Navigation Links
Barrow TRPV1 research highlighted in Journal of Neuroscience
Date:2/2/2011

(Phoenix, Arizona February 1, 2011) -- Research by a Barrow Neurological Institute scientist on the thermoregulatory effects of a receptor more commonly studied for its role in pain is the cover story in the Feb. 2 issue of the Journal of Neuroscience. The research was conducted by an international team led by Andrej Romanovsky, MD, PhD, Director of the Systemic Inflammation Laboratory (FeverLab), at Barrow, which is a part of St. Joseph's Hospital and Medical Center.

The featured research discovers a new role of TRPV1 (transient receptor potential vanilloid-1) receptors in the regulation of locomotor activity, or the movement from place to place. These receptors are widely known for their ability to be activated by capsaicin, the compound responsible for the hotness in chili peppers. TRPV1 receptors are located on sensory neural cells throughout the body and can also be activated by high temperature, acidity and other stimuli. Because of their responsiveness to such diverse factors, TRPV1 receptors are thought to serve as sensory integrators of the body's internal and external environments.

The study by Dr. Romanovsky's team was conducted in mice genetically deficient in the TRPV1 receptor. While studying how TRPV1-deficient mice regulate their body temperature, the researchers made an unexpected observation that these animals, when young, exhibit a much higher locomotor activity than control mice. Even during the light phase of the day (when mice are typically inactive), TRPV1-deficient animals were moving in the experimental chamber with an average speed of nearly one yard per minute faster than the speed of control mice at the peak of their daily activity.

The researchers then conducted experiments with drugs that block or activate TRPV1 receptors and looked at how these drugs affect general motor activity. These pharmacological experiments confirmed that TRPV1 receptors located outside the brain send signals to the brain to suppress locomotion.

"We all know that the body's propensity for physical activity changes based on numerous factors," explains Dr. Romanovsky. "For example, we do not want to exercise after having a large meal, when it is hot outside, or when we are tired, nauseated or in pain. We all know people who seem to be naturally inactive, as well as people who are more active than others. Our study suggests that the TRPV1 receptors may send signals that play a role in regulating the extent of locomotor activity."

This discovery, which is part of St. Joseph's trauma research, could have wide implications in determining whether TRPV1 receptors are involved in any of several motor and behavioral disorders, as well as the regulation of body weight. Future studies could potentially look at whether TRPV1-activating drugs could be used to decrease the propensity for exercise when people are confined to a limited space for prolonged time periods, as during spaceflight missions, or whether TRPV1-suppressing drugs could be used to boost levels of physical performance and endurance.


'/>"/>

Contact: Lynne Reaves
lynne.reaves@chw.edu
602-406-4734
St. Joseph's Hospital and Medical Center
Source:Eurekalert

Related biology technology :

1. Shareholder Class Action Filed Against Elan Corporation, plc by the Law Firm of Barroway Topaz Kessler Meltzer & Check, LLP
2. Size of airborne flu virus impacts risk, Virginia Tech researchers say
3. What a ride! Researchers take molecules for a spin
4. Dr. Stefan Strauf of physics at Stevens receives NSF CAREER Award for quantum research
5. Research 2.0 Initiates Coverage of Viral Genetics and Publishes Research Report
6. Department of Energy Funds SRI to Enhance Bioinformatics Tools for Renewable Energy Research
7. Practice Fusion Invites Health Researchers to Analyze This! Contest on Windows Azure
8. Cellectis bioresearch First to Launch Revolutionary Custom TAL Nuclease Service
9. Columbia University researchers use nanoscale transistors to study single-molecule interactions
10. Role of Market Research Evolving to Take on a More Strategic Responsibility
11. Leading Dental Stem Cell and Regenerative Medicine Researcher Dr. George Huang Joins StemSaves Science Advisory Council
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/29/2016)... ... April 29, 2016 , ... Amendia, Inc., ... surgical procedures, today announced the completion of a significant transaction and partnership that ... future customers and partners. Kohlberg & Company, L.L.C. (“Kohlberg”), a leading private ...
(Date:4/29/2016)... ... April 29, 2016 , ... Summit for Stem Cell has received a ... a patient-specific stem cell therapy for the treatment of Parkinson’s disease. The Summit research ... at The Scripps Research Institute in San Diego, CA. , The aim ...
(Date:4/28/2016)... PUNE, India , April 28, 2016 ... PT, JT, Stirling, and Brayton Cryocoolers), Service (Technical Support, ... Application, and Geography - Global Forecast to 2022", published ... to USD 2.94 Billion by 2022, at a CAGR ... Browse 70 market data Tables and 94 Figures spread ...
(Date:4/28/2016)... Boston, MA (PRWEB) , ... April 28, 2016 ... ... (EDT), Asymmetrex will deliver a talk on its first-in-class technologies for ... the 2016 Meeting on RNAiMicroRNA Biology to Reprogramming & CRISPR-based Genome ...
Breaking Biology Technology:
(Date:3/11/2016)... http://www.apimages.com ) - --> http://www.apimages.com ... at AP Images ( http://www.apimages.com ) - Germany ... produce the new refugee identity cards. DERMALOG will be unveiling this ... Hanover next week.   --> ... to produce the new refugee identity cards. DERMALOG will be unveiling ...
(Date:3/9/2016)... This BCC Research report provides an overview ... Sequencing (RNA Seq) market for the years 2015, 2016 ... reagents, data analysis, and services. Use this ... market such as RNA-Sequencing tools and reagents, RNA-Sequencing data ... each segment and forecast their market growth, future trends ...
(Date:3/3/2016)... , March 3, 2016  FlexTech, a SEMI ... categories of Innovation, Research & Development, Leadership in Education, ... This is the 9 th year of the ... of companies and individuals from past years . ... on a pre-described set of criteria, by a panel ...
Breaking Biology News(10 mins):