Navigation Links
BioNanomatrix Announces Issuance of Key Nanofluidics Patent Enabling Single Molecule Whole Genome Analysis

-Covers Integration of Nanofluidic Channels into Sample Analysis Systems-

PHILADELPHIA, Sept. 24 /PRNewswire/ -- BioNanomatrix, Inc., a company developing breakthrough nanoscale whole genome imaging and analytic platforms for clinical genetics, cancer diagnostics and biomedical research, today announced the issuance of a patent for a key element of the company's whole genome analyzer. The patent covers a novel technique for the integration of nanofluidic channels with sample delivery systems, enabling single molecules of DNA, RNA or other proteins to be separated out from standard laboratory samples for direct imaging and analysis. The technology makes possible the isolation and linearization of intact multi-megabase DNA in a standardized format for molecule-by-molecule gene haplotyping, mapping and sequencing applications.

"The issuance of this fundamental broad patent is a major milestone for BioNanomatrix," said Dr. Han Cao, the company's chief scientific officer. "Single molecule analysis of DNA and other proteins is central to the unprecedented capabilities of our whole genome analytic platform. This new patent covers our unique ability to integrate nanofluidic channels into our sample delivery systems, enabling our NANOANALYZER(R) system to rapidly and efficiently separate out genomic length DNA from conventional laboratory samples and direct it into nanoscale channels for live, continuous molecule- by-molecule analysis."

Single molecule analysis of intact native DNA has been limited by the difficulty of stretching out and handling these long molecules. To address this issue, a Princeton University research team, including Dr. Cao, developed a simple approach that allows the construction of hundreds of thousands of enclosed, parallel nanofluidic channels on a single surface, using a gradient structured interface to gradually guide the biologically active molecules into the nanoscale channels. This simple technique is ideally suited for multiplexed parallel processing for applications from genotoxicity analyses to DNA sequencing.

Dr. Michael Boyce-Jacino, president and CEO of BioNanomatrix added, "The approach covered in this new patent functions like the toll booth on a highway, serving in real time to separate and organize the random mix of vehicles comprising the flow of traffic down into single elements. Similarly, our nanofluidics chip system sorts the random flow of sample components down to the single molecule level, thereby enabling structural and functional analyses that would otherwise not be possible."

The NANOANALYZER is an integrated system that for the first time enables pan-genomic identification and analysis on a molecule-by-molecule basis, delivering single molecule sensitivity in a highly parallel format. It is designed to provide ultra high-resolution analyses of DNA, RNA and other proteins more rapidly, comprehensively and cost effectively than currently available approaches, with potential applications in diagnostics, personalized medicine and biomedical research.

US Patent No.: US 7,217,562 B2, Cao et al., May 15, 2007 was issued to Princeton University. BioNanomatrix is the exclusive licensee of the technology covered by this patent.

About BioNanomatrix

BioNanomatrix is developing breakthrough nanoscale whole genome imaging and analytic platforms for applications in clinical genetics, cancer diagnostics and other biomedical applications. The company is applying its expertise in nanochips, nanodevices and nanosystems to develop its patented platform technology to provide fast, comprehensive, and low-cost analysis of genomic, epigenomic and proteomic information with sensitivity at the single cell/single molecule level. BioNanomatrix' technologies are licensed exclusively from Princeton University. Founded as a spin-out of Princeton University in 2003, the company is headquartered in Philadelphia, Pennsylvania. For more information, visit:


For BioNanomatrix

Barbara Lindheim

GendeLLindheim BioCom

212 918-4650

SOURCE BioNanomatrix
Copyright©2007 PR Newswire.
All rights reserved

Related biology technology :

1. Speaker announces business members of IT Task Force
2. Doyle announces technology tax credits for Berbee
3. Doyle announces new energy, global warming policies
4. Doyle announces $80M renewable energy strategy
5. GE announces first installation of Discovery VCT
6. UWM announces winners of RGI awards
7. Third Wave announces two senior management appointments
8. Mirus announces new method for making antibodies
9. Merge announces sofware updates, upcoming acquisition
10. Small Tree announces ethernet solution for Apple Xserv G5
11. TEKLYNX International announces new RFID software
Post Your Comments:
(Date:11/25/2015)... --> ... 2020 report analyzes that automating biobanking workflow will ... long-term samples, minimizing manual errors, improving the workflow ... errors such as mislabeling or inaccurate sample barcoding ... a vital role in blood fractionation, DNA extraction, ...
(Date:11/25/2015)... , November 25, 2015 Studies ... and human plaque and pave the way for more effective ... in cats     --> ... commonly diagnosed health problems in cats, yet relatively little was ... Two collaborative studies have been conducted by researchers from the ...
(Date:11/25/2015)... 25, 2015 /PRNewswire/ - Aeterna Zentaris Inc. (NASDAQ:  AEZS; ... and prospects remain fundamentally strong and highlights the ... recently received DSMB recommendation to continue the ZoptEC ... of the final interim efficacy and safety data ... in men with heavily pretreated castration- and Taxane-resistant ...
(Date:11/25/2015)... The Global Genomics Industry ... and in-depth study on the current state of ... ) , The report provides ... classifications, applications and industry chain structure. The Genomics ... including development trends, competitive landscape analysis, and key ...
Breaking Biology Technology:
(Date:11/10/2015)... , Nov. 10, 2015  In ... on the basis of product, type, application, ... included in this report are consumables, services, ... report are safety biomarkers, efficacy biomarkers, and ... this report are diagnostics development, drug discovery ...
(Date:11/9/2015)... , Nov. 9, 2015  Synaptics Inc. (NASDAQ: ... today announced broader entry into the automotive market with ... match the pace of consumer electronics human interface innovation. ... are ideal for the automotive industry and will be ... Europe , Japan ...
(Date:10/29/2015)... MINNETONKA, Minn. , Oct. 29, 2015   ... that supports the entire spectrum of clinical research, is ... the Minnesota High Tech Association (MHTA) as one of ... in the "Software – Small and Growing" category. The ... and individuals who have shown superior technology innovation and ...
Breaking Biology News(10 mins):