Navigation Links
BioMarin Licenses Technology From Leading Cystic Fibrosis Research Laboratory at the University of California, San Francisco
Date:8/22/2007

Molecular Chaperones Target Underlying Defect in Cystic Fibrosis; CFTR

Folding and Transport

NOVATO, Calif., Aug. 22 /PRNewswire-FirstCall/ -- BioMarin Pharmaceutical Inc. (Nasdaq and SWX: BMRN) announced today that it has licensed from the University of California, San Francisco (UCSF) intellectual property covering compounds demonstrated to improve cystic fibrosis transmembrane conductance regulator (CFTR) protein functionality. BioMarin expects the lead compounds to undergo additional animal testing and optimization, with the goal of filing an IND in 2009.

Emil Kakkis, M.D., Ph.D., Chief Medical Officer of BioMarin commented. "Dr. Verkman's laboratory has performed pioneering work in the field of CFTR modulation. The compounds licensed have been developed through a rigorous high-throughput screening process and have demonstrated a high degree of potency and specificity for the folding and activation of the abnormal CFTR protein. We look forward to accelerating the lead optimization activities in collaboration with Dr. Verkman and his colleagues so that we can take the very best of these molecules into clinical development."

"Over the last decade, considerable efforts and funding from the Cystic Fibrosis Foundation and the biotechnology industry have resulted in the development of therapeutics that have significantly extended and improved the lives of cystic fibrosis patients," said Dr. Alan Verkman, Professor of Medicine and Physiology and Director of the Cystic Fibrosis Research Development Program at the University of California, San Francisco. "Despite this progress, there is no therapeutic approved that addresses the underlying molecular defect in cystic fibrosis, and most patients succumb to respiratory failure as young adults. BioMarin has a strong track record of aggressively moving disease modifying therapeutics through clinical development, and I am very pleased that they have made a commitment to fur
'/>"/>

SOURCE BioMarin Pharmaceutical Inc.
Copyright©2007 PR Newswire.
All rights reserved

0

GOOD

Page: 1 2 3 4

Related biology technology :

1. GenTel licenses next generation cancer research
2. Third Wave licenses Innogenetics tech to settle lawsuit
3. WARF licenses patents for new glaucoma drug treatment
4. PKWARE Licenses Technology to Expand SecureZIP Standard
5. Mentor Licenses Botulinum From WARF and Plans Wisconsin Manufacturing Facility
6. Innovative Tissue Array Technology for High-Throughput Screening of Gene Expression
7. HotMasterAn innovative Hot Start/Cold Stop technology for better PCR* results
8. Enhancing Ruggedness and Full-Scan MS Sensitivity Using Ion Sweep Technology
9. Novel MicroRNA Array Technology for Sensitive miRNA Profiling
10. Amplification of genome-representative DNA from limited sources with GenomePlex WGA technology for use in genetic alterations studies
11. Use of FlashPlate Technology for In Vitro Measurement of [35S]-GTPγS Binding in CHO Cells Expressing the Human 5-HT1B Receptor

Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/18/2009)..., Vernier,s experience in data analysis combine...rogram kits and curricula provide state-of..., BEAVERTON, Ore., Nov. 18 Verni...ional science interfaces, sensors, and software an...facturer and distributor of life science research ...
(Date:11/18/2009)..., EAST GRINSTEAD, West Sussex, U.K. and CLEVELAND,...a Magellan Biosciences business and premier provid...ts for microbiology labs, has expanded its East Gr...lopment facility to meet increasing global demand ...bility and identification testing. The expanded fa...
(Date:11/18/2009)... MISSISSAUGA, ON, Nov. 18 /PRNewswire-FirstCall/ -...a life sciences product development company that i...ising cancer-related products at various stages of...evaluating nimotuzumab were presented today in a p... and Cancer Therapeutics conference in Boston, Mas...
(Date:11/18/2009)..., BONITA SPRINGS, Fla., Nov. 18 ...nol® technology, and the technology group T...nt development project in order to identify the op...n (O2) for Algenol,s unique algae and photobioreac...anies join forces to develop cost-efficient techno...
Breaking Biology Technology:Vernier and Bio-Rad to Offer Enhanced Solutions for Biotechnology Education 2TREK Diagnostic Systems Opens New U.K. Facility in East Grinstead to Meet Expanded Customer Demand for Microbiology Products 2TREK Diagnostic Systems Opens New U.K. Facility in East Grinstead to Meet Expanded Customer Demand for Microbiology Products 3TREK Diagnostic Systems Opens New U.K. Facility in East Grinstead to Meet Expanded Customer Demand for Microbiology Products 4YM BIOSCIENCES ANNOUNCES NIMOTUZUMAB RESULTS IN ADVANCED TRIPLE-NEGATIVE BREAST CANCER MODEL PRESENTED AT AACR-NCI-EORTC MEETING 2YM BIOSCIENCES ANNOUNCES NIMOTUZUMAB RESULTS IN ADVANCED TRIPLE-NEGATIVE BREAST CANCER MODEL PRESENTED AT AACR-NCI-EORTC MEETING 3Algenol Biofuels and The Linde Group Agree To Cooperate in CO2 and O2 Management For Biofuel Production From Algae 2Algenol Biofuels and The Linde Group Agree To Cooperate in CO2 and O2 Management For Biofuel Production From Algae 3
... As Fathers Day and commencement ceremonies give w...ns, we turn our attention to that pile of books on...nough time before Labor Day to catch up on our rea...of tech executives what they were reading. I,ve ga...exts and insightful new offerings in this DEMOlet...
... Describes gap between what we know and what we d...delivering information technology for increased pa...by the appeal of cutting-edge technologies, gizmos...d chief operating officer of the University of Wis... Digital Healthcare Conference in Madison produce...
... MADISON I hereby declare the economic downturn i...u say? Well, I guess Im not surprised. But allow m...fore I remind you why youre still a bit skeptical....sconsins economy is back. Consider the following: ...nt in May, down from 5.1 percent in April. Statist...
Other Biology Technology:DEMOletter's Summer Reading List 2DEMOletter's Summer Reading List 3DEMOletter's Summer Reading List 4UW Medical Foundation CEO shares his vision on the state of health care and patient safety 2UW Medical Foundation CEO shares his vision on the state of health care and patient safety 3The economy has come roaring back or is that roar just a purr? 2The economy has come roaring back or is that roar just a purr? 3
(Date:11/20/2009)...009) Scientists from the Marine Biogeochemistry a...search Laboratory (NRL) organized and led a team o...c expedition to initiate methane hydrate explorati...ariation of sediment contribution to Arctic climat...r Polar Sea as a research platform, three cross-sh...
(Date:11/20/2009)... Bacteria possess an ingenious mechanism for preve...he cell. This is the new finding of a team of biol...sciences research institute in Flanders, Belgium, ...cientists made this discovery by modifying the DNA...y means of this model organism, they have uncovere...
(Date:11/20/2009)...dy, researchers report that a class of heart medic... harmful, effect on the heart, depending on their ...n the journal Circulation Research , found that b...receptors on the heart muscle offer the most benef...ly the beta-receptors can actually undermine the s...
Breaking Biology News(10 mins):International expedition investigates climate change, alternative fuels in Arctic 2Biologists discover bacterial defense mechanism against aggressive oxygen 2Carvedilol shown to have unique characteristics among beta blockers 2Study 3A Young Arctic muskoxen better at keeping warm than scientists thought 9642 1Study 3A Young Arctic muskoxen better at keeping warm than scientists thought 9642 2Fattah Advocates D C March for Healthcare By the Supporters of Reform with Public Option 54984 1School Kids Parents Should Get Flu Vaccines First 54981 1School Kids Parents Should Get Flu Vaccines First 54981 2School Kids Parents Should Get Flu Vaccines First 54981 3School Kids Parents Should Get Flu Vaccines First 54981 4
...ins have discovered how cells fine-tune their oxyg...e at the moment. , Too little oxygen threatens lif...hen oxygen is scarce, cells appear to adjust by re...itute that "is specialized to keep the motor runni...says Gregg Semenza, M.D., Ph.D., a professor of pe...
...ally desired most of their potential partners were... a new Northwestern University study. , Conventio...ys to get someone to like you is to make it clear ...d that this law of reciprocity is in dire need of ... , The more you tend to experience romantic desi...
...rees—which trap and absorb carbon dioxide as they ...mosphere. But a new study suggests that, as a way ... strategy depends heavily on where these trees are... efficient at keeping the Earth at a happy, health...ldeira of Carnegie’s Department of Global Ecology ...
Other Biology News:Need oxygen? Cells know how to spend and save 2Selectivity is ultimate aphrodisiac 2Tropical forests -- Earth's air conditioner 2
...fication of GC-rich nucleic acids ,The GC-RICH ...oofreading polymerase, powers through templates th...er polymerases and other blends of polymerases. Th...e GC-RICH Resolution Solution combine to deliver s...
Anti-Taq Monoclonal Antibody, Unconjugated from eEnzyme LLC
Rabbit Anti-B-FABP (FL-132) Polyclonal Antibody, Unconjugated from Santa Cruz Biotechnology, Inc.
Roll of Mesh from Thermo Scientific
Biology Products: