Navigation Links
Bio-hybrid device acts as 'thermostat' to control systemic inflammation in sepsis
Date:5/14/2012

PITTSBURGH, May 14 - A small, external bioreactor holding human cells pumped out an anti-inflammatory protein to prevent organ damage and other complications in a rat with acute inflammation caused by bacterial products in a model of sepsis, according to a report from researchers at the University of Pittsburgh School of Medicine and the McGowan Institute for Regenerative Medicine. The findings were published today in the inaugural issue of Disruptive Science and Technology.

Inflammation is a necessary biological response that brings cells and proteins to the site of tissue injury to contend with foreign agents, such as bacteria and the products they produce, and to begin the healing process, explained senior author Yoram Vodovotz, Ph.D., professor, Department of Surgery, and director, Center for Inflammation and Regenerative Modeling at the McGowan Institute. But sometimes, the inflammatory response escalates to create damage on its own, triggering more inflammation in a self-sustaining and dangerous cycle.

"In sepsis, for example, the inflammatory response evolves almost too quickly, but the available treatment strategies aim to prevent inflammation entirely," he said. "A better approach would be to turn down the response when it's too strong, yet still have appropriate inflammation signaling to promote tissue repair."

During inflammation, the body makes a protein called tumor necrosis factor-alpha, or TNF-α. It also makes its counterpart, soluble TNF-α receptor, or sTNFR, which binds to and reduces the level of TNF-α. In some situations, such as sepsis, not enough sTNFR is made to limit the inflammatory response.

Dr. Vodovotz and his team loaded a small bioreactor with human liver cells engineered to make sTNFR continuously. Through an intravenous line, blood from an anesthetized rat experiencing acute but transient inflammation was pumped through the bioreactor, exposing it to the engineered cells.
'/>"/>

Contact: Anita Srikameswaran
SrikamAV@upmc.edu
412-578-9193
University of Pittsburgh Schools of the Health Sciences
Source:Eurekalert

Page: 1 2

Related biology technology :

