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Attagene's Breakthrough Transcription Factor Profiling Technology to be Described in Nature Methods
Date:2/25/2008

RESEARCH TRIANGLE PARK, N.C., Feb. 25 /PRNewswire/ -- Attagene Inc., a biotechnology company that develops innovative tools for signal transduction analysis, announced today that one of the Nature Research Journals highlights their flagmanship technology, the FACTORIAL(TM). In advance online publication on Nature Methods' website, Dr. Sergei Romanov with colleagues describes a novel and remarkably consistent method for simultaneously reporting on the activity of a large panel of transcription factors.

"The human genome has tens of thousands of genes, but only a fraction is expressed in a particular cell type at a given time. Understanding how gene expression is regulated is the Grail of the post-genomic era," says Dr. Sergei Makarov, Attagene's President and CEO, and the senior author. "A major hindrance is the lack of appropriate tools. We have found an entirely different way to characterize the functional status of cellular gene regulatory network."

Signals that modulate gene expression are relayed to genomic DNA by an intricate network of intracellular regulatory pathways. These pathways communicate with DNA by using transcription factors, proteins that bind particular sequences within target genes. An estimated few hundreds of transcription factor families hold the keys to regulation of the entire human genome; by assessing transcription factors activities one can capture the status of gene regulatory network. Therefore, Attagene's research team set to develop technology for assessment of activities of multiple transcription factors.

At the core of the proprietary technology, termed FACTORIAL(TM), is a set of reporter DNA constructs specially designed to evaluate particular transcription factors. When introduced into cell, the reporter constructs produce a spectrum of reporter RNA messages that mirror the activities of the evaluated transcription factors. These reporter messages are quantified by using an unconventional detection appr
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SOURCE Attagene Inc.
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