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BellBrook Labs Launches New Turn Key Methyltransferase Assay Kit for Oncogenic Histone Methyltransferase EZH2
Date:8/28/2013

r inhibitor screening and profiling with purified methyltransferases enzymes.

EZH2 is a complex of five different proteins that act in concert to catalyze mono-, di- and tri-methylation of Histone 3 at Lys 27. The tri-methyl H3K27 mark causes transcriptional silencing of several tumor suppressors, and overexpression, amplification and somatic mutations have all been identified as mechanisms for the involvement of EZH2 in tumorigenesis. The new Transzyme EZH2 Assay kit is designed to accelerate efforts to develop selective EZH2 inhibitors using high throughput screening of small molecule libraries. The kit includes purified EZH2 from Reaction Biology, Histone H3 substrate, optimized buffer and the Transcreener EPIGEN Methyltransferase Assay reagents in a turn-key kit that has been pre-calibrated to produce HTS-quality assay windows.

About BellBrook Labs. BellBrook Labs is dedicated to accelerating drug discovery and biological research by providing innovative high throughput screening solutions for enzymes and phenotypic assays. The company’s Transcreener® HTS enzyme assays, used by all of the major pharmaceutical companies, make it easy to screen thousands of different enzymes, including validated targets like kinases, as well as emerging targets like ATPases, GTPases, methyltransferases, and glycosyltransferases. The iuvo™ Microconduit Array technology and assay screening service are based on a line of unique microscale devices for miniaturization and automation of advanced cell models that are more representative of human physiology.

About Reaction Biology. Reaction Biology Corporation (“RBC”) is a premier provider of in vitro enzyme activity assays for HTS and profiling. Serving over 200 customers worldwide, RBC specializes in optimizing nanoliter scale assaying methods, allowing for high quality data with fast turnaround and economical pricing. RBC offers gold-standard radioisotope based assays in the Kinase, Methyltransferas
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