1. BioRestorative Therapies Announces Next Generation of Stem Cell Disc Delivery Device
2. New Revolutionary Femoral Access Site Closure Device Shows Unparalleled Efficacy, Safety & Ease of Use, in a Wide Range of Patients Including Patients With a Challenging Anatomy
3. First successful human results achieved: Implantable wireless microchip drug delivery device
4. Research at Rice University leads to nanotube-based device for communication, security, sensing
5. Powerful AAC Device With Intel® i7 Processor Enables Natural Communication for Stroke, ALS and Autism Patients
6. ResearchMoz: Logic Integrated Circuit (IC) Market to 2020 - Programmable Logic Devices (PLD) and Application Specific Standard Product (ASSP) Dominate with a 78% Market Share
7. New method for enhancing thermal conductivity could cool computer chips, lasers and other devices
8. Low-cost paper-based wireless sensor could help detect explosive devices
9. FDA Establishes New Product Codes for Interbody Devices With Integrated Fixation
10. Drexel expert: Efficiency metrics for energy storage devices need standardization
11. New magnetic-field-sensitive alloy could find use in novel micromechanical devices
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... HONG KONG , Aug. 21, 2014  China Cord ... today announced its plan to release financial results for ... August 28, 2014, after market close in the US.  ... call at 8:00 a.m. ET on Friday, August 29, ... brief overview of the Company,s recent developments, followed by ...
(Date:8/21/2014)... Ontotext S4 , The Self Service Semantic ... Now the same enterprise hardened text mining, Linked Data ... is available to start-ups and mid-size businesses at a ... do not have resources to evaluate and prototype enterprise ... there is no need for on premise hardware provisioning ...
(Date:8/21/2014)... On Wednesday of last week RENU 28, the ... molecules, became available for purchase in Australia and New Zealand, ... RENU 28 works is, if you think about the definition ... of cellular renewal within your body. If you think about ... of cellular renewal. What RENU 28 does is it works ...
(Date:8/20/2014)... that American Indians largely were wiped out by diseases ... brought to the New World by European explorers., One ... lived in the Americas shortly before Europeans arrived, and ... diseases., But new research led by anthropological geneticists Anne ... the University of Tubingen in Germany indicates the diagnosis ...
Breaking Biology Technology:China Cord Blood Corporation to Report First Quarter of Fiscal 2015 Financial Results 2Ontotext Releases Text Mining & Semantic Technology Running in the Cloud – Welcome to “S4? 2Ontotext Releases Text Mining & Semantic Technology Running in the Cloud – Welcome to “S4? 3Ontotext Releases Text Mining & Semantic Technology Running in the Cloud – Welcome to “S4? 4RENU 28 Skin Care Now Available in Australia and New Zealand 2Unusual discovery leads to fascinating tuberculosis theory 2Unusual discovery leads to fascinating tuberculosis theory 3
... WEST BRIDGEWATER, Mass., Aug. 30 Pressure,BioSciences, ... announced that it has been,issued its first ... "Pressure-Mediated Binding of Biomolecular Complexes" (Number,2,259,318), this ... pressure,cycling technology (PCT) patents previously issued in ...
... ITMN ) today announced that Daniel G. Welch, ... the Thomas Weisel,Healthcare Conference in Boston on September 5, ... at the Bear Stearns 20th Annual Healthcare,Conference in New ... EDT. To access a live audio webcast of ...
... 30 VaxGen,Inc. (Pink Sheets: VXGN) announced today ... Commission (SEC) its Annual Report on Form 10-K ... Reports on Form 10-Q for the,first three quarters ... the link titled,"SEC Filings" in the Investor Relations ...
Cached Biology Technology:Pressure BioSciences, Inc. Issued First Patent in Canada 2Pressure BioSciences, Inc. Issued First Patent in Canada 3InterMune to Present at Thomas Weisel and Bear Stearns Healthcare Conferences 2VaxGen Files 2006 Financial Statements and Provides Cash Update 2
(Date:8/21/2014)... linked to dandruff, eczema and other itchy, flaky maladies ... global reachesincluding Hawaiian coral reefs and the extreme environments ... review in the scientific journal PLOS Pathogens ... of the genus Malassezia in light of ... around the world. , University of Hawai,i at Mānoa ...
(Date:8/21/2014)... Juliane Mller the Fram Strait is a key region in ... passage between Greenland and Svalbard warm Atlantic water flows to ... side cold Arctic water masses and sea ice push their ... considerable portion of the Atlantic water cools here on its ... circulation of the water caused in this manner drives the ...
(Date:8/21/2014)... RUSTON, La. A team of researchers ... innovative method for using affordable, consumer-grade 3D ... implants that can contain antibacterial and chemotherapeutic ... team comprised of doctoral students and research ... nanosystems engineering programs collaborated to create filament ...
Breaking Biology News(10 mins):From dandruff to deep sea vents, an ecologically hyper-diverse fungus 2Arctic sea ice influenced force of the Gulf Stream 2Arctic sea ice influenced force of the Gulf Stream 3Louisiana Tech University researchers use 3D printers to create custom medical implants 2Louisiana Tech University researchers use 3D printers to create custom medical implants 3
... builder. Using a bottom-up approach, nature takes tiny atoms ... silicon and even table salt. In all of them, ... and arrangement of atoms within the crystalline lattice. ... learned how to top nature by building crystalline materials ...
... ARLINGTON, Va.R&D Magazine honored Office of Naval Research ... "R&D 100" award on Oct. 13 for the development ... The special high-tech surface technology, HybridSil Fire/Blast, acts ... type of surface, making it blast-, ballistic- and fire-resistant. ...
... 2011 Researchers have shown for the first time that ... in cats. The research was conducted at the WALTHAM Centre ... such as WHISKAS and ROYAL CANIN. The research demonstrated ... daily water intake to a level that cannot be achieved ...
Cached Biology News:Emulating -- and surpassing -- nature 2Emulating -- and surpassing -- nature 3Spray-on protective coating wins 'R&D 100' Award 2
Request Info...
...
Mouse GM CSF Construction Kit provides antigen affinity purified polyclonal capture and tracer antibodies, and antigen standard for development of approximately ten microplate assays....
... Upright Freezer Inventory Storage Racks ... configurations available to fit all makes ... refrigerators. Made of high quality ... 3" high fiberboard, stainless steel or ...
Biology Products: