| HOME >> BIOLOGY >> TECHNOLOGY |
oach.
"A defining feature of FACTORIAL(TM) is that all reporter constructs have virtually identical reporter sequences and thus produce nearly identical messages," says Dr. Makarov. "These reporter messages are equally susceptible to broad variations in experimental and detection conditions, such as degradation, amplification, and thus their relative concentrations remain unaffected. From this homogeneity stems an amazing robustness and reproducibility of assessments."
Among many potential applications of FACTORIAL(TM), one of the most promising is drug evaluation and predictive toxicology. By observing alterations in transcription factors activities in response to drug candidates, one can immediately identify the involved pathways. By comparing signatures of evaluated drug candidates with databases of reference profiles, one can obtain invaluable information about drug candidate's mechanisms of action and potential side effects. In this regard, the FACTORIAL(TM) assay greatly synergizes with conventional system biology approaches, such as transcriptomics and proteomics. Akin to that, the FACTORIAL(TM) assay may prove invaluable for predicting toxic properties of environmental toxicants. This application has been validated as a part of the ToxCast program of the U.S. Environmental Protection Agency.
Currently, the prototypical FACTORIAL(TM) evaluates slightly more than 40 transcription factor families, but the system can be readily expanded by including additional reporters. Researchers believe that eventually they will be able to evaluate the entire complement of human transcription factors.
About Attagene
Attagene Inc. is biotechnological company founded in 2001 and located
in the Research Triangle Park, North Carolina. Its mission is to accelerate
drug discovery and development by providing innovative tools for examining
signal transduction. Company's research team has scientists with academic
and industrial background, with exp
'/>"/>
| SOURCE Attagene Inc. Copyright©2008 PR Newswire. All rights reserved |
Related biology technology :
1. Cephalon Announces Positive Results from a Pivotal Study of FENTORA in Opioid-tolerant Patients with Non-cancer Breakthrough Pain
2. NeoMatrix Announces Additional Funding for Breakthrough Breast Cancer Screening Test
3. Kingfisher Healthcare Launches Breakthrough Product in Europe
4. New technique can be breakthrough for early cancer diagnosis
5. Breakthrough research identifies how cells from pigs may cure diabetes
6. Harmonex Introduces CliniCom(TM), a Breakthrough in Psychiatric Intake and Assessment Technology
7. Medical Breakthrough ... Doctor Discovers Penetrating Carrier That Eradicates Fungus
8. H&V Introduces HVision Technology Platform to Accelerate Development of Breakthrough Products
9. Discovery Institute Bioethicist Lauds Breakthrough in Stem Cells Research that Eliminates Need for Human Cloning
10. Stem Cell Breakthrough Could End Human Embryonic Experimentation
11. Panacea Pharmaceuticals Lung Cancer Diagnostic Test, LC Detect(SM), Named One of Time Magazines Ten Biggest Medical Breakthroughs of 2007
| Copyright © 2003-2012 Bio-Medicine. All rights reserved. ABOUT | CONTACT US | DISCLAIMER | PRIVACY POLICY | TERMS AND CONDITIONS |  |