Navigation Links
Attagene's Breakthrough Transcription Factor Profiling Technology to be Described in Nature Methods
Date:2/25/2008

oach.

"A defining feature of FACTORIAL(TM) is that all reporter constructs have virtually identical reporter sequences and thus produce nearly identical messages," says Dr. Makarov. "These reporter messages are equally susceptible to broad variations in experimental and detection conditions, such as degradation, amplification, and thus their relative concentrations remain unaffected. From this homogeneity stems an amazing robustness and reproducibility of assessments."

Among many potential applications of FACTORIAL(TM), one of the most promising is drug evaluation and predictive toxicology. By observing alterations in transcription factors activities in response to drug candidates, one can immediately identify the involved pathways. By comparing signatures of evaluated drug candidates with databases of reference profiles, one can obtain invaluable information about drug candidate's mechanisms of action and potential side effects. In this regard, the FACTORIAL(TM) assay greatly synergizes with conventional system biology approaches, such as transcriptomics and proteomics. Akin to that, the FACTORIAL(TM) assay may prove invaluable for predicting toxic properties of environmental toxicants. This application has been validated as a part of the ToxCast program of the U.S. Environmental Protection Agency.

Currently, the prototypical FACTORIAL(TM) evaluates slightly more than 40 transcription factor families, but the system can be readily expanded by including additional reporters. Researchers believe that eventually they will be able to evaluate the entire complement of human transcription factors.

About Attagene

Attagene Inc. is biotechnological company founded in 2001 and located in the Research Triangle Park, North Carolina. Its mission is to accelerate drug discovery and development by providing innovative tools for examining signal transduction. Company's research team has scientists with academic and industrial background, with exp
'/>"/>

SOURCE Attagene Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3

Related biology technology :

