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BRISTOL-MYERS SQUIBB SELECTS ISIS DRUG TARGETING PCSK9 AS DEVELOPMENT CANDIDATE FOR PREVENTION AND TREATMENT OF CARDIOVASCULAR DISEASE
Date:4/8/2008

Isis To Receive $2 Million Milestone Payment

CARLSBAD, Calif., April 8, 2008 /PRNewswire-FirstCall/ -- Isis Pharmaceuticals, Inc. (Nasdaq: ISIS) announced today that Bristol-Myers Squibb Company (NYSE: BMY) has selected a compound from the companies' collaboration as a development candidate. As a result, Isis will receive a $2 million milestone payment. The two companies have an ongoing collaboration to identify antisense drugs that target proprotein convertase subtilisin kexin 9 (PCSK9). The development candidate is an antisense inhibitor of PCSK9 that helps regulate the amount of cholesterol in the bloodstream.

The selection of this development candidate marks the achievement of the first milestone in this collaboration, which was announced on May 9, 2007. The compound was designed to selectively inhibit the production of PCSK9 and could offer a new and complementary mechanism to current lipid-lowering therapies for the prevention and treatment of cardiovascular disease.

"In less than a year, we have been able to identify and characterize a number of antisense drugs that inhibit PCSK9 in pre-clinical studies and out of those, identified an attractive development candidate. With the selection by Bristol-Myers Squibb of this development candidate, we have achieved our first milestone. The rapid progress we have made with our PCSK9 program is representative of the efficiency of our antisense technology to quickly move from target to drug," said Brett Monia, Ph.D., Vice President of Antis
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SOURCE Isis Pharmaceuticals, Inc.
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