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Astute Medical, Inc. Advancing Next Generation Acute Kidney Injury Biomarkers
Date:2/6/2013

SAN DIEGO, Feb. 6, 2013 /PRNewswire/ -- Citing results of a clinical study published today in Critical Care, Astute Medical Chief Executive Officer Chris Hibberd said he is confident about the prospects for newly validated biomarkers of kidney damage used in the Company's NephroCheck® Test. The international, multi-center study validated the ability to predict acute kidney injury (AKI) using measurements of the two biomarkers, Insulin-like growth factor-binding protein 7 (IGFBP7) and tissue inhibitor of metalloproteinases-2 (TIMP-2) and demonstrated their superiority in risk assessment of AKI when compared with existing biomarkers.

The NephroCheck® Test is intended to aid in the risk assessment of AKI, a condition as prevalent and more deadly than heart attack. The test was launched in Europe in October 2012. It is not available for sale in the United States.

Much like a silent heart attack, AKI can strike without obvious symptoms. The condition is associated with high mortality rates, in part, because it often is not detected until it has reached the later stages when few management options exist.

"If unchecked, AKI can lead to loss of kidney function, often resulting in lower quality of life or even death," said Dr. John Kellum , a critical care physician at UPMC and principal investigator for the study. "Our data show that two urinary biomarkers of kidney damage can tell a doctor if a patient is at risk for AKI. In addition, these biomarkers provide additional information over clinical variables and add mechanistic insight into AKI, making them the most promising markers of AKI reported t
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SOURCE Astute Medical, Inc.
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