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AstraZeneca Submits sNDA for SEROQUEL XR(TM) for the Treatment of Major Depressive Disorder
Date:2/29/2008

(Global) as well as the FTSE4Good Index.

For more information visit http://www.astrazeneca-us.com.

The statements contain herein include forward-looking statements. Although we believe our expectations are based on reasonable assumptions, any forward-looking statements, by their very nature, involve risks and uncertainties and may be influenced by factors that could cause actual outcomes and results to be materially different from those predicted. The forward-looking statements reflect knowledge and information available at the date of the preparation of this press release and the Company undertakes no obligation to update these forward-looking statements. Important factors that could cause actual results to differ materially from those contained in forward-looking statements, certain of which are beyond our control, include, among other things, those risk factors identified in the Company's Annual Report/Form 20-F for 2006. Nothing contained herein should be construed as a profit forecast.

* The Montgomery-Asberg Depression Rating Scale (MADRS) measures the

severity of a number of depressive symptoms including sadness, tension,

sleep, appetite, energy, concentration, and suicidal ideation. The MADRS

score decreases as depressive symptoms improve.(5)

References

1. National Alliance on Mental Illness: Major Depression Fact Sheet. 2007. Available at: http://www.nami.org/Template.cfm?Section=By_Illness&Template=/TaggedPage/Ta gge dPageDisplay.cfm&TPLID=54&ContentID=26414 (Due to length of URL, please cut
and paste into browser). Accessed November 30, 2007.

2. Nemeroff, CB. Prevalence and Management of Treatment-Resistant

Depression. J Clin Psychiatry. 2007;68:17-25.

3. American Psychiatric Association. Prac
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