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Attagene's Breakthrough Transcription Factor Profiling Technology to be Described in Nature Methods
Date:2/25/2008

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"A defining feature of FACTORIAL(TM) is that all reporter constructs have virtually identical reporter sequences and thus produce nearly identical messages," says Dr. Makarov. "These reporter messages are equally susceptible to broad variations in experimental and detection conditions, such as degradation, amplification, and thus their relative concentrations remain unaffected. From this homogeneity stems an amazing robustness and reproducibility of assessments."

Among many potential applications of FACTORIAL(TM), one of the most promising is drug evaluation and predictive toxicology. By observing alterations in transcription factors activities in response to drug candidates, one can immediately identify the involved pathways. By comparing signatures of evaluated drug candidates with databases of reference profiles, one can obtain invaluable information about drug candidate's mechanisms of action and potential side effects. In this regard, the FACTORIAL(TM) assay greatly synergizes with conventional system biology approaches, such as transcriptomics and proteomics. Akin to that, the FACTORIAL(TM) assay may prove invaluable for predicting toxic properties of environmental toxicants. This application has been validated as a part of the ToxCast program of the U.S. Environmental Protection Agency.

Currently, the prototypical FACTORIAL(TM) evaluates slightly more than 40 transcription factor families, but the system can be readily expanded by including additional reporters. Researchers believe that eventually they will be able to evaluate the entire complement of human transcription factors.

About Attagene

Attagene Inc. is biotechnological company founded in 2001 and located in the Research Triangle Park, North Carolina. Its mission is to accelerate drug discovery and development by providing innovative tools for examining signal transduction. Company's research team has scientists with academic and industrial background, with exp
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