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Berg Launches First-Ever Stratified Medicine Clinical Trial To Investigate Cancer Metabolism Of Solid Tumors
Date:11/21/2013

network biology methodologies to study biological systems.

Through Berg's proprietary Interrogative Biology™ Drug Discovery Platform, this clinical program will establish each patient's molecular and metabolic fingerprint by analyzing multi-omic tissue samples (blood, urine, bone marrow, etc) in real time. This step will allow trial investigators to understand how patients' cells are responding to the treatment to assess the unique characteristics in patients who are responding to the therapy or combinations with BPM 31510.  One very interesting arm of the trial will also assess the effect of "mitochondrial priming" where BPM 31510 will be given for 1 cycle followed by chemotherapy to assess for increased efficacy and potential reduction in chemo-induced side effects.

"It is both a privilege and honor to work with Berg - a forward thinking broad reaching company that is interested in truly moving the bar in medicine in a comprehensive and revolutionary way," said Dr. Manish A. Shah, Associate Professor of Medicine at the Weill Cornell Medical College of Cornell University.  "The goal of this comprehensive and unprecedented evaluation of clinical data, molecular profiles, and patient characteristics - a virtual clinical 'big data' evaluation - is to develop safer, more effective drugs in half the time. Drug development is an arduous process, but with Berg as a partner, it feels like we are on the fast track."

More information about the clinical trials evaluating BPM 31510 also can be found at www.ClinicalTrials.gov.

About BPM 31510
Berg's lead molecular candidate, BPM 31510, is a proprietary formulation of ubidecarenone, an endogenous small molecule responsible for generating cell energy. Preclinical trials indicate that BPM 31510 normalizes the BCL2 protein, which is a key feature in the regulation of cell death and is over-expressed in 60-70% o
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