Navigation Links
Assembling cells into artificial 3-D microtissues, including a tiny gland
Date:3/5/2009

Berkeley -- As synthetic biologists cram more and more genes into microbes to make genetically engineered organisms produce ever more complex drugs and chemicals, two University of California chemists have gone a step further.

They have assembled different types of genetically engineered cells into synthetic microtissues that can perform functions such as secreting and responding to hormones, promising more complex biological capabilities than a single cell alone could produce.

"This is like another level of hierarchical complexity for synthetic biology," said coauthor Carolyn Bertozzi, UC Berkeley professor of chemistry and of molecular and cell biology and director of the Molecular Foundry at Lawrence Berkeley National Laboratory. "People used to think of the cell as the fundamental unit. But the truth is that there are collections of cells that can do things that no individual cell could ever be programmed to do. We are trying to achieve the properties of organs now, though not yet organisms."

While the synthetic tissues today comprise only a handful of cells, they could eventually be scaled up to make artificial organs that could help scientists understand the interactions among cells in the body and might some day substitute for human organs.

"We are really taking this into the third dimension now, which for me is particularly exciting," said first author Zev J. Gartner, a former UC Berkeley post-doctoral fellow who recently joined the UC San Francisco faculty as an assistant professor of pharmaceutical chemistry. "We are not simply linking cells together, we are linking them together in 3-D arrangements, which introduces a whole new level of cellular behavior which you would never see in 2-D environments."

Gartner and Bertozzi, the T.Z. and Irmgard Chu Distinguished Professor at UC Berkeley and a Howard Hughes Medical Institute investigator, report on their assembly of three-dimensional microtissues this week i
'/>"/>

Contact: Robert Sanders
rsanders@berkeley.edu
510-643-6998
University of California - Berkeley
Source:Eurekalert  

Page: 1 2 3

Related biology technology :