1. Cephalon Announces Positive Results from a Pivotal Study of FENTORA in Opioid-tolerant Patients with Non-cancer Breakthrough Pain
2. NeoMatrix Announces Additional Funding for Breakthrough Breast Cancer Screening Test
3. Kingfisher Healthcare Launches Breakthrough Product in Europe
4. New technique can be breakthrough for early cancer diagnosis
5. Breakthrough research identifies how cells from pigs may cure diabetes
6. Harmonex Introduces CliniCom(TM), a Breakthrough in Psychiatric Intake and Assessment Technology
7. Medical Breakthrough ... Doctor Discovers Penetrating Carrier That Eradicates Fungus
8. H&V Introduces HVision Technology Platform to Accelerate Development of Breakthrough Products
9. Discovery Institute Bioethicist Lauds Breakthrough in Stem Cells Research that Eliminates Need for Human Cloning
10. Stem Cell Breakthrough Could End Human Embryonic Experimentation
11. Panacea Pharmaceuticals Lung Cancer Diagnostic Test, LC Detect(SM), Named One of Time Magazines Ten Biggest Medical Breakthroughs of 2007
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/3/2015)... 2015 NASA astronaut Scott Kelly , who ... spend a year living and working on the International Space ... to 7 a.m. EDT Monday, March 9. Kelly ... completes the final weeks of his training. The interviews will ... Television highlighting his mission training and previous spaceflights. ...
(Date:3/3/2015)... and Markets ( http://www.researchandmarkets.com/research/rcv4lq/gene_therapy ) has announced ... - 2025" report to their offering. ... extensive study on the marketed and pipeline gene therapies. ... this field for over a decade but there are ... one approved in the EU). There are many promising ...
(Date:3/3/2015)... March 3, 2015 Adaptive Biotechnologies announced today ... joining its Board of Director as Chair of the ... Zillow Group, Chad oversees all finance, treasury and accounting ... company,s core finance, treasury and accounting functions, and led ... acquisitions. In 2013, he was named Puget Sound Business ...
(Date:3/3/2015)... 3, 2015  Regenicin, Inc. (OTC Bulletin Board: ... development of and commercialization of regenerative cell therapies to ... today that it has received the final payment to ... Inc. (OTC Bulletin Board: AMBS ). ... the final payments due to Regenicin in the amount ...
Breaking Biology Technology:NASA Astronaut Scott Kelly Available for Interviews before One-Year Space Station Mission 2Global Gene Therapy Market Report 2015-2025 - Extensive Study on the Marketed and Pipeline Gene Therapies 2Global Gene Therapy Market Report 2015-2025 - Extensive Study on the Marketed and Pipeline Gene Therapies 3Global Gene Therapy Market Report 2015-2025 - Extensive Study on the Marketed and Pipeline Gene Therapies 4Global Gene Therapy Market Report 2015-2025 - Extensive Study on the Marketed and Pipeline Gene Therapies 5Global Gene Therapy Market Report 2015-2025 - Extensive Study on the Marketed and Pipeline Gene Therapies 6Global Gene Therapy Market Report 2015-2025 - Extensive Study on the Marketed and Pipeline Gene Therapies 7Adaptive Biotechnologies adds Chad Cohen, Zillow Group CFO, to Board of Directors 2Regenicin (RGIN) Receives $2.3 Million in Final Payment from Amarantus 2Regenicin (RGIN) Receives $2.3 Million in Final Payment from Amarantus 3
... Rochelle, NY, February 8, 2011Successful intranasal delivery of ... Parkinson disease yielded significant improvement in motor function ... disease. These highly promising findings, reported in ... Mary Ann Liebert, Inc. highlight the potential for ...
... ST. LOUIS, Feb. 16, 2011 / PRNewswire/ ... announces the following executive leadership appointments intended to ... strategic plan. Frank Wicks, President Research, ... Research products, including those in Research Essentials, Research ...
... 16, 2011 Pneumococcus ( Streptococcus pneumoniae ) ... mortality in young children worldwide. While successful vaccines ... work against specific pneumococcal strains, with the risk ... Through a novel discovery approach, researchers at Children,s ...
Cached Biology Technology:Sigma-Aldrich Announces Organizational Changes 2Sigma-Aldrich Announces Organizational Changes 3New Pneumococcal Vaccine Approach Successful in Early Tests 2New Pneumococcal Vaccine Approach Successful in Early Tests 3New Pneumococcal Vaccine Approach Successful in Early Tests 4
(Date:1/22/2015)... Technology Showcase, Hall E -   EyeLock Inc. , ... it will showcase its EyeLock ID technology integrated in a ... Energy,s Oak Ridge National Laboratory (ORNL) at the ... identity authentication technology is being used to validate the driver ...
(Date:1/22/2015)... NXTD and NXTDW) a biometric authentication company focused on ... Wocket™ smart wallet at CES 2015 in Las Vegas ... the "11 Hot Products at CES" in a review published in Wired.com, ... Newseveryday.com and "The top 10 gadgets from CES 2015" by Danny ...
(Date:1/22/2015)... , January 22, 2015 , ... year  The European Patent Office to present a video ... British nominations to be featured: Christofer Toumazou and ... former finalists and winners of the Award   Starting ...
Breaking Biology News(10 mins):EyeLock Debuts First Iris Authentication Technology Embedded in 3D Printed Automobile 2EyeLock Debuts First Iris Authentication Technology Embedded in 3D Printed Automobile 3CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 2CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 3Ten Years of the European Inventor Award: A Retrospective Look at the Inventors and Ideas That Have Changed Our Lives 2Ten Years of the European Inventor Award: A Retrospective Look at the Inventors and Ideas That Have Changed Our Lives 3
... retrovirus exploits key proteins in its host cells to ... own survival and ability to spread, according to a ... Comprehensive Cancer Center Arthur G. James Cancer Hospital ... and Ohio State,s College of Veterinary Medicine. The ...
... Chinese Science Bulletin , Science China Life Sciences ... access journals and added to the SpringerOpen portfolio. All three ... a collection comprising more than 90 journals, with all their ... Chinese Science Bulletin and Science China Life Sciences ...
... RIDGE, Tenn, Feb. 22, 2011 -- A theoretical technique ... Laboratory is bringing supercomputer simulations and experimental results closer ... Jeremy Smith collaborated on devising a method -- dynamical ... and computer simulations to strengthen analyses of molecules in ...
Cached Biology News:Cancer-causing virus exploits key cell-survival proteins 2Selected journals in Springer's Chinese Library of Science join SpringerOpen 2'Fingerprints' match molecular simulations with reality 2
Anti-gp340 Monoclonal Antibody Description: 100 g Research Focus: cancer & cell proliferation Storage: -20C Shipping Temperature: 4C...
Mouse anti-HIV-Imn PND Class: Antibody Product Group: Bacterial and Viral Antigen...
... BRF2 Immunogen Synthetic peptide: QAARQAATSVPNPP, corresponding ... BRF2. Reactivity / Specificity Cross-reacts with ... Background Information BRF2 is one of the ... factor complex required for transcription of genes with ...
Kinase Buffer can be used to assay protein kinase activity...
Biology Products: