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BioNano Genomics Announces The Purchase Of The Irys System By The Chinese Academy Of Sciences And Tel Aviv University
Date:10/25/2013

hnologies closely. Integration of short-read, next-generation sequencing with long-range physical maps has long been the standard of genomics. Today, Irys has started the last step of genome characterization in a way that researchers and practitioners originally envisioned. Most of these are in a category of de novo non-model species. We will not settle for anything less than the complete picture."

At Tel Aviv University, Dr. Yuval Ebenstein leads the NanoBioPhotonics Lab and will oversee the adoption of Irys. His team is advancing technologies to directly visualize the individual epigenetic modifications in an individual genome. Epigenetics is the study of how gene expression is regulated, via proteins, methylation and other modifications, without altering the underlying DNA sequence. By creating genome maps from individual DNA molecules, up to 1 million base pairs in length, they are unlocking important genetic and epigenetic information about how genes are activated or silenced.  Knowing how and why genes are turned on and off is significant to understanding many aspects underlying basic biology, including development, evolution and human disease.

"Next generation sequencing is advancing the genomic exploration in all fields of biology, but it fails to extract the full range of information associated with genetic material," said Yuval Ebenstein, Ph.D., Senior Lecturer, School of Chemistry, Tel Aviv University. "By directly visualizing DNA, we are able to get important insights into genome structural variation and epigenetic marks that are not accessible through sequencing or DNA arrays."

The Chinese Academy of Sciences and the Tel Aviv University are among the latest to adopt the Irys System. Others include the New York Genome Center, who are using their Irys for human and cancer genomics, UC San Francisco, for genomic investigations of a range of species from vi
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