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BellBrook Labs Launches Compound Profiling Services with High Content 3D Invasion Assay
Date:5/5/2010

The 3D ECM Invasion Assay service combines BellBrook’s proprietary iuvo™ Microconduit Array platform and automated high content analysis to produce images of tumor cells actively invading the extracellular matrix. The company can provide customers with quantitative measurements of the anti-invasive properties of their compounds based on true 3D cell migration with sufficient throughput for profiling hundreds of compounds.

Madison WI (PRWEB) May 5, 2010 -- BellBrook Labs announced at the 2010 Society for Biomolecular Screening Symposium the launch of a new invasion assay service for profiling the effects of potential drug molecules on migration of tumor cells through extracellular matrix. The assay was developed as a more physiologically relevant and information-rich alternative to commonly used filter-based assays. The assays are run in submicroliter channels in BellBrook's recently developed iuvo Microchannel 5250 plates. Cells are added to the liquid media compartment and allowed to migrate into the collagen-filled microchannels. Automated microscopy and proprietary algorithms are then used to image the ultrathin assay compartments, generating quantitative data on number of cells invading the matrix and distance traveled as well as effects on cell proliferation. MC5250 plates have 192 channels in an SBS/ANSI format and the assay is fully automated, so throughput is sufficient for secondary screening and data quality is high enough for quantitative IC50 determinations. Th
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