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Baylor College of Medicine and Gradalis Enter Collaboration Agreement to Utilize Gradalis' Bifunctional shRNA Platform in Translational Medicine Research
Date:7/11/2012

DALLAS, July 11, 2012 /PRNewswire/ -- Today Baylor College of Medicine (BCM) and Gradalis, Inc. announced the signing of a Master Collaboration Agreement focused on BCM scientists' use of Gradalis' proprietary bifunctional shRNA (bi-shRNA) platform in BCM's research directed at various biological targets for therapeutic intervention.  The translational medicine collaboration covers multiple BCM investigators and multiple therapeutic targets in cancer.

This collaboration will further BCM's mission of advancing human health through the integration of education, research, patient care and community service. Gradalis will benefit from the collaboration because BCM researchers will conduct early-stage research needed for proof of concept and formal pre-clinical studies, manufacturing, quality assurance and quality control, supporting assay development, regulatory submissions and clinical development.

"Agreements with commercial partners like Gradalis will help BCM accelerate the development of promising therapeutic approaches and links our strengths in discovery phase research with Gradalis' clinical development capabilities,"  said Adam Kuspa, Ph.D., Vice President for Research for BCM. "We look forward to a very fruitful research and development relationship."

As part of the collaboration, Gradalis will share with the scientists at BCM the company's novel bi-shRNA constructs that shut down expression of specific proteins of therapeutic interest. Gradalis will also provide BCM researchers access to its portfolio of proprietary research-enabling technologies including SuperClean DNA, reversible masking, liposomal delivery and liposomal targeting. Those bi-shRNA constructs showing promise in pre-clinical testing at BCM will be moved forward into clinical development by Gradalis.

"We look forward to entering into the collaborative development of a new line of therapeutic molecules that have not been exploited previously," said
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SOURCE Gradalis, Inc.
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