1. Self-assembling polymer arrays improve data storage potential
2. Novocell Announces Discovery Linking Key Cancer Cell Signaling Pathways With Proliferation and Self-Renewal of Human Embryonic Stem Cells
3. Reovirus Infection of Melanoma Cells Generates Anti-Tumour Immunity
4. Scientists synthesize memory in yeast cells
5. BioLife Solutions CryoStor(TM) Adopted by Tissue Regeneration Therapeutics for Preservation Protocol for New, Non-Embryonic Source of Stem Cells
6. Patent Office Rules in Neuralstems Favor in Dispute with StemCells, Inc.
7. NIH Announces Advanced Cell Technologys Single Cell Embryo Biopsy Technique as a Means to Derive Embryonic Stem Cells to be Considered for Federal Funding
8. Scientists synthesize memory in yeast cells
9. Breakthrough research identifies how cells from pigs may cure diabetes
10. Patent on Technology for the Delivery of Stem Cells to the Human Heart Issued to CellCyte Genetics Corp. of Washington
11. STEM CELLS Journal Names Co-Editors
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Assembling cells into artificial 3-D microtissues, including a tiny gland
(Date:8/21/2014)... August 21, 2014 On Wednesday of last ... to use Redox Signaling molecules, became available for purchase in ... , "The way that RENU 28 works is, if you ... down of the rate of cellular renewal within your body. ... increasing of that rate of cellular renewal. What RENU 28 ...
(Date:8/20/2014)... history lessons often have it that American Indians largely ... chicken pox, influenza and tuberculosis brought to the New ... vary, about 20 million people lived in the Americas ... them were killed by European diseases., But new research ... University and Johannes Krause of the University of Tubingen ...
(Date:8/20/2014)... California (PRWEB) August 20, 2014 ... develop and apply the most complete climate and ... and demanding climate change issues. , Eight national ... forces with the National Center for Atmospheric Research, ... the new effort. Other participating national laboratories include ...
(Date:8/20/2014)... 2014 The 6th Annual Arrowhead ... on October 29-30 in San Francisco, CA. This year’s ... government researchers and clinicians focused on addressing and solving ... In the twelve years since the sequencing of the ... introduced with pharmacogenetic information in the label and molecular ...
Breaking Biology Technology:RENU 28 Skin Care Now Available in Australia and New Zealand 2Unusual discovery leads to fascinating tuberculosis theory 2Unusual discovery leads to fascinating tuberculosis theory 3New Project Is the ACME of Addressing Climate Change 2New Project Is the ACME of Addressing Climate Change 36th Annual Personalized and Precision Medicine Conference Bringing Together Thought Leaders to Discuss Clinical Implementation, Dx Reimbursement, Big Data, and Sequencing 2
... COLOGNE, Germany and ... has opened its seventh laboratory worldwide in Electronics City in,the ... and systems. The world,leader in independent safety and quality testing ... new solar test centre, which in particular will,offer services to ...
... team based at the University of Pittsburgh has received ... of Defense to tackle some of the most significant ... that could solve problems too complex for all of ... the Universe to crack. The project was one of ...
... AVANIR Pharmaceuticals, Inc. (Nasdaq: ... Annual Canaccord Genuity Growth Conference on Tuesday, August 10th at ... at the InterContinental Hotel in Boston .  The Canaccord Genuity Growth ... and industry leaders.   , , ...
Cached Biology Technology:New Test Centre in India: TUV Rheinland Continues Worldwide Investment Programme for Solar Industry 2New Test Centre in India: TUV Rheinland Continues Worldwide Investment Programme for Solar Industry 3Pitt-led researchers to build foundation for quantum supercomputers with $7.5 million federal grant 2AVANIR to Present at the Canaccord Genuity Growth Conference 2
(Date:8/22/2014)... first comprehensive study of captive black rhino reproduction ... the success of breeding programmes. , Researchers from ... University of Liverpool carried out a six-year study ... rhino. , Dr Katie Edwards led the research ... of Liverpool. She says: "Although some black rhinoceros ...
(Date:8/22/2014)... 2015, American consumers will finally be able to purchase ... touted as zero-emissions vehicles, most of the cars will ... fuel that contributes to global warming. , Now scientists ... that uses an ordinary AAA battery to produce hydrogen ... current through two electrodes that split liquid water into ...
(Date:8/21/2014)... toxins in past decade, GTA still violates Canada,s ... while the Greater Toronto Area (GTA) has significantly ... smog, the city continues to violate the Canada-wide ... cause or aggravate health problems such as asthma, ... set of complex photochemical reactions involving volatile organic ...
Breaking Biology News(10 mins):Hormone analysis helps identify horny rhinos 2Stanford scientists develop a water splitter that runs on an ordinary AAA battery 2Stanford scientists develop a water splitter that runs on an ordinary AAA battery 3Despite a significant reduction in smog-producing toxins, the Greater Toronto Area still violates Canada's standards for ozone air pollution 2
... Fourth Biennial Review, 2012 -- a new congressionally mandated ... in the Comprehensive Everglades Restoration Plan (CERP), a multibillion-dollar, ... the ecosystem,s decline while meeting growing demands for clean ... evaluation of CERP, which was launched in 2000 by ...
... in cellular DNA can trigger tumorigenesis. Researchers from ... structure of a protein involved in the repair ... throws new light on the origins of neurodegenerative ... as radiation or environmental toxins can cause double-stranded ...
... Digicel Pacific Limited, a mobile network operator across the Pacific ... deploying biometric enabled payment systems into stores in New Zealand ... way to send money home to the Pacific. ... register just once and record their fingerprint as permanent identification ...
Cached Biology News:Digicel Launches World's First Biometric Identification System For International Money Transfers 2Digicel Launches World's First Biometric Identification System For International Money Transfers 3
Sequencing and primer design rolled into one. Just give us your clone and a reference sequence, and we'll do the rest. Single-strand or double-strand coverage. Guaranteed results....
... polyclonal antibody to human XAB2 (amino terminus) ... identified through its interaction with XPA. Immunoprecipitation ... of XAB2 interacts with the transcription-coupled repair-specific ... with RNA polymerase II. Microinjection experiments with ...
... provide custom microplate coating using advanced automated high throughput microplate ... formats. We can also accommodate virtually any lot size of ... , 8 and 12 ... 384 well microplate, ...
...
Biology Products: