Navigation Links
BERG Initiates Phase I/II Monotherapy Trial of BPM 31510-IV in Patients with Glioblastoma Multiforme (GBM)
Date:2/15/2017

BOSTON, Feb. 15, 2017 /PRNewswire/ -- BERG LLC, a biopharmaceutical company uncovering health solutions through a data-driven, biological research approach, today announced that it has initiated a Phase I/II monotherapy clinical trial for its drug candidate BPM 31510-IV for the potential treatment of glioblastoma multiforme. The compound was guided in development by BERG's unique AI-based Interrogative Biology® platform that combines patient biology and artificial intelligence-based analytics to better understand the differences between healthy and disease environments.

"Glioblastoma is one of the deadliest and most insidious forms of cancer and we are working to make a much-needed difference in the lives of patients with glioblastoma to improve survival, and quality of life," said Niven R. Narain, BERG Co-Founder, President and Chief Executive Officer of BERG. "The initiation of this Phase I/II trial marks the continued advancement of BPM 31510-IV, and further demonstrates BERG's Interrogative Biology® platform."

Currently, there are minimal treatment options for patients with GBM and with the five-year relative survival rate at only 5.1 percent new treatment strategies are urgently needed (National Brain Tumor Society). Standard of care treatment options are limited, often resulting in recurrence of the disease after multiple lines of therapy. As such, patients with GBM are in critical need of an effective and tolerable treatment option to increase rates of survival and quality of life.

The Phase I/II open-label, non-randomized clinical trial is designed to evaluate the safety and tolerability of BPM 31510-IV in subjects with glioblastoma multiforme that has recurred on a bevacizumab-containing regimen. Secondary outcome measures are to characterize the pharmacokinetics and pharmacodynamics of BPM31510-IV in subjects with glioblastoma multiforme that has recurred on a bevacizumab-containing regimen. The trial is initially being conducted at the Stanford University School of Medicine by principal investigators Dr. Seema Nagpal and Dr. Lawrence Recht.

BPM 31510-IV was previously demonstrated to be safe in patients in a Phase I clinical trial in solid tumors. Additionally, preclinical studies conducted by BERG, the Stanford University School of Medicine and the Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine suggest the therapeutic efficacy of BPM 31510-IV as single agent in GBM. These studies also demonstrate the possible beneficial effect of BPM 31510-IV in combination with temozolamide (TMZ), the existing standard of care for GBM. In pre-clinical models, pretreatment with BPM 31510-IV followed by TMZ showed reduced cancer cell proliferation when compared to monotherapy.

For more detail regarding this trial, please visit: https://clinicaltrials.gov/ct2/show/NCT03020602

About BPM 31510-IV

BPM 31510-IV has the potential to slow or stop cancer cell growth by reversing the compromised metabolism of cancer cells, which is hypothesized to be a fundamental driver of many different types of cancer.   BERG has also initiated a Phase II clinical trial for BPM 31510-IV in advanced pancreatic cancer in combination with a common cancer drug, among other ongoing and planned trials for BPM31510-IV in various oncological indications.

About Glioblastoma Multiforme

According to the National Brain Tumor Society, glioblastoma multiforme is the most common and deadliest of malignant primary brain tumors in adults. GBM accounts for 45% of all brain cancers, with nearly 11,000 men, women, and children diagnosed each year.

About BERG 
BERG is a clinical-stage company disrupting and redefining the approach to drug discovery, research and development through its Interrogative Biology® platform.  Its platform identifies therapies and biomarkers by applying algorithm and probability based artificial intelligence to analyze large numbers of patients' genotypic, phenotypic and other characteristics.  BERG believes this allows the company to better understand patients' disease profiles and consequently to reveal molecular signatures that guide and accelerate product candidate selection and development. By identifying biomarkers and patient characteristics that are unique to disease states, BERG is able to identify novel therapeutic product candidates and develop companion diagnostics to enhance specificity in its drug development process. BERG has leveraged its Interrogative Biology® platform to develop a robust pipeline of therapeutic product candidates and diagnostics in cancer, diabetes and neurology. 

For additional information, please visit www.BERGhealth.com.

To view the original version on PR Newswire, visit:http://www.prnewswire.com/news-releases/berg-initiates-phase-iii-monotherapy-trial-of-bpm-31510-iv-in-patients-with-glioblastoma-multiforme-gbm-300407595.html


'/>"/>
SOURCE BERG
Copyright©2017 PR Newswire.
All rights reserved


Related biology technology :

1. Sirnaomics Initiates a Clinical Phase IIa Study of Its Leading siRNA Therapeutic Candidate, STP705, for Treatment of Hypertrophic Scar
2. Protagonist Therapeutics Initiates Phase 2b Study of Oral Drug Candidate PTG-100 in Ulcerative Colitis
3. OncoQuest Initiates Commercial Scale Oregovomab Manufacturing Program for Treatment of Ovarian Cancer
4. Ability Pharmaceuticals Initiates Phase 2 Combination Trial with ABTL0812 as First-Line Therapy in Patients with Endometrial or Squamous Lung Cancer
5. Xencor Initiates Two Phase 2 Trials of XmAb5871 in IgG4-Related Disease and Systemic Lupus Erythematosus
6. AbbVie Initiates Enrollment in Phase 3 Clinical Program for Elagolix in Patients with Uterine Fibroids
7. Neurelis Initiates Pivotal Clinical Program for NRL-1 in the Treatment of Acute Repetitive Seizures
8. Profectus BioSciences Initiates Ebola Vaccine Phase 1 Clinical Trial
9. Pharnext Initiates PLEO-CMT, an International Pivotal Phase 3 Trial, in Charcot-Marie-Tooth disease type 1A
10. aTyr Pharma Initiates Phase 1b/2 Clinical Trial in Patients with Early Onset FSHD
11. Viking Therapeutics Initiates Phase 2 Trial of VK5211 in Patients Recovering From Hip Fracture
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/28/2017)... ... 28, 2017 , ... Ovation Fertility continues to ... presentation at the 33rd Annual Meeting of the European Society of Human ... world’s top thought leaders in reproductive medicine – are expected to attend the ...
(Date:6/28/2017)... ... 28, 2017 , ... Studies indicate that replacing damaged brain cells with those ... disease. But what has not been determined is the optimal stage during differentiation of ... , A new study coming out of Singapore, recently published in STEM CELLS Translational ...
(Date:6/27/2017)... (PRWEB) , ... June 27, 2017 , ... ... Certification Program (ESTCP), powder activated carbon (PAC)-based materials do not have negative short- ... community at a site contaminated with polychlorinated biphenyls (PCBs) located at the Puget ...
(Date:6/26/2017)... (PRWEB) , ... June 26, 2017 , ... Third Wave ... role of Sales Director, focused on leading new business development and ensuring quality customer ... of experience in the food ingredient industry in technical, marketing and sales roles. “Brett’s ...
Breaking Biology Technology:
(Date:3/30/2017)... ANGELES , March 30, 2017  On April ... Hack the Genome hackathon at Microsoft,s ... exciting two-day competition will focus on developing health and ... Hack the Genome is the ... been tremendous. The world,s largest companies in the genomics, ...
(Date:3/28/2017)... The report "Video Surveillance Market ... Storage Devices), Software (Video Analytics, VMS), and Service (VSaaS, ... to 2022", published by MarketsandMarkets, the market was valued ... to reach USD 75.64 Billion by 2022, at a ... year considered for the study is 2016 and the ...
(Date:3/23/2017)... India , March 23, 2017 The report "Gesture ... Touchless Biometric), Industry, and Geography - Global Forecast to 2022", published by MarketsandMarkets, ... at a CAGR of 29.63% between 2017 and 2022. ... ... ...
Breaking Biology News(10 mins):