Navigation Links
Bacterial resistance to antibiotics: The more they resist, the more they divide
Date:7/29/2011

The number of multiresistant strains of bacteria in hospitals is increasing. Bacteria acquire resistance to antibiotics through mutations in their chromosomes and by incorporating new genes, either from the surrounding environment or from other bacteria. Now, a research team at the Portuguese CBA research (University of Lisbon) and the Instituto Gulbenkian de Cincia has shown that, surprisingly, when both mechanisms of resistance are playing out in the bacterium Escherichia coli (E. coli), its ability to survive and reproduce is increased. These results are now ublished in the open-access journal PLoS Genetics on July 28th(*).

Usually, the acquisition of new genes, either through the insertion of pieces of DNA called plasmids or through mutations, comes at a cost to the bacteria, reflected in a reduction in its rate of cell division, for example. Francisco Dionsio, senior author of the paper, describes the process using the following analogy: "if you disassembled your computer and randomly changed connections and pieces, you wouldn't expect it to work better than before."

However, Francisco and his colleagues show that, when a mutation occurs in the chromosome of a bacterium that has already incorporated a resistance-carrying plasmid, the bacteria divide faster in 10% of the mutation-plasmid combinations tested. Similarly, bacteria that first acquire resistance to antibiotics through mutation of their chromosome and then gain further resistance by insertion of plasmids into their DNA show reproduction rate increases in 32% of combinations.

In 2009, the same research groups showed, for the first time, the importance of interactions between random genes in determining antibiotic resistance in bacteria. This latest study takes their initial findings a step further, by demonstrating that this is a general phenomenon, and thus may help to predict how a bacterial population will evolve after receiving a plasmid th
'/>"/>

Contact: Silvia Castro
sacastro@igc.gulbenkian.pt
351-214-464-537
Instituto Gulbenkian de Ciencia
Source:Eurekalert  

Page: 1 2

Related biology technology :

