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Barrow TRPV1 research highlighted in Journal of Neuroscience
Date:2/2/2011

ain to suppress locomotion.

"We all know that the body's propensity for physical activity changes based on numerous factors," explains Dr. Romanovsky. "For example, we do not want to exercise after having a large meal, when it is hot outside, or when we are tired, nauseated or in pain. We all know people who seem to be naturally inactive, as well as people who are more active than others. Our study suggests that the TRPV1 receptors may send signals that play a role in regulating the extent of locomotor activity."

This discovery, which is part of St. Joseph's trauma research, could have wide implications in determining whether TRPV1 receptors are involved in any of several motor and behavioral disorders, as well as the regulation of body weight. Future studies could potentially look at whether TRPV1-activating drugs could be used to decrease the propensity for exercise when people are confined to a limited space for prolonged time periods, as during spaceflight missions, or whether TRPV1-suppressing drugs could be used to boost levels of physical performance and endurance.


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Contact: Lynne Reaves
lynne.reaves@chw.edu
602-406-4734
St. Joseph's Hospital and Medical Center
Source:Eurekalert

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