ACI utilizes the increased activity of enzymes called proteases that occur in tumors and metastases. The fluorescent peptide changes color in the presence of pathological protease activity, thereby marking the cancerous tissue. When used in conjunction with a fluorescence imaging camera system during surgery, a color-coded image showing cancerous tissue is superimposed onto the normal surgical view, providing the surgeon a map of the cancer location.
In preclinical studies ACI has demonstrated high in vivo diagnostic sensitivity and specificity for detecting multiple rodent breast cancer metastases in lymph nodes and in ex vivo studies with human breast cancer patient tissue. By enabling real-time visualization of lymph node metastases and, potentially the primary tumor, in breast cancer, ACI has the potential to significantly improve surgical staging and decrease cancer-positive margins, the presence of which leads to reoperations.
About Avelas Biosciences
Avelas Biosciences is focused on developing fluorescent technologies that advance a new standard-of-care for cancer surgery. Its lead technology is the Avelas Cancer Illuminator™ (ACI), founded on technology from Nobel Prize winner Roger Tsien, Ph.D. The privately held company is funded by Avalon Ventures.
|SOURCE Avelas Biosciences|
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