWEB) September 11, 2014 ... of software and IT systems that support clinical ... Annotation™ (GVA™) Service that now supports the interpretation ... resulting in a single, user-friendly report that contains ... been used toward cancer treatment planning and support ...
(Date:9/11/2014)... 11, 2014 Genera Energy Inc ... and supply chain advancements, recently introduced its newest feedstock ... delivers a consistent biomass product to a customer’s specifications ... lower cost. , “After producing and harvesting a ... to convert a field crop into a uniform format ...
Breaking Biology Technology:Limfinity® Version 5.1 Available 2New species of electrons can lead to better computing 2CollabRx Launches Expansion of Its Genetic Variation Annotation Service to Support Copy Number Variation (CNV) Data 2CollabRx Launches Expansion of Its Genetic Variation Annotation Service to Support Copy Number Variation (CNV) Data 3Genera Energy’s BIN-SPEC™ Reduces Biomass Feedstock Variability 2Genera Energy’s BIN-SPEC™ Reduces Biomass Feedstock Variability 3
... By developing software that uses 3-D models of proteins involved ... has identified several new molecules that may ease the symptoms ... the team predict how well a given molecular structure will ... fibrosis. To test the predictions, the scientists synthesized the molecules ...
...   On May 21-23, 2012, Diversity Alliance for ... mentor, and develop minority-, woman-, veteran/service-disabled-, HUBZone-, and ... annual networking conference and EXPO event.  Bret Michaels, ... address the conference held at the Renaissance Newark ...
... April 19, 2012 /PRNewswire-Asia/ -- GenScript USA Inc., an internationally ... Gene Synthesis service in the global market on Dec. 22, ... rates ever since its kick-off. "Two decades ago, ... obtain the construct using conventional PCR cloning technologies in my ...
Cached Biology Technology:Computer-designed molecules point to new therapy for cystic fibrosis 2Computer-designed molecules point to new therapy for cystic fibrosis 3Music Legend And Health Advocate Bret Michaels To Address Diversity Alliance For Science 2012 National Conference And EXPO 2Music Legend And Health Advocate Bret Michaels To Address Diversity Alliance For Science 2012 National Conference And EXPO 3GenScript Rush Gene Synthesis - Driving Molecular Biology Research Faster 2
(Date:9/11/2014)... Sept. 11, 2014 UT Southwestern Medical Center, 2M ... advance research and drug development for neurodegenerative disorders caused ... This week, UT Southwestern researchers published a new paper ... that has been shown to help in various animal ... compounds to Dallas-based 2M Companies. 2M and Calico have ...
(Date:9/11/2014)... sheds light on the origin of bird species in ... of Natural Science Director and Roy Paul Daniels Professor ... an international team of researchers funded by the National ... challenging the view that speciation the process by ... to geological and climatic changes to the landscape. , ...
(Date:9/11/2014)... -- NXT-ID, Inc. (Nasdaq: NXTD ), a biometric ... today that its shares of common stock and warrants to ... Market. The common stock and warrants and will trade under ... Company,s common stock will no longer be quoted on the ... be traded on Nasdaq. About NXT- ID ...
Breaking Biology News(10 mins):Calico enters into exclusive collaboration with 2M to develop UTSW technology 2Calico enters into exclusive collaboration with 2M to develop UTSW technology 3LSU scientists lead research on speciation in the tropics 2
... , This press release is available in ... , Monterrey, 13 November 2012Today, the Nuevo Len state ... for Environmental Cooperation (CEC), launched a revamped air quality ... This CEC initiative, developed in coordination with Canadian, ...
... As the brain develops, each neuron must find its way ... of links the brain needs to function. Like the wiring ... functioning for an entire segment of the brain. A ... School of Medicine reveals how some nerve cells, called interneurons, ...
... Georgia, Harvard Medical School and the University of Utah have ... blood cell formation. Heme is the deep-red, iron-containing component of ... oxygen in the blood. The study was published ... print edition of the journal Nature . The findings ...
Cached Biology News:State of Nuevo León first to benefit from improved nationwide air quality information system 2Watching the developing brain, scientists glean clues on neurological disorder 2Nature study reveals loss of essential blood cell gene leads to anemia 2
...
... Lyophilized. Lyophilized from 2 mM sodium ... human liver. Cathepsin D is a major ... as a 52 kDa proenzyme. Overexpression of ... associated with higher risk of relapse and ...
... Grade Thrombin is a highly purified preparation ... with appropriate vectors. The preparation is functionally ... is free of detectable contaminating proteases. Prepared ... by certified tests to be negative for ...
Rat Hepatocytes (RH) (>3,000,000 cells)...
Biology Products: