Navigation Links
Artificial nanoparticles influence the heart rate
Date:8/1/2011

This release is available in German.

In light of the increasing demand for artificial nanoparticles in medicine and industry, it is important for manufacturers to understand just how these particles influence bodily functions and which mechanisms are at play questions to which there has been a dearth of knowledge. Studies on heart patients have shown for decades that particulate matter has a negative effect on the cardiovascular system. Yet, it remained unclear whether the nanoparticles do their damage directly or indirectly, for example through metabolic processes or inflammatory reactions. The reactions of the body are simply too complex.

Using a so-called Langendorff heart an isolated rodent heart flushed with a nutrient solution in place of blood scientists from the Helmholtz Zentrum Muenchen and the TU Muenchen were for the first time able to show that nanoparticles have a clearly measurable effect on the heart. When exposed to a series of commonly used artificial nanoparticles, the heart reacted to certain types of particles with an increased heart rate, cardiac arrhythmia and modified ECG values that are typical for heart disease. "We use the heart as a detector," explains Professor Reinhard Niener, Director of the Institute of Hydrochemistry at the TU Muenchen. "In this way we can test whether specific nanoparticles have an effect on the heart function. Such an option did not exist hitherto."

Scientists can also use this new model heart to shed light on the mechanism by which the nanoparticles influence the heart rate. In order to do this, they enhanced Langendorff's experimental setup to allow the nutrient solution to be fed back into the loop once it has flown through the heart. This allows the scientists to enrich substances released by the heart and understand the heart's reaction to the nanoparticles.

According to Stampfl and Niener, it is very likely that the neurotransmitter noradrenaline is responsible for the increased heart rate brought on by nanoparticles. Noradrenaline is released by nerve endings in the inner wall of the heart. It increases the heart rate and also plays an important role in the central nervous system a tip-off that nanoparticles might also have a damaging effect there.

Stampfl and his team used their heart model to test carbon black and titanium dioxide nanoparticles, as well as spark-generated carbon, which serves as a model for airborne pollutants stemming from diesel combustion. In addition, silicon dioxide, different Aerosil silicas used e.g. as thickening agents in cosmetics, and polystyrene were tested. Carbon black, spark-generated carbon, titanium dioxide and silicon dioxide led to an increase in the heart rate of up to 15 percent with altered ECG values that did not normalize, even after the nanoparticle exposure was ended. The Aerosil silicas and polystyrene did not show any effect on the heart function.

This new heart model may prove to be particularly useful in medical research. Here, artificial nanoparticles are increasingly being deployed as transportation vehicles. Their intrinsically large surfaces provide ideal docking grounds for active agents. The nanoparticles then transport the active agents to their destination in the human body, e.g. a tumor. Most of the initial prototypes of such "nano containers" are carbon or silicate based. So far, the effect of these substances on the human body is largely unknown. The new heart model could thus serve as a test organ to help select those particles types that do not affect the heart in a negative way.

Artificial nanoparticles are also used in many industrial products some of them since decades. Their small size and their large surfaces (compared to their volume) impart these particles with unique characteristics. The large surface area of titanium dioxide (TiO2), for example, leads to a large refractive index that makes the substance appear brilliant white. It is thus often used in white coating paints or as a UV blocker in sunscreens. So-called carbon black is also a widely used nanoparticle (mainly in car tires and plastics) with over 8 million tons produced annually. The small size of these nanoparticles (they measure only 14 nanometers across) makes them well suited as dyes, e.g. in printers and copying machines.

With their enhanced Langendorff heart, the researchers have now for the first time developed a measurement setup that can be used to analyze the effects of nanoparticles on a complete, intact organ without being influenced by the reactions of other organs. The heart is a particularly good test object. "It has its own impulse generator, the sinus node, enabling it to function outside the body for several hours," Andreas Stampfl, first author of the study, explains. "Additionally, changes in the heart function can be clearly recognized using the heart rate and ECG chart."

"We now have a model for a superior organ that can be used to test the influence of artificial nanoparticles," Niener explains further. "The next thing we want to do is to find out why some nanoparticles influence the heart function, while others do not influence the heart at all." Both manufacturing process and shape may play an important role. Hence, the scientists plan further studies to examine the surfaces of different types of nanoparticles and their interactions with the cells of the cardiac wall.


'/>"/>

Contact: Dr. Andreas Battenberg
battenberg@zv.tum.de
49-892-891-0510
Technische Universitaet Muenchen
Source:Eurekalert  

Related biology technology :

1. Brandeis labs artificial cilia spur new thinking in nanotechnology
2. Texas Childrens Hospital is First Pediatric Hospital in the Nation to Implant Artificial Heart
3. Harnessing the energy of the Sun: New technique improves artificial photosynthesis
4. Pitt-led researchers create super-small transistor, artificial atom powered by single electrons
5. Scientists create highly ordered artificial spin ice using nanotechnology
6. Engineers make artificial skin out of nanowires
7. Artificial Pancreas can Prevent the Development of Hypoglycemia
8. Scientists create artificial mini black hole
9. Cleveland researchers use natural and artificial sheaths to mend traumatic bone loss
10. First step to converting solar energy using artificial leaf
11. Scientists moving closer to artificial noses
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Artificial nanoparticles influence the heart rate
(Date:10/10/2017)... , ... October 10, 2017 , ... Dr. Bob Harman, ... his local San Diego Rotary Club. The event entitled “Stem Cells ... and had 300+ attendees. Dr. Harman, DVM, MPVM was joined by two human ...
(Date:10/10/2017)... ... 10, 2017 , ... USDM Life Sciences , the ... sciences and healthcare industries, announces a presentation by Subbu Viswanathan and Jennifer Jaye ... GxP Validation for Agile Cloud Platforms,” will present a revolutionary approach to achieving ...
(Date:10/9/2017)... ... October 09, 2017 , ... The award-winning American Farmer television ... quarter 2018. American Farmer airs Tuesdays at 8:30aET on RFD-TV. , With global ... the challenge of how to continue to feed a growing nation. At the same ...
(Date:10/9/2017)... (PRWEB) , ... October 09, ... ... published on October 5, 2017, in the medical journal, Epilepsia, Brain Sentinel’s ... the gold standard, video EEG, in detecting generalized tonic-clonic seizures (GTCS) using ...
Breaking Biology Technology:
(Date:6/23/2017)... and ITHACA, N.Y. , June ... Cornell University, a leader in dairy research, today announced ... designed to help reduce the chances that the global ... onset of this dairy project, Cornell University has become ... Sequencing the Food Supply Chain, a food safety initiative ...
(Date:5/16/2017)... DALLAS , May 16, 2017   ... for health organizations, and MD EMR Systems ... certified development partner for GE, have established a ... Patient Portal product and the GE Centricity™ products, ... Centricity EMR. These new integrations ...
(Date:4/18/2017)...  Socionext Inc., a global expert in SoC-based imaging and computing ... M820, which features the company,s hybrid codec technology. A demonstration utilizing ... Inc., will be showcased during the upcoming Medtec Japan at Tokyo ... Las Vegas Convention Center April 24-27. ... Click here for an image ...
Breaking Biology News(10 mins):