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Bioheart Founder, Howard J. Leonhardt, Becomes Chairman of the Board of Directors
Date:3/17/2008

science that we believe will assist our efforts to commercialize our product candidates."

About MyoCell(R)

Bioheart's lead product candidate, MyoCell, is an innovative clinical cell therapy designed to populate regions of scar tissue within a patient's heart with living muscle tissue for the purpose of improving cardiac function in chronic heart failure patients. MyoCell uses adult stem cells that are precursors to muscle cells, or myoblasts, which are derived from the patient's own body. When injected into scar tissue within the heart wall, myoblasts have shown to be capable of engrafting in the damaged tissue and differentiating into mature muscle cells. The core technology used in MyoCell has been the subject of human clinical trials conducted over the last seven years and animal studies conducted over the last twenty years. Our most recent clinical trials of MyoCell include the SEISMIC Trial, a 40-patient Phase II clinical trial in various countries in Europe and the MYOHEART Trial, a completed 20-patient Phase I dose escalation trial in the United States. Final results of the MYOHEART Trial were announced in January 2008. The FDA recently cleared us to proceed with a multicenter Phase II/III trial for MyoCell in the United States, named the MARVEL Trial, which will enroll up to 330 patients.

About Bioheart, Inc.

Bioheart, Inc. is a biotechnology company focused on the discovery, development and, subject to regulatory approval, commercialization of autologous cell therapies for the treatment of chronic and acute heart damage. Its lead product candidate, MyoCell, is an innovative clinical cell therapy designed to populate regions of scar tissue within a patient's heart with autologous muscle cells, or cells from the patient's body, for the purpose of improving cardiac function in chronic heart failure patients. The company's pipeline includes multiple product candidates for the treatment of heart damage, including Bioheart Acute Cell
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SOURCE Bioheart, Inc.
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