Navigation Links
Bio-hybrid device acts as 'thermostat' to control systemic inflammation in sepsis
Date:5/14/2012

PITTSBURGH, May 14 - A small, external bioreactor holding human cells pumped out an anti-inflammatory protein to prevent organ damage and other complications in a rat with acute inflammation caused by bacterial products in a model of sepsis, according to a report from researchers at the University of Pittsburgh School of Medicine and the McGowan Institute for Regenerative Medicine. The findings were published today in the inaugural issue of Disruptive Science and Technology.

Inflammation is a necessary biological response that brings cells and proteins to the site of tissue injury to contend with foreign agents, such as bacteria and the products they produce, and to begin the healing process, explained senior author Yoram Vodovotz, Ph.D., professor, Department of Surgery, and director, Center for Inflammation and Regenerative Modeling at the McGowan Institute. But sometimes, the inflammatory response escalates to create damage on its own, triggering more inflammation in a self-sustaining and dangerous cycle.

"In sepsis, for example, the inflammatory response evolves almost too quickly, but the available treatment strategies aim to prevent inflammation entirely," he said. "A better approach would be to turn down the response when it's too strong, yet still have appropriate inflammation signaling to promote tissue repair."

During inflammation, the body makes a protein called tumor necrosis factor-alpha, or TNF-α. It also makes its counterpart, soluble TNF-α receptor, or sTNFR, which binds to and reduces the level of TNF-α. In some situations, such as sepsis, not enough sTNFR is made to limit the inflammatory response.

Dr. Vodovotz and his team loaded a small bioreactor with human liver cells engineered to make sTNFR continuously. Through an intravenous line, blood from an anesthetized rat experiencing acute but transient inflammation was pumped through the bioreactor, exposing it to the engineered cells.
'/>"/>

Contact: Anita Srikameswaran
SrikamAV@upmc.edu
412-578-9193
University of Pittsburgh Schools of the Health Sciences
Source:Eurekalert

Page: 1 2

Related biology technology :

1. BioRestorative Therapies Announces Next Generation of Stem Cell Disc Delivery Device
2. New Revolutionary Femoral Access Site Closure Device Shows Unparalleled Efficacy, Safety & Ease of Use, in a Wide Range of Patients Including Patients With a Challenging Anatomy
3. First successful human results achieved: Implantable wireless microchip drug delivery device
4. Research at Rice University leads to nanotube-based device for communication, security, sensing
5. Powerful AAC Device With Intel® i7 Processor Enables Natural Communication for Stroke, ALS and Autism Patients
6. ResearchMoz: Logic Integrated Circuit (IC) Market to 2020 - Programmable Logic Devices (PLD) and Application Specific Standard Product (ASSP) Dominate with a 78% Market Share
7. New method for enhancing thermal conductivity could cool computer chips, lasers and other devices
8. Low-cost paper-based wireless sensor could help detect explosive devices
9. FDA Establishes New Product Codes for Interbody Devices With Integrated Fixation
10. Drexel expert: Efficiency metrics for energy storage devices need standardization
11. New magnetic-field-sensitive alloy could find use in novel micromechanical devices
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/1/2015)... 2015 Pfenex Inc. (NYSE MKT: PFNX), ... of biosimilar therapeutics including high value and difficult ... quarter 2015 financial results will be released on ... market. At 8:30 am Eastern Time, Pfenex management will ... results and provide a business update. A press release ...
(Date:5/1/2015)... -- According to a new market ... by Type (Monoclonal, Polyclonal), by Technology (Hybridoma), by ... Analysis & Global Forecast to 2019", published by ... Market for the forecast period of 2014 to ... Billion by 2019 from $1.425 Billion in 2014, ...
(Date:4/30/2015)... Cytokinetics, Incorporated (Nasdaq: CYTK) reported total research ... $4.4 million, compared to $8.0 million during the same period ... was $8.9 million, or $0.23 per basic and diluted share. ... period in 2014, of $8.7 million, or $0.27 per basic ... cash equivalents and investments totaled $117.5 million. , "During ...
(Date:4/30/2015)... Cambridge, MA & Budapest, Hungary (PRWEB) April 30, ... the only web-based electronic lab notebook with integrated ... leader in providing chemistry software solutions and consulting ... that led to the development of Labguru’s newest ... a set of deep domain features for biologists, ...
Breaking Biology Technology:Pfenex To Report First Quarter 2015 Results and Provide Business Update on Thursday, May 14, 2015 2Antibody Production Market worth $2.572 Billion by 2019 2Antibody Production Market worth $2.572 Billion by 2019 3Antibody Production Market worth $2.572 Billion by 2019 4Cytokinetics, Incorporated Reports First Quarter 2015 Financial Results 2Cytokinetics, Incorporated Reports First Quarter 2015 Financial Results 3Cytokinetics, Incorporated Reports First Quarter 2015 Financial Results 4Cytokinetics, Incorporated Reports First Quarter 2015 Financial Results 5Cytokinetics, Incorporated Reports First Quarter 2015 Financial Results 6Cytokinetics, Incorporated Reports First Quarter 2015 Financial Results 7Cytokinetics, Incorporated Reports First Quarter 2015 Financial Results 8Labguru Integrates ChemAxon's Marvin JS, to Enhance Functionality for Chemists 2
... The New Jersey Board of,Pharmacy has ... pharmacy,technicians at Wedgewood Pharmacy. The program was ... Affairs Department. Upon,completion of the program, each ... high level of competence in all state ...
... ORLANDO, Fla., Sept. 7 Daniel B. Yarosh, ... keynote presentation at the 11th,Annual Sunscreen Symposium today ... 6th-9th) of cosmetic chemists is sponsored by the,Florida ... Yarosh will,present "Beyond Sunscreens: DNA Repair and Photoaging" ...
... Genmab Announces ofatumumab Appeared More Effective Than rituximab ... ... Genmab A/S,(OMX: GEN) announced today that ofatumumab (HuMax-CD20(R)) appeared ... mechanism, than rituximab in a pre-clinical study. The CD20,antibodies were ...
Cached Biology Technology:NJ Board of Pharmacy Approves Wedgewood Pharmacy Technician-Training Program 2NJ Board of Pharmacy Approves Wedgewood Pharmacy Technician-Training Program 3AGI Dermatics President to be Keynote Speaker at the 11th Annual Sunscreen Symposium 2Genmab Announces Encouraging Preclinical Data for ofatumumab 2
(Date:4/14/2015)... April 14, 2015 NXT-ID, Inc. (NASDAQ: ... company focused on the growing mobile commerce market, announces ... the 2015 New York Design Awards under the category  ... York City Design Awards are part of a global ... 2,500 ratings from the marketplace, industry and judging panel. ...
(Date:4/10/2015)... April 10, 2015 Research and ... the "Security Competitive Profiles - NEC" report ... NEC will continue to supply a range ... market, with a company focus on the development of ... Winning opportunities in the Asia-Pacific ...
(Date:4/6/2015)... 6, 2015 NXT-ID, Inc. (NASDAQ: NXTD ... company focused on the growing mobile commerce market, ... 62/143028 for MINIATURE, MULTI-PURPOSE ANTENNA METHOD AND ... NXT-ID introduces a new revolutionary method and ... the use of miniature antenna modules for multiple ...
Breaking Biology News(10 mins):NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 2NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 3NEC Security Competitive Profile 2015 2NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 2NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 3NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 4
... Medicine researchers have discovered how new neurons born from ... the brain where they can replace old and dying ... can be specifically targeted to brain regions affected by ... Zhou and graduate student Kwan L. Ng in the ...
... last year at Petrified Forest National Park in Arizona throws ... arose more than 210 million years ago at the end ... creatures from the Late Triassic known only from their teeth, ... dinosaurs like Stegosaurus and Triceratops, which roamed the world millions ...
... science gets wiser, so do the bugs. The rates ... in the hospital have been increasing steadily in recent ... 15 issue of Clinical Infectious Diseases, now available online. ... due in part to inappropriate prescribing and overuse of ...
Cached Biology News:Researchers discover stem cell 'guide' that may be key for targeting neural stem cell treatments 2Agilent Technologies introduces high-capacity human protein removal system for proteomics research 2Agilent Technologies introduces high-capacity human protein removal system for proteomics research 3Agilent Technologies introduces high-capacity human protein removal system for proteomics research 4Two studies document rise of superbugs in the environment 2Two studies document rise of superbugs in the environment 3
... liter of urine will give a positive reaction ... ,Certification: The Donors are of US origin ... NEGATIVE for HbsAg, HCV, HIV-1 & 2, Syphilis ... THIS MATERIAL IS SOLD FOR IN-VITRO DIAGNOSTIC USE ...
... Identical to the DH-2000, except that it ... 190-1700 nm wavelength range and comes with a ... up to 5 Hz) The DH-2000 ... spectrum of deuterium and tungsten halogen light sources ...
... pump is a dedicated cuff pump for small ... replaces manual inflation and can be used for ... mouse and rat; from single up to multi-channel ... pump has adjustable cut-off pressure in 50 mmHg ...
... These handy dispensers save space ... hats, and other garb. They are ... small parts used in labs, processing ... static charges and the particles they ...
Biology Products: