Navigation Links
BRISTOL-MYERS SQUIBB SELECTS ISIS DRUG TARGETING PCSK9 AS DEVELOPMENT CANDIDATE FOR PREVENTION AND TREATMENT OF CARDIOVASCULAR DISEASE
Date:4/8/2008

Isis To Receive $2 Million Milestone Payment

CARLSBAD, Calif., April 8, 2008 /PRNewswire-FirstCall/ -- Isis Pharmaceuticals, Inc. (Nasdaq: ISIS) announced today that Bristol-Myers Squibb Company (NYSE: BMY) has selected a compound from the companies' collaboration as a development candidate. As a result, Isis will receive a $2 million milestone payment. The two companies have an ongoing collaboration to identify antisense drugs that target proprotein convertase subtilisin kexin 9 (PCSK9). The development candidate is an antisense inhibitor of PCSK9 that helps regulate the amount of cholesterol in the bloodstream.

The selection of this development candidate marks the achievement of the first milestone in this collaboration, which was announced on May 9, 2007. The compound was designed to selectively inhibit the production of PCSK9 and could offer a new and complementary mechanism to current lipid-lowering therapies for the prevention and treatment of cardiovascular disease.

"In less than a year, we have been able to identify and characterize a number of antisense drugs that inhibit PCSK9 in pre-clinical studies and out of those, identified an attractive development candidate. With the selection by Bristol-Myers Squibb of this development candidate, we have achieved our first milestone. The rapid progress we have made with our PCSK9 program is representative of the efficiency of our antisense technology to quickly move from target to drug," said Brett Monia, Ph.D., Vice President of Antis
'/>"/>

SOURCE Isis Pharmaceuticals, Inc.
Copyright©2008 PR Newswire.
All rights reserved

0

GOOD

Page: 1 2 3 4

Related biology technology :

1. Pfizer and Bristol-Myers Squibb Finalize Agreement for Worldwide Collaboration on Metabolic Disorders Program
2. Bristol-Myers Squibb to Acquire Adnexus Therapeutics
3. Aureus Pharma Announces Renewal and Expansion of Licensing Agreement With Bristol-Myers Squibb for its AurSCOPE Knowledge Databases
4. Bristol-Myers Squibb and Pierre Fabre Provide Update On Vinflunine Development Status
5. Bristol-Myers Squibb Company Outlines Strategy and Productivity Transformation Initiative During Update to Investment Community
6. EDS Awarded $715 Million Contract for Bristol-Myers Squibb Information Services
7. Exelixis Submits XL139 Diligence Report to Bristol-Myers Squibb
8. Bristol-Myers Squibb to Announce Results for the Fourth Quarter and Full Year of 2007 on January 31
9. Bristol-Myers Squibb Board Elects James M. Cornelius Chairman of the Board
10. Bristol-Myers Squibb Announces Dividend
11. Bristol-Myers Squibb Board Elects Jean-Marc Huet Senior Vice President and Chief Financial Officer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/3/2009)DALLAS, Dec. 3 ACCESS PHARMACEUTICALS, INC. (OTC Bulletin Board: ACCP), today provided an update on its European commercial launch of MuGard, an FDA approved treatment for oral mucositis, a deb
(Date:12/3/2009)WALTHAM, Mass., Dec. 3 Inverness Medical Innovations, Inc. (NYSE: IMA ), a global leader in enabling individuals to take charge of their health at home through the merger of rapid diagnostics and h
(Date:12/2/2009)MANILA, Philippines, Dec. 2 Spectrum Blue Steel is emerging as one of the fastest growing green energy companies on the planet. Through the efforts of True Green Energy Group and True Green Planet,s
(Date:12/2/2009)NEW YORK, Dec. 2 Nearly 600 medical research executives, scientists, policy makers, and funders today convened to explore novel development approaches and innovative funding strategies at the inaugur
Breaking Biology Technology:Access Pharmaceuticals Provides Update on MuGard Commercial Launch in Europe 2Access Pharmaceuticals Provides Update on MuGard Commercial Launch in Europe 3Access Pharmaceuticals Provides Update on MuGard Commercial Launch in Europe 4Spectrum Blue Steel partners with Famous Chemists for Procuring Profitable Applications from Garbage Using the Biosphere MKV and Electrostatic Precipitators 2Spectrum Blue Steel partners with Famous Chemists for Procuring Profitable Applications from Garbage Using the Biosphere MKV and Electrostatic Precipitators 3Medical Research Leaders Explore Novel Strategies to Expedite the Search for Cures 2
...A, Md., Jan. 8 Northwest Biotherapeutics, Inc. (O..."Company" or "NWBT") announced today settlement of...e Northwest Biotherapeutics, Inc. Securities Lit...ed to pay in settlement US$1 million, which is to ...nt must be approved by the Court. Additional deta...
... ALTOS, Calif., Jan. 8 InteKrin Therapeutics, Inc... Healthcare Conference at,9:00 a.m. Pacific Time o...tin,St. Francis in San Francisco, California. Inte... will present at the conference. , About InteK...erapeutics is a privately-held clinical stage biop...
...BRIDGE, Mass., Jan. 8 /PRNewswire/ -- The Nano S...unced that the Nanotech Conference & Expo 2009...own Convention Center, in Houston, Texas. Now in ...technology event is expected to attract a communit...y executives, who will gather to promote advanced ...
Other Biology Technology:Northwest Biotherapeutics Settles Class Action Complaint, and SEC Investigation Closed Without Action 2Northwest Biotherapeutics Settles Class Action Complaint, and SEC Investigation Closed Without Action 3InteKrin Therapeutics to Present at the 27th Annual JP Morgan Healthcare Conference on Tuesday, January 13 2NSTI Announces the 12th Annual Nanotech Conference & Expo 2009 May 3-7, at the George R. Brown Convention Center in Houston, Texas 2NSTI Announces the 12th Annual Nanotech Conference & Expo 2009 May 3-7, at the George R. Brown Convention Center in Houston, Texas 3NSTI Announces the 12th Annual Nanotech Conference & Expo 2009 May 3-7, at the George R. Brown Convention Center in Houston, Texas 4
(Date:12/4/2009)The body is a battle zone. Cells constantly compete with one another for space and dominance. Though the manner in which some cells win this competition is well known to be the survival of the fittest
(Date:12/4/2009)By measuring the total gene activity in organs relevant for coronary artery disease (CAD), scientists at the Swedish medical university Karolinska Institutet have identified a module of genes that is
(Date:12/4/2009)This release is available in German . , A new study of the Max Planck Institute for Biology of Ageing could help to understand the positive effect of dietary restriction on healthy ageing. Previou
Breaking Biology News(10 mins):Stem cells battle for space 2Scientists discover gene module underlying atherosclerosis development 2How nutrition affects healthy aging 2Tumor attacking virus strikes with one two punch 10941 1Tumor attacking virus strikes with one two punch 10941 2North Pole wolf emails locations to researchers 10938 1North Pole wolf emails locations to researchers 10938 2North Pole wolf emails locations to researchers 10938 3Exercise May Lead to a Smarter More Successful You 62353 1Exercise May Lead to a Smarter More Successful You 62353 2Exercise May Lead to a Smarter More Successful You 62353 3
... has found that one of the cell,s largest families... known to regulate the development of nerve cells,...ical chemicals and proteins for learning and memor...ar semaphores to this important nerve cell functio... published in advance at the journal,s website on ...
...ege of Forestry at Oregon State University have de...onize a large portion of the wood products industr...enefits. , The discovery has already resulted in t...ge of new products. But it was originally based on...stant professor, who was harvesting mussels one da...
...day announced the launch of MedScan?Text-to-Knowle... tool for automated extraction of biological facts...d other text sources. A demo version of MedScan is...everages hand-crafted dictionaries of protein and ...rn matching algorithms specifically developed for ...
Other Biology News:Structure-building cell signals also may influence learning and memory 2Structure-building cell signals also may influence learning and memory 3Nature provides inspiration for important new adhesive 2Nature provides inspiration for important new adhesive 3 Software Tool for Converting Scientific Text into a Database of Functional Relationships 2
...ia cardiac puncture from 3 to 4 week old rabbits (...ged and frozen at -70C. The complement is thawed, ...ored at -70C. DIRECT SALES FROM PEL-FREEZ BIOLOGIC... YOU CAN NOW BUY DIRECTLY FROM THE SOURCE! FORMER ...
Thermal Grayscale USB Printer for Imaging Systems; USB Connection from Alpha Innotech
GIBCO Newborn Calf Serum Heat-Inactivated from Invitrogen
Ready-To-Use IHC Bluing Reagent from Bethyl Laboratories
Biology Products: