Navigation Links
Bio-hybrid device acts as 'thermostat' to control systemic inflammation in sepsis
Date:5/14/2012

When the bioreactor was loaded with sTNFR-producing cells, sTNFR levels rose beyond what the animal could produce on its own, while TNF-α levels dropped, as did other markers of inflammation. The animal's blood pressure also improved, and markers of organ damage were reduced.

"This bio-hybrid device acts as a kind of inflammation thermostat," Dr. Vodovotz said. "By loading it with cells that produce different amounts of sTNFR, or other inflammatory blockers, we may soon be able to tailor our interventions to carefully balance inflammation and immune responses based on the patient's medical situation."

His team now is exploring the effectiveness of cells engineered to produce sTNFR based on the individual production of TNF-α, rather than continuously, in order to create a disease-specific response for each patient. Such a personalized medicine therapy platform could be extended based on emerging knowledge regarding the biology of inflammation.

The Vodovotz group also is creating computer models of inflammation, which could be used to engineer the next generation of this device. The portability of the device could be particularly useful on the battlefield, where early intervention to control systemic inflammation after injury might improve the chances of survival.


'/>"/>
Contact: Anita Srikameswaran
SrikamAV@upmc.edu
412-578-9193
University of Pittsburgh Schools of the Health Sciences
Source:Eurekalert

Page: 1 2

Related biology technology :

