Navigation Links
Axelar AB Presents the New Anticancer Agent AXL1717 at The AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics in Boston, Massachusetts, USA
Date:11/13/2009

STOCKHOLM, November 13 /PRNewswire/ -- Axelar AB today announced that promising data from the ongoing Phase I/II clinical trial concerning their lead anticancer product AXL1717, an insulin-like growth factor-1 (IGF-1) receptor inhibitor, will be presented next week at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, Boston, Massachusetts, USA. The clinical trial is being conducted in Sweden on advanced-stage cancer patients with documented progressive solid tumors and no remaining treatment options. The first part of the trial has been successfully completed and showed that AXL1717 can be administered as a single-day BID treatment in very high doses without dose-limiting toxicity. The second part of the trial is ongoing and the patients are now being given AXL1717 daily for 7-28 days BID. Results so far show that AXL1717 can be taken in a multidose setting with good tolerability.

"We are very excited about our new clinical data on AXL1717 and pleased to be able to present them at this important scientific meeting" says Johan Harmenberg, CEO of Axelar AB. "Of particular interest is that even though the clinical trial so far was not designed to demonstrate efficacy, a number of patients show signs of tumor necrosis on PET (positron emission tomography). Targeting cancer cells with AXL1717 instead of conventional cytotoxic chemotherapy may become an effective and well-tolerated treatment alternative for cancer patients in the future".

About AXL1717, the IGF-1 Receptor and Cancer

AXL1717 is an orally administered small-molecule IGF-1 receptor inhibitor with no effect on the important and almost identical insulin receptor. Pre-clinical data on AXL1717 have shown an extraordinary anti-tumor efficacy in animal models, including complete regression of a wide range of human cancers.

The IGF-1 receptor is a validated target for anticancer treatment, the recept
'/>"/>

SOURCE Karolinska Development AB
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2

Related biology technology :

