Navigation Links
BioMarin Licenses Technology From Leading Cystic Fibrosis Research Laboratory at the University of California, San Francisco
Date:8/22/2007

Molecular Chaperones Target Underlying Defect in Cystic Fibrosis; CFTR

Folding and Transport

NOVATO, Calif., Aug. 22 /PRNewswire-FirstCall/ -- BioMarin Pharmaceutical Inc. (Nasdaq and SWX: BMRN) announced today that it has licensed from the University of California, San Francisco (UCSF) intellectual property covering compounds demonstrated to improve cystic fibrosis transmembrane conductance regulator (CFTR) protein functionality. BioMarin expects the lead compounds to undergo additional animal testing and optimization, with the goal of filing an IND in 2009.

Emil Kakkis, M.D., Ph.D., Chief Medical Officer of BioMarin commented. "Dr. Verkman's laboratory has performed pioneering work in the field of CFTR modulation. The compounds licensed have been developed through a rigorous high-throughput screening process and have demonstrated a high degree of potency and specificity for the folding and activation of the abnormal CFTR protein. We look forward to accelerating the lead optimization activities in collaboration with Dr. Verkman and his colleagues so that we can take the very best of these molecules into clinical development."

"Over the last decade, considerable efforts and funding from the Cystic Fibrosis Foundation and the biotechnology industry have resulted in the development of therapeutics that have significantly extended and improved the lives of cystic fibrosis patients," said Dr. Alan Verkman, Professor of Medicine and Physiology and Director of the Cystic Fibrosis Research Development Program at the University of California, San Francisco. "Despite this progress, there is no therapeutic approved that addresses the underlying molecular defect in cystic fibrosis, and most patients succumb to respiratory failure as young adults. BioMarin has a strong track record of aggressively moving disease modifying therapeutics through clinical development, and I am very pleased that they have made a commitment to fur
'/>"/>

SOURCE BioMarin Pharmaceutical Inc.
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related biology technology :

1. GenTel licenses next generation cancer research
2. Third Wave licenses Innogenetics tech to settle lawsuit
3. WARF licenses patents for new glaucoma drug treatment
4. PKWARE Licenses Technology to Expand SecureZIP Standard
5. Mentor Licenses Botulinum From WARF and Plans Wisconsin Manufacturing Facility
6. Innovative Tissue Array Technology for High-Throughput Screening of Gene Expression
7. HotMasterAn innovative Hot Start/Cold Stop technology for better PCR* results
8. Enhancing Ruggedness and Full-Scan MS Sensitivity Using Ion Sweep Technology
9. Novel MicroRNA Array Technology for Sensitive miRNA Profiling
10. Amplification of genome-representative DNA from limited sources with GenomePlex WGA technology for use in genetic alterations studies
11. Use of FlashPlate Technology for In Vitro Measurement of [35S]-GTPγS Binding in CHO Cells Expressing the Human 5-HT1B Receptor
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/5/2010)... InfoSpi Inc. (OTC Bulletin Board: ... process of the negotiations to acquire the business ... (IBS). This firm has developed and protected a ... biomass/sludge obtained at sewage treatment plants. ,, IBS ... www.tedagua.com ), a member of the ACS Group ...
(Date:2/5/2010)... Feb. 5 Novavax, Inc. (Nasdaq: ... Dr. Rahul Singhvi , President and Chief Executive ... Annual BIO CEO & Investor Conference on February ... time. Hosted by the Biotechnology Industry Organization (BIO), the ... place February 8-9 at the Waldorf ...
(Date:2/5/2010)... ALTO, Calif. , Feb. 5 /PRNewswire/ ... that Philip Haworth , Ph.D., chief executive officer, will ... Annual BIO CEO & Investor Conference.  The conference will be ... in New York City . ,, Silence,s presentation will ... Monday, February 8, 2010 .  The corporate update provided by ...
(Date:2/4/2010)... A study published today in Science , ... the BBSRC), the Met Office, the Natural Resources ... York, sheds new light on the flight behaviours ... highlights the remarkable abilities of these insect migrants. ... migrating south in autumn to over-wintering sites around ...
Breaking Biology Technology:InfoSpi Shall Benefit From Contract for Future Use of IBS Technology 2NOVAVAX to Present at the 12th Annual BIO CEO & Investor Conference 2Silence Therapeutics to Present at 12th Annual BIO CEO & Investor Conference 2Silence Therapeutics to Present at 12th Annual BIO CEO & Investor Conference 3Migrating insects fly in the fast lane 2
... BOSTON, May 15 Surface Logix today announced that ... his current position,to pursue other interests. Mr. Mahoney will ... future. Steven Gillis,Ph.D., Managing Director at ARCH Venture Partners ... CEO is appointed., "The Board, shareholders and employees ...
... ARAY ), a global leader in the field ... officer, Euan S.,Thomson, Ph.D., is scheduled to present at ... in New York City, on Thursday, May,22, 2008 at ... webcast of the presentation will be available online from ...
... - IND for liquid formulation, NGX-1998, expected to be opened and, ... dermal patch, NGX-4010, in PHN expected in second half ... ... peripheral neuropathic pain, SAN MATEO, Calif., May 15 NeurogesX, Inc.,(Nasdaq: ...
Other Biology Technology:Surface Logix Announces Executive Management Changes 2Accuray Incorporated's CEO to Speak at CitiGroup Healthcare Conference 2NeurogesX Reports First Quarter 2008 Results 2NeurogesX Reports First Quarter 2008 Results 3NeurogesX Reports First Quarter 2008 Results 4NeurogesX Reports First Quarter 2008 Results 5NeurogesX Reports First Quarter 2008 Results 6NeurogesX Reports First Quarter 2008 Results 7
(Date:2/5/2010)... realm of renewable energy could present major obstacles for ... based on carbon resources, according to a report in ... Jack Reardon of the Department of Management & Economics, ... how the transition from carbon to renewable proceeds will ... are listened to in the process. He suggests that ...
(Date:2/5/2010)... , Jan. 26 The ... DigitalPersona, Inc., a leader in fingerprint identity and ... component of Criminal Justice Information System (CJIS) mandates. ... City of Winter Park employs approximately 550 ... City chose DigitalPersona ® Pro and DigitalPersona® ...
(Date:2/5/2010)... - The Wiley Interdisciplinary Reviews (WIREs), the pioneering new ... three of the most prestigious awards in scholarly publishing ... Awards for Professional & Scholarly Excellence (PROSE Awards) named ... Hawkins Award, the association,s top prize, established in 1976 ... the arts and sciences. , The WIREs join ...
Breaking Biology News(10 mins):Renewable oil companies 2City of Winter Park Looks to DigitalPersona Software for Stronger Security and CJIS Compliance 2City of Winter Park Looks to DigitalPersona Software for Stronger Security and CJIS Compliance 3City of Winter Park Looks to DigitalPersona Software for Stronger Security and CJIS Compliance 4WIREs win 3 prizes at the PROSE awards 2Its a gas 3A New discovery may lead to heartier high yielding plants 10847 1Its a gas 3A New discovery may lead to heartier high yielding plants 10847 2Three Month Supply Lowers Drug Costs 61851 1Three Month Supply Lowers Drug Costs 61851 2554 000 in Massachusetts Struggle to Put Food on the Table 61847 1554 000 in Massachusetts Struggle to Put Food on the Table 61847 2554 000 in Massachusetts Struggle to Put Food on the Table 61847 3554 000 in Massachusetts Struggle to Put Food on the Table 61847 4
... of Parkinson,s disease is tremor in patients. A group ... have succeeded in demonstrating the mechanisms which cause the ... brain drive the tremor. This discovery supports Tass, research ... A new deep brain pacemaker is to bring cells ...
... Arlington, VA (July 10, 2008) A third of ... according to the first-ever comprehensive global assessment to determine ... today by Science Express . , Leading ... Assessment (GMSA) a joint initiative of the International ...
... Mass., July 10, 2008 -- Thomas E. Smith, associate ... a $217,710 three-year grant by the National Cancer Institute ... Methods for the Synthesis of Pyran-Based Anticancer Natural Products." ... new methods that will allow for the efficient preparation ...
Other Biology News:'Cross fire' from the brain makes patients tremble 21/3 of reef-building corals face extinction 21/3 of reef-building corals face extinction 31/3 of reef-building corals face extinction 4
... SeeDNA co-precipitant, 250 ul ... color ensures easy pellet ... acid recovery.Chemically inert, compatible ... applications.Simple 5-minute protocol. Category: ...
EDTA, 0.5 M solution, 100 ml. Ethylene diaminetetraacetic acid.Sterile, nuclease-free. Category: Nucleotides & Enzymes & Biochemicals, Ultrapure Biochemicals ....
Recombinant Mouse sTNF RII/TNFRSF1B...
Mouse Wnt-11 Affinity Purified Polyclonal Ab...
Biology Products: