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Baxter and Halozyme Announce Collaboration for Development of Subcutaneous GAMMAGARD LIQUID(TM) Administration Using Enhanze(TM) Technology
Date:9/10/2007

ter's GAMMAGARD LIQUID 10% is a large molecule therapy made from human plasma that is indicated for the treatment of primary immunodeficiency disorders associated with defects in immune system. Enhanze Technology is Halozyme's proprietary drug delivery technology based on rHuPH20. rHuPH20 is a form of human enzyme that temporarily clears space in the matrix of tissues underlying the two outer layers of the skin to increase absorption and spreading of injected drugs.

"By using Enhanze Technology to facilitate a subcutaneous route of administration for GAMMAGARD LIQUID, patients with immunodeficiency disorders could benefit from access to home therapy that may potentially allow full IV dosing with the convenience of subcutaneous delivery," said Hartmut J. Ehrlich, MD, vice president of global research and development for Baxter's BioScience business. "This partnership represents Baxter's ongoing scientific innovation and investment in enhancing administration of GAMMAGARD LIQUID therapy."

"We believe our technology can enhance the clinical benefits that biologics have already been shown to provide. We are very excited to expand our relationship with Baxter so that they may make this important product available to as many people as possible worldwide as a way to simplify the delivery of medications and fluids and, ultimately, provide a more comfortable patient experience," said Jonathan Lim, MD, president and CEO of Halozyme.

In February 2007, Baxter and Halozyme expanded their ongoing collaboration to commercialize product combinations of HYLENEX(TM) recombinant (hyaluronidase human injection) with certain Baxter proprietary and non- proprietary small molecule therapies. HYLENEX is a formulation of rHuPH20, supplied by Halozyme, indicated to facilitate the absorption and dispersion of other injected drugs or fluids. HYLENEX is manufactured by Baxter Healthcare Corporation for Halozyme.

About Enhanze(TM) Technology

Enhanze Technology is Ha
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SOURCE Baxter International Inc.
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