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BASF Set To Commercialize pro-t-action(TM) Eliminating Caries Causing Bacteria From the Mouth
Date:4/1/2009

ity for only a minimum of 10 seconds to become active, pro-t-action(TM) is absolutely tasteless, odorless, pH-neutral and helps to maintain the healthy and beneficial microflora in the oral cavity.

"Working closely with OrganoBalance, we have been able to identify the L. paracasei strain that effectively and exclusively binds to the caries bacteria and in doing so improves elimination from the mouth," said Dr. Markus Pompejus, Senior Manager BASF Future Business GmbH. "The effectiveness of the active ingredients combined with BASF's ability to offer a product ready for incorporation into everyday oral care products, truly represents new and exciting possibilities in the way of significantly improving oral health."

Research on L. paracasei for the development of pro-t-action(TM) was conducted as a joint effort by OrganoBalance and BASF, in collaboration with the School of Dental Medicine at the University of Connecticut Health Center. The findings of the research, led by Dr. Jason M. Tanzer, University of Connecticut Health Center, and those of Dr. Christine Lang, OrganoBalance, will be presented at the International Association of Dental Research (IADR) annual conference held in Miami, FL, April 1-4.

Dr. Lang will provide details into the research conducted to identify the appropriate strain of Lactobacillus with the unique ability to bind specifically to Streptococcus mutans. "OrganoBalance's large proprietary strain collection and the unique screening capabilities were an important basis for this research," said Dr. Lang. "Application testing together with BASF revealed the potential for improved oral care."

Dr. Tanzer will present his work focusing on the blinded testing that was conducted to reveal a significant reduction, as much as 40 percent, in the level of colonization of Streptococcus mutans on the teeth, along with a substantial red
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