1. BioRestorative Therapies Announces Next Generation of Stem Cell Disc Delivery Device
2. New Revolutionary Femoral Access Site Closure Device Shows Unparalleled Efficacy, Safety & Ease of Use, in a Wide Range of Patients Including Patients With a Challenging Anatomy
3. First successful human results achieved: Implantable wireless microchip drug delivery device
4. Research at Rice University leads to nanotube-based device for communication, security, sensing
5. Powerful AAC Device With IntelĀ® i7 Processor Enables Natural Communication for Stroke, ALS and Autism Patients
6. ResearchMoz: Logic Integrated Circuit (IC) Market to 2020 - Programmable Logic Devices (PLD) and Application Specific Standard Product (ASSP) Dominate with a 78% Market Share
7. New method for enhancing thermal conductivity could cool computer chips, lasers and other devices
8. Low-cost paper-based wireless sensor could help detect explosive devices
9. FDA Establishes New Product Codes for Interbody Devices With Integrated Fixation
10. Drexel expert: Efficiency metrics for energy storage devices need standardization
11. New magnetic-field-sensitive alloy could find use in novel micromechanical devices
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/31/2015)... RATON, Fla. , March 31, 2015  Biotest ... products, is pleased to announce the addition of its ... Drive, Suite 205 Conway, Arkansas . ... its doors for business on March 26 th ... collection centers to eighteen. "This facility ...
(Date:3/31/2015)... FRANCISCO , March 31, 2015  Sonoa Health, ... Australia , has developed a world-first consumer health ... records, medication prescriptions, wearable devices and more. ... Stewart as its CEO, who brings to the ... corporate advisory, which has included working closely with the ...
(Date:3/31/2015)... , March 31, 2015  University of ... Rogers will deliver the plenary session address on ... International Microwave Symposium (IMS) , kicking off a week ... growth at the intersection of RF and microwave technologies ... Assemblies of Radios, Sensors and Circuits for the Skin," ...
(Date:3/30/2015)... Francisco, CA (PRWEB) March 30, 2015 ... tax incentives provided you the government, major companies are ... and local governments setting future mandates for renewable energy ... as an option. , Solara Power is a new ... several incentive programs available that allow qualifying homeowners to ...
Breaking Biology Technology:Biotest Pharmaceuticals Corporation Announces the Opening of its Newest Plasma Collection Facility in Conway, Arkansas 2Investment Banker Appointed CEO of Australian Health Tech Start-Up 2Investment Banker Appointed CEO of Australian Health Tech Start-Up 3Health and Engineering Converge at the 2015 International Microwave Symposium 2Health and Engineering Converge at the 2015 International Microwave Symposium 3Solara Power Announces Residential Solar Power with No Up-Front Fees 2
... System Flexibility & Efficiency, MELVILLE, N.Y., ... ) today announced the launch of NIS-Elements ... confocal and widefield,imaging in a single unifying ... microscopy software enables full integration of confocal,specific ...
... Edwards Lifesciences,Corporation (NYSE: EW ), a global leader ... to announce its operating,results for the quarter ended December ... 2008 and will host a conference call at 5:00 ... participate in the conference call, dial (877) 407-8037 or ...
... Cynosure, Inc.,(Nasdaq: CYNO ), a leading ... aesthetic treatment systems, today announced that the company,will ... call on Tuesday,February 12, 2008 at 9:00 a.m. ... Executive Officer Michael Davin and,Executive Vice President and ...
Cached Biology Technology:Nikon Instruments' New NIS-Elements C Delivers Comprehensive Confocal and Widefield Imaging Capabilities in Single Unifying Software Platform 2Edwards Lifesciences to Host Earnings Conference Call on February 5, 2008 2Cynosure to Announce Fourth-Quarter and Full Year 2007 Financial Results on February 12 2
(Date:3/17/2015)... Minn. , March 17, 2015 ... technology company specializing in clinical study management systems, ... be in attendance at ARENA,s Outsourcing in Clinical ... NC.  This event provides an excellent forum for ... easy-to-use, flexible and affordable software-as-a-service (SaaS) eClinical technology ...
(Date:3/16/2015)... 2015 Between 16 and ... groundbreaking innovations in biometric identification at the CeBIT ...      (Photo: http://photos.prnewswire.com/prnh/20150316/735333 ) ... well at the forefront: the company,s all new ... Germany . BiometricGate is the ...
(Date:3/12/2015)... March 12, 2015 Beta ... identity and access management (IAM) solution for a ... With Beta System,s new IAM package, customers benefit ... gleaned from multiple IAM implementations across different industries. ... as well as any necessary services and consulting. ...
Breaking Biology News(10 mins):Connect With MedNet Solutions At Outsourcing In Clinical Trials Southeast 2DERMALOG Presents its Latest Biometric Innovations at the Hannover CeBIT Exhibition, 16 - 20 March 2015 2DERMALOG Presents its Latest Biometric Innovations at the Hannover CeBIT Exhibition, 16 - 20 March 2015 3Beta Systems Fast Forward IAM Available Now: a Standardized IAM Package at a Fixed Price 2
... ever had trouble sleeping can attest to the difficulties at work ... for ideal health and productivity, but what if five to six ... negatively affected? A team of researchers at Brigham and Women,s ... yourself to be, that lack of sleep can influence the way ...
... People for the Ethical Treatment of Animals (PETA) Foundation ... today alleging that the European Chemicals Agency (ECHA) is ... investigating cases in which animal testing could be avoided ... complaints about maladministration in EU institutions and agencies, and ...
... Mass., July 26, 2012  Aware, Inc. (NASDAQ: AWRE ), ... today reported financial results for its second quarter ended June 30, ... was $5.3 million, a decrease of 10% compared to $5.9 million ... second quarter of 2012 was $369,000 compared to a loss of ...
Cached Biology News:The longer you're awake, the slower you get 2PETA files complaint with European ombudsman over animal testing for REACH 2Aware, Inc. Reports Second Quarter 2012 Financial Results 2Aware, Inc. Reports Second Quarter 2012 Financial Results 3Aware, Inc. Reports Second Quarter 2012 Financial Results 4Aware, Inc. Reports Second Quarter 2012 Financial Results 5Aware, Inc. Reports Second Quarter 2012 Financial Results 6
Prepared from plasminogen by activation with immobilized human uPA...
Human FADD Affinity Purified Polyclonal Ab...
(3-[125I]iodotyrosyl26)Galanin (porcine), 925 kBq, 25 uCi. Category: IODINE LIGANDS....
... quadrupole 1200L sets the new standard ... - incorporating the latest technologies and ... chromatography analytical needs. The Atmospheric ... Transmission Quadrupole Analyzer provide superior selectivity ...
Biology Products: