Navigation Links
BioNanomatrix Announces Issuance of Key Nanofluidics Patent Enabling Single Molecule Whole Genome Analysis
Date:9/24/2007

-Covers Integration of Nanofluidic Channels into Sample Analysis Systems-

PHILADELPHIA, Sept. 24 /PRNewswire/ -- BioNanomatrix, Inc., a company developing breakthrough nanoscale whole genome imaging and analytic platforms for clinical genetics, cancer diagnostics and biomedical research, today announced the issuance of a patent for a key element of the company's whole genome analyzer. The patent covers a novel technique for the integration of nanofluidic channels with sample delivery systems, enabling single molecules of DNA, RNA or other proteins to be separated out from standard laboratory samples for direct imaging and analysis. The technology makes possible the isolation and linearization of intact multi-megabase DNA in a standardized format for molecule-by-molecule gene haplotyping, mapping and sequencing applications.

"The issuance of this fundamental broad patent is a major milestone for BioNanomatrix," said Dr. Han Cao, the company's chief scientific officer. "Single molecule analysis of DNA and other proteins is central to the unprecedented capabilities of our whole genome analytic platform. This new patent covers our unique ability to integrate nanofluidic channels into our sample delivery systems, enabling our NANOANALYZER(R) system to rapidly and efficiently separate out genomic length DNA from conventional laboratory samples and direct it into nanoscale channels for live, continuous molecule- by-molecule analysis."

Single molecule analysis of intact native DNA has been limited by the difficulty of stretching out and handling these long molecules. To address this issue, a Princeton University research team, including Dr. Cao, developed a simple approach that allows the construction of hundreds of thousands of enclosed, parallel nanofluidic channels on a single surface, using a gradient structured interface to gradually guide the biologically active molecules into the nanoscale channels. This simple technique is ideally suited for multiplexed parallel processing for applications from genotoxicity analyses to DNA sequencing.

Dr. Michael Boyce-Jacino, president and CEO of BioNanomatrix added, "The approach covered in this new patent functions like the toll booth on a highway, serving in real time to separate and organize the random mix of vehicles comprising the flow of traffic down into single elements. Similarly, our nanofluidics chip system sorts the random flow of sample components down to the single molecule level, thereby enabling structural and functional analyses that would otherwise not be possible."

The NANOANALYZER is an integrated system that for the first time enables pan-genomic identification and analysis on a molecule-by-molecule basis, delivering single molecule sensitivity in a highly parallel format. It is designed to provide ultra high-resolution analyses of DNA, RNA and other proteins more rapidly, comprehensively and cost effectively than currently available approaches, with potential applications in diagnostics, personalized medicine and biomedical research.

US Patent No.: US 7,217,562 B2, Cao et al., May 15, 2007 was issued to Princeton University. BioNanomatrix is the exclusive licensee of the technology covered by this patent.

About BioNanomatrix

BioNanomatrix is developing breakthrough nanoscale whole genome imaging and analytic platforms for applications in clinical genetics, cancer diagnostics and other biomedical applications. The company is applying its expertise in nanochips, nanodevices and nanosystems to develop its patented platform technology to provide fast, comprehensive, and low-cost analysis of genomic, epigenomic and proteomic information with sensitivity at the single cell/single molecule level. BioNanomatrix' technologies are licensed exclusively from Princeton University. Founded as a spin-out of Princeton University in 2003, the company is headquartered in Philadelphia, Pennsylvania. For more information, visit: http://www.BioNanomatrix.com.

Contact:

For BioNanomatrix

Barbara Lindheim

GendeLLindheim BioCom

212 918-4650


'/>"/>
SOURCE BioNanomatrix
Copyright©2007 PR Newswire.
All rights reserved

Related biology technology :

1. Speaker announces business members of IT Task Force
2. Doyle announces technology tax credits for Berbee
3. Doyle announces new energy, global warming policies
4. Doyle announces $80M renewable energy strategy
5. GE announces first installation of Discovery VCT
6. UWM announces winners of RGI awards
7. Third Wave announces two senior management appointments
8. Mirus announces new method for making antibodies
9. Merge announces sofware updates, upcoming acquisition
10. Small Tree announces ethernet solution for Apple Xserv G5
11. TEKLYNX International announces new RFID software
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/17/2017)... , Feb. 17, 2017  If only ... tumor had a mutation-conferring resistance to chemotherapy, thousands ... genomics research has focused on finding these mutations ... even from circulating tumor DNA in blood — ... oncology therapeutics. Unfortunately, however, detecting these ...
(Date:2/16/2017)... ... 2017 , ... Avomeen & MichBio will be hosting a BioMixer next week ... Analytical Services (4840 Venture Dr., Ann Arbor, Michigan 48108). BioMixers are a casual, ... interact with peers, make new connections and talk bio biz. , Cost:, ...
(Date:2/16/2017)... , Feb. 16, 2017  ArmaGen, Inc., ... groundbreaking therapies to treat severe neurological disorders, today ... treated with AGT-181, the company,s investigational therapy for ... known as mucopolysaccharidosis type I, or MPS I). ... proof-of-concept (POC) study, presented today at the 13 ...
(Date:2/16/2017)... 16, 2017 Patient Care ... innovative telemedicine application, new and leading edge therapies ... a boom worldwide. The healthcare sector as whole ... services and new therapies for companies such as ... Cellectar Biosciences, Inc. (NASDAQ: CLRB ), ...
Breaking Biology Technology:
(Date:2/7/2017)... , Feb. 7, 2017   MedNet Solutions , ... entire spectrum of clinical research, is pleased to announce ... , its innovative, highly flexible and award winning eClinical ... customers. iMedNet is a proven Software-as-a-Service (SaaS) ... Data Capture (EDC), but also delivers an entire suite ...
(Date:2/3/2017)... Biomedical Research Institute announced that its Board of Trustees has ... Institute,s new President and CEO. Dr. Schlesinger will take the ... currently the Chair of the Department of Microbial Infection and ... at Ohio State University. "We are delighted to ... Texas Biomed," said Dr. James O. Rubin , Board ...
(Date:2/2/2017)... Feb. 1, 2017  Central to its deep ... advances worldwide, The Japan Prize Foundation today announced ... have pushed the envelope in their respective fields ... Three scientists are being recognized with the 2017 ... not only contribute to the advancement of science ...
Breaking Biology News(10 mins):