1. Successful Phase I/II Clinical Trial Results From Cancer Patients Treated With Anti-Cancer Drug From Axelar AB
2. Lexicon Presents Class of Compounds Modulating TPH1, the Target for its LX1031 Investigational Drug for Irritable Bowel Syndrome
3. Touching 418 Billion Lives, Hepatitis Still Presents Significant Threat to Global Health
4. Touching 418 Million Lives, Hepatitis Still Presents Significant Threat to Global Health
5. Nektar Presents Positive Results from Phase 1 Clinical Trial of NKTR-118 (oral PEG-naloxol) at American College of Clinical Pharmacology Meeting
6. Sangamo BioSciences Presents Data Demonstrating In Vivo Protection Against HIV Infection by CCR5-ZFN Therapeutic
7. Arpida Presents Preclinical and Clinical Data on Iclaprim at ICAAC
8. Arpida Presents Preclinical Data on AR-2474 at ICAAC
9. Resverlogix Presents Key Apo-Al/HDL Scientific Data at DALM
10. Arpida Presents Data on Iclaprim at Scientific Congress in Germany
11. BAI Retail Delivery Conference Softpro Presents Next Generation Signature Tablet
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/22/2014)... Minnesota electrical engineering researchers have developed a unique ... mechanical transportation of light. The discovery could have ... optical devices for computation and communication. , The ... computer engineering assistant professor Mo Li and his ... and will appear in the October issue of ...
(Date:9/22/2014)... NEW YORK , Sept. 22, 2014 ... US demand for specialty biocides is forecast to ... 2018. In volume terms, demand is projected to increase ... the same period. A strong rebound in construction expenditures ... and paint and coatings markets, while growth in consumer ...
(Date:9/22/2014)... -- Research and Markets has announced the ... Industry Report 2014" report to their offering. ... Report 2014 is a professional and in-depth study on ... with a focus on the Chinese situation. ... including definitions, classifications, applications and industry chain structure. The ...
(Date:9/22/2014)... 22, 2014 FierceBiotech today announced its ... biotechnology companies of 2014. FierceBiotech editors John Carroll ... this year’s winners. Those selected are identified as ... the industry. , "It's always a lot ... Fierce 15 companies," said Carroll. "This year in particular ...
Breaking Biology Technology:Engineers show light can play seesaw at the nanoscale 2US Biocides Market 2US Biocides Market 3Global and Chinese Microcrystalline Cellulose Industry Report 2014 2FierceBiotech Announces Annual “Fierce 15” Winners of 2014 2
... MedThink Communications, an,innovator in medical communications, ... two executives to serve the company,s growing,client ... Steven Palmisano, the new vice president ... team as it integrates creative thinking,and scientific ...
... April 30 Computer Sciences,Corporation (NYSE: CSC ... chief,medical officer and vice president of its North ... 10 in Modern Physician and Modern,Healthcare magazines, annual ... in April. Readers from both magazines nominated 7,300,physician ...
... 30 Neurobiological,Technologies, Inc. (NTI(R)) (Nasdaq: ... $2.0 million from Merz Pharmaceuticals GmbH (Merz) ... of Memantine for the treatment of,moderate-to-severe Alzheimer,s ... Under an exclusive marketing agreement, NTI currently ...
Cached Biology Technology:MedThink Hires Two Executives to Serve its Growing Pharmaceutical Client Base 2CSC's Dr. Robert M. Wah Makes Top 10 in 50 Most Powerful Physician Executives List 2
(Date:9/22/2014)... Ill. Antarctic fishes that manufacture their own ... Ocean also suffer an unfortunate side effect, researchers ... their bodies resist melting even when temperatures warm. ... Proceedings of the National Academy of Sciences ... an undesirable consequence of the evolution of antifreeze ...
(Date:9/22/2014)... 2014)The Brain & Behavior Research Foundation ... Young Investigator Grants valued at more than ... most promising young scientists. Recipients of the ... will seek to identify causes, improve treatments ... that affect one in four people, including ...
(Date:9/22/2014)... in homes, if they could locate people, places and ... and lasers, which have difficulty reliably recognizing things and ... complementary way robots can "sense" what is around them ... identification (UHF RFID) tags. Inexpensive self-adhesive tags can be ... a room for the correct tag,s signal, even when ...
Breaking Biology News(10 mins):Study: Antifreeze proteins in Antarctic fishes prevent freezingand melting 2Study: Antifreeze proteins in Antarctic fishes prevent freezingand melting 3Brain & Behavior Research Foundation awards 200 NARSAD Young Investigator grants 2New RFID technology helps robots find household objects 2New RFID technology helps robots find household objects 3
... but they are also infectious for human cells. However, ... Most importantly, these viruses have an astonishing property: They ... healthy tissue. Therefore, scientists in the teams of Jean ... Center (Deutsches Krebsforschungszentrum, DKFZ) have been investigating over the ...
... Ind. -- A field study of the relationship ... songbird, the dark-eyed junco, has defied some expectations ... Bloomington, the University of Virginia, Indiana University-Purdue University ... in the June issue of The American ...
... Washington, D.C.An unprecedented study of bald eagle diet, from ... will provide wildlife managers with unique information for reintroducing ... scientists, including researchers from the Carnegie Institution,s Geophysical Laboratory, ... 20,000 to 30,000 years ago to the 1840s and ...
Cached Biology News:Viruses against cancer 2Viruses against cancer 3Natural selection for moderate testosterone surprises scientists 2Natural selection for moderate testosterone surprises scientists 3Natural selection for moderate testosterone surprises scientists 4Bald eagle diet shift enhances conservation 2
... HVJ (hemagglutinating virus of Japan, also named ... tool for transfection of molecules by means ... for siRNA (RNAi), Protein, Oligo, cDNA, Antibodies, ... in vivo. GenomONE-Neo EX has a high ...
... Whole Genome ChIP-on-chip Microarray is specifically ... (S. cerevisiae) DNA binding proteins by ... DNA microarrays. This set delivers robust ... greater true binding events and fewer ...
... Faster speeds, highest precision, more ... flexible concept: this is the definition of ... few years nucleic acid research has been ... capabilities required of PCR Systems. To ...
... genomics-based research with S. aureus, Sigma-Genosys has developed ... primers to amplify all open reading frames (ORFs) ... are included to amplify ORFs that are unique ... S. aureus. The ORFmer set contains primers to ...
Biology Products: