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Baxter Adds Recombinant Protein to Specialty Therapeutics Portfolio
Date:10/16/2007

ding. Platelet adherence is mediated by naturally occurring von Willebrand factor (VWF), a large protein found in the circulating blood, and naturally occurring ADAMTS13, an enzyme that plays a critical role in hemostasis by actively regulating the function of VWF.

Under the terms of this agreement, Kaketsuken will provide Baxter with access to Kaketsuken's intellectual property rights concerning the recombinant protein. Baxter has an exclusive license to the recombinant ADAMTS13 intellectual property rights worldwide, except for Japan where Baxter has a co-exclusive license to commercialize recombinant ADAMTS13 with Kaketsuken. In addition to an upfront payment upon signing the agreement, Baxter will pay Kaketsuken milestone payments upon Investigational New Drug (IND) filing, initiation of Phase II and Phase III trials, Biologics License Application (BLA) filings and US Food and Drug Administration approval of recombinant ADAMTS13.

The inclusion of ADAMTS13 in Baxter's pre-clinical portfolio fits into the company's platform of specialty pharmaceuticals. Baxter has pioneered protein therapies developed from the separation and purification of important blood components and recombinant technologies, applying its knowledge and resources to become a leader in blood-related disorders such as hemophilia and other immune deficiencies. Baxter is recognized as a global leader in hemophilia therapies with a growing portfolio of innovative therapies and technologies, developed through strategic collaborations and internal research and development.

About TTP

TTP is a thrombotic disorder that is caused by the formation of platelet- rich thrombi in blood vessels throughout the body. Hereditary TTP, also known as Upshaw Schulman syndrome, is caused by detrimental mutations of the ADAMTS13 gene, resulting in severe ADAMTS13 deficiency, whereas acquired TTP is often due to auto-antibodies directed against ADAMTS13. Characterized by bruising, anemia, fever, n
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SOURCE Baxter International Inc.
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