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BellBrook Labs Launches New Turn Key Methyltransferase Assay Kit for Oncogenic Histone Methyltransferase EZH2
Date:8/28/2013

Madison, WI (PRWEB) August 28, 2013

BellBrook Labs is continuing their successful collaboration with Reaction Biology to accelerate epigenetics drug discovery with the launch of a new Transzyme Methyltransferase Assay kit for histone methyltransferase EZH2. The Transzyme EZH2 kit combines all of the required EZH2 enzyme reaction components and BellBrook’s Transcreener EPIGEN Methyltransferase Assay detection reagents into a well-defined kit that is pre-calibrated to produce HTS-quality data. With the addition of EZH2, the expanding line of Transzyme Methyltransferase Assays now numbers fourteen, including DOT1L, G9a, MLL4, PRMT1, PRMT3 SET7/9, SET8, SUVH391 and DNMT1. By eliminating the need for sourcing and testing of reagents from different vendors and trouble-shooting to optimize assay performance, the new Transzyme kits should accelerate the pursuit of promising epigenetic therapeutic strategies for cancer and other diseases.

Methyltransferases are key players in epigenetic control of gene expression and have become the targets of intensive public and private drug discovery efforts. Unfortunately, the first step in developing epigenetic drugs – identification of specific inhibitors for target enzymes – has been plagued by problems in getting methyltransferase enzymes to function correctly in the HTS assays used to detect their activity. To eliminate this hurdle, BellBrook Labs and Reaction Biology partnered last year to develop the Transzyme Methyltransferase Assay kits as complete solutions fo
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