1. Gene against bacterial attack unravelled
2. Anacor Achieves Milestone from GSK for Boron-Based Systemic Antibacterial Product Candidate
3. DNA2.0 Introduces Freedom of Expression With a New Family of Bacterial Expression Vect:ors
4. Broad-Spectrum Antibacterial Activity is the Most Important Driver of Antibiotic Selection for Nosocomial Pneumonia In Europe
5. Advanced Life Sciences Receives FDA Guidance on Approval Pathway for Restanza in Community Acquired Bacterial Pneumonia and Biodefense Indications
6. Biologists discover an extra layer of protection for bacterial spores
7. Scientists ID bacterial genes that improve plant growth
8. First Self-Replicating, Synthetic Bacterial Cell Constructed by J. Craig Venter Institute Researchers
9. Synthetic Genomics Inc. Applauds the Venter Institutes Work in Creating the First Synthetic Bacterial Cell
10. Scientists boot up a bacterial cell with a synthetic genome
11. Biologists discover an extra layer of protection for bacterial spores
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Bacterial resistance to antibiotics: The more they resist, the more they divide
(Date:1/15/2014)... 2014 The Microcompetition with Foreign DNA ... disease. One of these latent viruses is the Epstein ... rheumatoid arthritis (RA). Rheumatoid arthritis (RA) is a chronic ... by the theory, a study found that RA patients ... (1). , What is Microcompetition? , Dr. Hanan ...
(Date:1/15/2014)... Sunnyvale, CA (PRWEB) January 15, 2014 ... of high throughput research solutions, today announced that ... companies, has received delivery of Freeslate’s CM ... form screening. , Lupin, headquartered in Mumbai, ... quality, affordable generic and branded formulations and Active ...
(Date:1/14/2014)... (PRWEB) January 14, 2014 Date: Friday, ... p.m. , Location: Warrington Country Club, 1360 Almshouse Road, ... Foundation, the only national nonprofit organization solely dedicated to ... quality of life for those affected worldwide, will host ... Warrington Country Club in Warrington, Pa. , Each ...
(Date:1/14/2014)... , Jan. 14, 2014  3D Communications, a leading provider ... major scientific, regulatory, business, and media events in ... , today announced its former associate Virginia Cox , ... office. Virginia Cox re-joins ... Commissioner for the Office of External Affairs at the U.S. ...
Breaking Biology Technology:Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 2Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 3Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 2Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 3Hepatitis B Foundation to Host Annual Crystal Ball Gala 2Former FDA Associate Commissioner Returns To 3D Communications 2
... Inc.,(Nasdaq: NVAX ) and the ... a preclinical study of a Respiratory Syncytial Virus ... rights from the, University of Massachusetts Medical School ... of Paramyxovirus vaccines incorporating,certain Virus-Like-Particles ("VLPs"). This ...
... announced as the recipient of a $750,000 investment by the Michigan ... ... Wire EON) December 9, 2008 -- Invest Michigan!, a program ... one of only two companies to receive capital in its first ...
... Dec. 9 First Coast Service Options (FCSO) has ... reimbursement solutions, to support a new Medicare contract awarded ... (CMS). , , Under ... Jan. 1, 2009 between health care providers and organizations ...
Cached Biology Technology:NOVAVAX and the University of Massachusetts Medical School Announce Preclinical Study Results for a Respiratory Syncytial Virus ('RSV') Vaccine Candidate 2NOVAVAX and the University of Massachusetts Medical School Announce Preclinical Study Results for a Respiratory Syncytial Virus ('RSV') Vaccine Candidate 3NOVAVAX and the University of Massachusetts Medical School Announce Preclinical Study Results for a Respiratory Syncytial Virus ('RSV') Vaccine Candidate 4 EcoSphere(R) Biolatex(TM) Secures Funding from Granholm and Invest Michigan! 2FCSO Selects Burgess as Exclusive Pricing Solution for New Medicare Contract 2
(Date:4/15/2014)... associate professor of mechanical engineering at Worcester ... the university,s Integrative Materials Design Center (iMdc), ... from leading engineering societies. , At its ... global association of more than 138,000 engineers ... aerospace, and commercial vehicle industries, presented Lados ...
(Date:4/15/2014)... who study the deadliest infectious diseases recognized the contributions ... at the University of Texas Medical Branch, with a ... on Filoviruses. The filoviruses include Ebola and Marburg viruses ... people infected. The current outbreak of Ebola virus raging ... so far. , "This award represents the culmination ...
(Date:4/15/2014)... Md. (April 15, 2014) The American Association ... award winners. All awards will be presented during ... Diego Marriott Hotel on Tuesday, April 29th at 7:30 ... (EB). , The 2014 award winners are: ... Jeffrey Laitman, PhD, of the Icahn School of Medicine ...
Breaking Biology News(10 mins):WPI's Diana Lados honored by SAE International and Minerals, Metals, and Materials Society 2WPI's Diana Lados honored by SAE International and Minerals, Metals, and Materials Society 3WPI's Diana Lados honored by SAE International and Minerals, Metals, and Materials Society 4WPI's Diana Lados honored by SAE International and Minerals, Metals, and Materials Society 5International research group recognizes UTMB experts 2International research group recognizes UTMB experts 3American Association of Anatomists 2014 award winners 2
... in the Archives of General Psychiatry, researchers at the ... the first time molecular circuitry associated with schizophrenia that ... "This is very exciting because until now the many ... connected in any way," says Akira Sawa, M.D., Ph.D., ...
... color, their knobby knees or their big feet to their children ... through those same genes. New research from the University of ... herpes virus 6 (HHV-6) to their children because it is integrated ... been shown to become part of the human DNA and then ...
... and other hoofed animals, new research suggests that, when ... study, published today in the open access journal ... wolves will reduce deer hunting activity and instead focus ... Victoria and the Raincoast Conservation Foundation, Canada, led a ...
Cached Biology News:Hopkins researchers piece together gene 'network' linked to schizophrenia 2Hopkins researchers piece together gene 'network' linked to schizophrenia 3Virus weaves itself into the DNA transferred from parents to babies 2Wolves would rather eat salmon 2
... Agencourt offers quick turnaround sequencing of ... copy and high copy plasmids. Agencourt's world-class, ... million Phred20 bases per day. The ... Sequencing service are 24 48 hour ...
Great for biotinylating DNA/RNA probes...
...
...
Biology Products: