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BG Medicine Signs Collaborative Research Agreement with the National Heart, Lung and Blood Institute (NHLBI), and Boston University
Date:3/12/2009

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The Framingham Heart Study (FHS) began in 1948 under the direction of NHLBI to study the development of cardiovascular disease over time. When FHS started it recruited an Original Cohort of 5,209 men and women between the ages of 30 and 62 from the town of Framingham, Massachusetts, who had not yet developed overt symptoms of cardiovascular disease or suffered a heart attack or stroke. Today, more than 9,000 participants spanning three generations are enrolled in the community-based study.

About BG Medicine

BG Medicine (www.bg-medicine.com) is developing novel diagnostic tests based on biomarkers that are intended to provide information to physicians that will improve patient treatment decisions. The company's diagnostic tests are designed to predict a patient's response to a drug therapy, determine the potential toxicity of therapeutic agents to patients who have or are likely to develop a specific disease, predict a patient's prognosis once a disease has been diagnosed and monitor a patient's disease progression or drug response.

The company's patented technology platform is the discovery engine that enables it to identify new biomarkers by integrating and automating the measurement, analysis, characterization and interpretation of proteins and small non-protein biological molecules, or metabolites, collected from bodily fluids.

BG Medicine initiated the HRP Initiative (www.HRPInitiative.com), the largest industry funded biomarker initiative that aims to develop new means of recognizing those at highest risk for heart attack or stroke. The HRP Initiative is supported and directed by Merck, AstraZeneca, Abbott, Takeda, and Philips. We have ongoing joint initiatives with major

pharmaceutical companies, other healthcare organizations including Humana and Philips and the U.S
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