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Biochip mimics the body to reveal toxicity of industrial compounds
Date:12/17/2007

fast screen of potential toxicity of chemicals and drug candidates on different types of human cells.

In an earlier paper published in a Jan. 25, 2005, edition of PNAS, the team introduced the MetaChip. The biochip mimics the metabolic reactions of the human liver, where chemicals and drugs are processed in the body. Depending on the compound, a seemingly benign chemical like acetaminophen can become highly toxic when metabolized by the liver. Because of differences in the type and amount of their drug-metabolizing enzymes, most of which are in the liver, individuals can metabolize a drug or other chemical compound differently. What is harmless to one person may be toxic to another. By arranging the ratio of enzymes on the MetaChip, scientists could develop a personalized chip to determine how toxic a drug might be to different people.

"We are still a ways off from personalized medicine, but the MetaChip offers that future possibility," Dordick said. When coupled with the new DataChip, the two chips could someday be used to determine the levels and combinations of drugs that are safe and effective for each individual patient, Clark explains.


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Contact: Gabrielle DeMarco
demarg@rpi.edu
518-276-6542
Rensselaer Polytechnic Institute  
Source:Eurekalert

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